Investigation of Molecular Mechanisms Involved in T Lymphocyte Recruitment Across the Blood-Spinal Cord and Brain Barriers in Health and Disease

Blood-Spinal Cord and Brain Barriers in Health and Disease

Volumn , Issue , 2004, Pages 19-31

  Engelhardt, Britta ^a,b   Laschinger, Melanie ^a,b   Vajkoczy, Peter ^c  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84942872259     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012639011-7/50007-3     Document Type: Chapter

References (48)

1. Adamson P., Etienne S., Couraud P.O., Calder V., Greenwood J. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. J. Immunol. 1999, 162:2964-2973.
2. Alon R., Hammer D.A., Springer T.A. Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodyname flow. Nature 1995, 374:539-542.
3. Alon R., Kassner P.D., Carr M.W., Finger E.B., Hemler M.E., Springer T.A. The integrin VLA-4 support tethering and rolling in flow on VCAM-1. J. Cell Biol. 1995, 128:1243-1253.
4. Archelos J.J., Jung S., Maurer M., Schmied M., Lassmann H., Tamatani T., Miyasaka M., Toyka K.V., Hartung H.P. Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. Ann. Neurol. 1993, 34:145-154.
5. Barkalow F., Goodman M., Gerritsen M., TN M. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood 1996, 88:4585-4593.
6. Baron J.L., Madri J.A., Ruddle N.H., Hashim G., Janeway C.A. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 1993, 177:57-68.
7. Ben-Nun A., Wekerle H., Cohen I. The rapid isolation of clonable antigen-specific T cell lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 1981, 11:195.
8. Berlin C., Bargatze R.F., Campbell J.J., von Andrian U.H., Szabo M.C., Hasslen S.R., Nelson R.D., Berg E.L., Erlandsen S.L., Butcher E.C. α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995, 80:413-422.
9. Brocke S., Piercy C., Steinman L., Weissman I.L., Veromaa T. Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc. Natl. Acad. Sci. USA 1999, 96:6986.
10. Butcher E.C. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity. Cell 1991, 67:1033-1036.
11. Butcher E.C., Williams M., Youngman K., Rott L., Briskin M. Lymphocyte trafficking and regional immunity. Adv. Immunol. 1999, 72:209-253.
12. Campbell J.J., Qin S., Bacon K.B., Mackay C.R., Butcher E.C. Biology of chemokine and classical chemoattractant receptors. Differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells. J. Cell Biol. 1996, 134:255-266.
13. Cannella B., Cross A.H., Raine C.S. Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1993, 46:43-55.
14. Carlos T.M., Harlan J.M. Leukocyte-endothelial adhesion molecules. Blood 1994, 7:2068-2101.
15. Chen C., Mobley J.L., Dwir O., Shimron F., Grabovsky V., Lobb R.R., Shimizu Y., Alon R. High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on, VCAM-1 in shear flow. J. Immunol. 1999, 162:1084-1095.
16. Cross A.H., Cannella B., Brosnan C.F., Raine C.S. Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab. Invest. 1990, 63:162-170.
17. Cserr H.F., Knopf P.M. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view. Immunol. Today 1992, 13:507-512.
18. Engelhardt B., Vestweber D., Hallmann R., Schulz M. E-and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis. Blood 1997, 90:4459-4472.
19. Engelhardt B., Laschinger M., Schulz M., Samulowitz U., Vestweber D., Hoch G. The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. J. Clin. Invest. 1998, 102:2096-2105.
20. Engelhardt B., Martin-Simonet M.T., Rott L.S., Butcher E.C., Michie S.A. Adhesion molecule phenotype of T lymphocytes in inflamed CNS. J. Neuroimmunol. 1998, 84:92-104.
21. Gold R., Hartung H.P., Toyka K.V. Animal models for autoimmune demyelinating disorders of the nervous system. Mol. Med. Today 2000, 6:88-91.
22. Graesser D., Mahooti S., Madri J.A. Distinct roles for matrix metalloproteinase-2 and α4-integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2000, 109:121-131.
23. Hart D.N.J., Fabre J.W. Demonstration and characterization of la-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J. Exp. Med. 1981, 154:347-361.
24. Hickey W.F., Hsu B.L., Kimura H. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 1991, 28:254-260.
25. Johnston B., Issekutz T.B., Kubes P. Tha α4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 1996, 183:1995-2006.
26. Karpus J.W., Lukacs N.W., McRae B.L., Strieter R.M., Kunkel S.L., Miller S.D. An important role for the chemokine macrophage inflammatory protein-la in the pathogenesis of the T cell mediated autoimmune disease, experimental autoimmune encephalomyelitis. J. Immunol. 1995, 155:5003-5010.
27. Kennedy K.J., Strieter R.M., Kunkel S.L., Lukacs N.W., Karpus W.J. Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage, inflammatory protein-lalpha and monocyte chemotactic protein-1. J. Neuroimmunol. 1998, 92:98-108.
28. Kniesel U., Wolburg H. Tight junctions of the blood-brain barrier. Cell Mol. Neurobiol. 2000, 20:57-76.
29. Laschinger M., Engelhardt B. Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro. J. Neuroimmunol. 2000, 102:32-43.
30. Lassmann H. Chronic relapsing experimental allergic encephalomyelitis: Its value as an experimental model for multiple sclerosis. J. Neurol. 1983, 229:207-220.
31. Lichtman A.H., Ding H., Henault L., Vachino G., Camphausen R., Cumming D., Luscinskas F.W. CD45RA-RO+ (memory) but not CD45RA+RO-(naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow. J. Immunol. 1997, 158:3640-3650.
32. Lim Y.-C., Wakelin M.W., Haenault L., Goetz D.J., Yednock T., Cabanas C., Sanchez-Madrid F., Lichtman A.H., Luscinskas F.W. α4β1-integrin activation is necessary for high-efficiency T cell subset interactions with VCAM-1 under flow. Microcirc. 2000, 7:201-214.
33. Linington C., Bradl M., Lassmann H., Brunner C., Vass K. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am. J. Pathol. 1988, 130:443-454.
34. Martin R., McFarland H.F. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit. Rev. Clin. Lab. Sci. 1995, 32:121-182.
35. Martin R., McFarland H.F., McFarlin D.E. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 1992, 10:153-187.
36. Oppenheimer-Marks N., Davis L.S., Bogue D.T., Ramberg J., Lipsky P.E. Differential utilization of ICAM-1 and VCAM-11 during the adhesion and transendothelial migration of human T lymphocytes. J. Immunol. 1991, 147:2913-2921.
37. Reiss Y., Hoch G., Deutsch U., Engelhardt B. T cell interaction with ICAM-1-deficient endothelium in vitro: Essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells. Eur. J. Immunol. 1998, 28:3086-3099.
38. Ruegg C., Postigo A.A., Sikorski E.E., Butcher E.C., Pytela R., Erle D.J. Role of integrin alpha 4 beta 7/alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell, clustering. J. Cell Biol. 1992, 117:179-189.
39. Steffen B.J., Butcher E.C., Engelhardt B. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am. J. Pathol. 1994, 145(N1):189-201.
40. Uhl E., Pickelmann S., Rohrich F., Baethmann A., Schurer L. Influence of platelet-activating factor on cerebral microcirculation in rats: 2 Local application. Stroke 1999, 30:880-886.
41. Vajkoczy P., Laschinger M., Engelhardt B. α4-integrin-VCAM-1 binding mediates G-protein independent capture of encephalitogenic T cell blasts in CNS white matter microvessels. J. Clin. Invest. 2001, 8:557-565.
42. Vajkoczy P., Ullrich A., Menger M.D. Intravital fluorescence videomicroscopy to study tumor angiogenesis and microcirculation. Neoplasia (New York) 2000, 2:53-61.
43. von Andrian U.H., M'Rini C. In situ analysis of lymphocyte migration to lymph nodes. Cell Adh. Comm. 1998, 6:85-96.
44. Wekerle H., Engelhardt B., Risau W., Meyermann R. Passage of lymphocytes across the blood-brain barrier in health and disease. Pathophysiology of the Blood-Brain Barrier 1990, 439-445. Elsevier, New York. B.B. Johansson, C. Owman, H. Widner (Eds.).
45. Wekerle H., Kojima K., Lannes-Vieira J., Lassmann H., Linington C. Animal models. Ann. Neurol. 1994, 36:S47-S53.
46. Wekerle H., Linington C., Lassmann H., Meyermann R. Cellular immune reactivity within the CNS. TINS 1986, 9:271-277.
47. Welsh C.T., Rose J.W., Hill K.E., Townsend J.J. Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA-1α. J. Neuroimmunol. 1993, 43:161-168.
48. Willenborg D.O., Simmons R.D., Tamatani T., Miyasaka M. ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system. J. Neuroimmunol. 1993, 45:147-154.