Risk assessment of Fusarium mycotoxins in Lithuanian small cereal grains

Food Control

Volumn 22, Issue 6, 2011, Pages 970-976

  Mankevičienč, Audronč ^a   Butkutč, Bronislava ^a   Gaurilčikienč, Irena ^a   Dabkevičius, Zenonas ^a   Supronienč, Skaidrč ^a  

^a INSTITUTE OF AGRICULTURE   (Lithuania)

Author keywords

Co contamination; Fusarium mycotoxins; Small cereal grain

Indexed keywords

FUSARIUM; HORDEUM;

EID: 78751702752     PISSN: 09567135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodcont.2010.12.004     Document Type: Article

References (62)

1. Bennett J.W., Klich M. Mycotoxins. Clinical Microbiology Reviews 2003, 16(3):497-516.
2. 1) on growth of brewing yeasts. Journal of Applied Microbiology 2000, 88:388-403.
3. Choo T.M., Martin R.A., Ho K.M., Shen Q., Fedak G., Sevard M., et al. Fusarium head blight and deoxynivalenol accumulation of barley in Eastern Canada: cultivar response and correlation analysis. Plant Disease 2004, 88(8):837-844.
4. Council for Agricultural Science and Technology (CAST) Mycotoxins: Risks in plant, animal, and human system; Task Force report, No.139, Ames, Iowa, USA 2003.
5. Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicology Letters 2002, 127:19-28.
6. Diaz G.J., Squires E.J., Julian R.J., Boermans H.J. Individual and combined effects of T-2 toxin and DAS in laying hens. British Poultry Science 1994, 35(3):393-405.
7. Diekman M.A., Green M.L. Mycotoxins and reproduction in domestic livestock. Journal of Animal Sciences 1992, 70(5):1615-1627.
8. Eriksen, G. S. (2003). Metabolism and toxicity of Trichothecenes. Doctoral thesis, Uppsala, Sweden.
9. Eriksen G.S., Alexander J. Fusarium toxins in cereals - a risk assessment 1998, Nordic Council of Ministers, Copenhagen, Denmark, TemaNord report 502.
10. Eriksen G.S., Pettersson H. Toxicological evaluation of trichothecenes in animal feed. Animal Feed Science and Technology 2004, 114:205-239.
11. European Commission Recommendation Commission Recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Official Journal of the European Union 2006, L229:7-9.
12. European Commission Regulation Commission regulation (EC) No. 856/2005 of 6 June 2005: amending regulation (EC) No. 466/2001 as regards Fusarium toxins. Official Journal of the European Union 2005, L70:12-34.
13. European Commission Regulation Commission Regulation (EC) No. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuff. Official Journal of the European Union 2006, L364:5-24.
14. Fink-Gremmels J. Mycotoxins: their impact on human and animal health. Veterinary Quartely 1999, 21:115-120.
15. Fokunang C.N., Tembe-Fokunang E.A., Tomkins P., Barkwan S. Global impact of mycotoxins on human and animal health management. Outlook on Agriculture 2006, 35(4):247-253.
16. Gelderblom W.C., Marasas W.F., Vleggaar R., Thiel P.G., Cawood M.E. Fumonisins: isolation, chemical characterization and biological effects. Mycopathologia 1992, 117:11-16.
17. Glenn A.E. Mycotoxigenic Fusarium species in animal feed. Animal Feed Science and Technology 2007, 137:213-240.
18. González H.H., Moltó G.A., Pacin A., Resnik S.L., Zelaya M.J., Masana M., et al. Trichothecenes and mycoflora in wheat harvested in nine locations in Buenos Aires province, Argentina. Mycopathologia 2008, 165:105-114.
19. Goyarts T., Dänicke S., Valenta H., Ueberschär K.H. Carry-over of Fusarium toxins (deoxynivalenol and zearalenone) from naturally contaminated wheat to pigs. Food Additives and Contaminants 2007, 24:369-380.
20. Hilton A.J., Jenkinson P., Hollins T.W., Parry D.W. Relationship between cultivar height and severity of Fusarium ear blight in wheat. Plant Pathology 1999, 48:202-208.
21. Holt P.S., Buckley S., Norman J.O., Deloach J.R. Cytotoxic effect of T-2 mycotoxin on cells in culture as determined by a rapid colorimetric bioassay. Toxicon 1988, 26:549-558.
22. Huff W.E., Harvey R.B., Kubena L.F., Rottinghaus G.E. Toxic synergism between aflatoxin and T-2 toxin in broiler chickens. Poultry Science 1988, 67(10):1418-1423.
23. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. (1993) 56 http://monographs.iarc.fr/ENG/Monographs/vol56/mono56.pdf.
24. Jackson L.S., Bullerman L.B. Effect of processing on Fusarium mycotoxins. Advances in Experimental Medicine and Biology 1999, 459:243-261.
25. Krska R., Pettersson H., Josephs R.D., Lemmens M., MacDonald S., Welzig E. Zearalenone in maize: stability testing and matrix characterization of a certified reference material. Food Additives and Contaminants Part A 2003, 20:1141-1152.
26. Kubena L.F., Edrington T.S., Harvey R.B., Buckley S.A., Phillips T.D., Rottinghaus G.E., et al. Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and T-2 toxin or deoxynivalenol in broiler chicks. Poultry Science 1997, 76:1239-1247.
27. Kuciel-Lisieska G., Obremski K., Stelmachów J., Gajeogonekcka M., Zielonka Ł, Jakimiuk E., et al. Presence of zearalenone in blood plasma in women with neoplastic lesions in the mammary gland. Bulletin Veterinary Institute Pulawy 2008, 52:671-674.
28. Kutra J., Siukscius A., Urbsys A., Pileckas V., Nainiene R., Mankeviciene A. Effects of zearalenone and product Toxy-Nil Plus dry on physiological responses of boar semen. Medycyna Weterynaryjna 2006, 62(1):43-46.
29. Larsen J.C., Hunt J., Perin I., Ruckenbauer P. Workshop on trichothecenes with a focus on DON: summary report. Toxicology Letters 2004, 1-22.
30. 1 and moniliformin in broiler chicks. Avian Diseases 2003, 47(4):1368-1375.
31. Magan N., Aldred D. Post-harvest control strategies: minimizing mycotoxins in the food chain. International Journal of Food Microbiology 2007, 119:131-139.
32. Malekinejad H., Schoevers E.J., Daemen I.J.J.M., Zijlstra C., Colenbrander B., Fink-Gremmels J., et al. Exposure of oocytes to the Fusarium toxins zearalenone and deoxynivalenol causes aneuploidy and abnormal embryo development in pigs. Biology of Reproduction 2007, 77:840-847.
33. Mankevičienč A. The effects of mycotoxin zearalenone on reproductive performance of boars and measures for inactivation of zearalenone. LLU Raksti 2002, 7(302):48-58.
34. Mankevičienč A., Butkutč B., Dabkevičius Z., Supronienč S. Fusarium mycotoxins in Lithuanian cereals from the 2004-2005 harvests. Annals of Agricultural and Environmental Medicine 2007, 14:103-107.
35. Mankevičienč A., Dabkevičius Z., Supronienč S., Mačkinaitč R. Mikroskopiniuogonek grybuogonek plitimo ir mikotoksinuogonek kiekio {ogonek}ieminiuogonek kviečiuogonek grduose priklausomumas nuo juogonek nučmimo laiko. Zemdirbyste-Agriculture 2007, 94(3):162-175. (in Lithuanian).
36. Mankevičienč A., Supronienč S., Dabkevičius Z., Auškalnienč O. The Incidence of Fusarium fungi and mycotoxins in wheat grain as affected by growth Regulators. Zemdirbyste-Agriculture 2008, 95(3):251-258.
37. Maragos C., Bumsan M., Sugita-Konishi Y. Production and characterization of a monoclonal antibody that cross-reacts with the mycotoxins nivalenol and 4-deoxynivalenol. Food Additives and Contaminants 2006, 23:816-825.
38. Milanez T.V., Valente-Soares L.M., Baptista G.G. Occurrence of trichothecene mycotoxins in Brazilian corn-based food products. Food Control 2006, 17(4):293-298.
39. Minervini F., Dell'Aquila M.E. Zearalenone and reproductive function in farm animals. International Journal of Molecular Sciences 2008, 9:2570-2584.
40. Moss M.O. Mycotoxin review - 2 Fusarium. Mycologist 2002, 16:158-161.
41. Omurtag G.Z., Yazicioglu D. Occurrence of T-2 toxin in processed cereals and pulses in Turkey determined by HPLC and TLC. Food Additives and Contaminants 2001, 18:844-849.
42. Omurtag G.Z., Yazicioglu D., Beyoglu D., Tozan A., Atak G. A review on fumonisin and trichothecene mycotoxins in foods consumed in Turkey. ARI, ITU-Bulletin 2006, 54:39-45.
43. Osweiler G.D. Diagnosis of mycotoxicoses. Occurrence and clinical manifestations of trichothecene toxicoses and zearalenone toxicoses 1986, 31-42. National Animal Disease Center, Ames, Iowa, USA. J.L. Richard, J.R. Thurston (Eds.).
44. Pacin A., Reale C., Mirengui H., Orellana L., Boente G. Subclinic effect of the administration of T-2 toxin and nivalenol in mice. Mycotoxin Research 1994, 10:34-46.
45. Paterson R.R.M., Lima N. How will climate change affect mycotoxins in food?. Food Research International 2009, 10.1016/j.foodres. 2009.07.10.
46. Paterson R.R.M., Lima N. Toxicology of mycotoxins. Molecular. Clinical and Environmental Toxicology 2010, 2:31-63.
47. Pestka J.J., Smolinski A.T. Deoxynivalenol: toxicology and potential effects on humans. Journal of Environmental Science and Health, Part B 2005, 8:39-69.
48. Placinta C.M., D'Mello J.P.F., Macdonald A.M.C. A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins. Animal Feed Science and Technology 1999, 78:21-37.
49. Rabie C.J., Sydenham E.W., Thiel P.G., Lübben A., Marasas W.F.O. T-2 toxin production by Fusarium acuminatum isolated from oats and barley. Applied and Environmental Microbiology 1986, 52:594-596.
50. Rodrigues I. Biomin mycotoxins survey program 2008 2009, International Food Safety & Quality Network, Available at, Accessed 23.06.10. http://www.ifsqn.com/articles_detail.php%3Fnewsdesk_id%3D656&osCsid%3D2009.
51. Rotter B.A., Prelusky D.B., Pestka J.J. Invited review: toxicology of deoxynivalenol (vomitoxin). Journal of Toxicology and Environmental Health Part A 1996, 48:1-34.
52. Scientific Committee on Food (SCF) Opinion of the scientific committee on food on fusarium toxins. Part 2: Zearalenone (ZEA) 2000, Available at, Accessed 22.06.00. http://www.europa.eu.int/comm/food/fs/sc/scf/out65_en.pdf.
53. Severino L., Luongo D., Bergamo P., Lucisano A., Rossi M. Mycotoxins nivalenol and deoxynivalenol differentially modulate cytokine mRNA expression in Jurkat T cells. Cytokine 2006, 36:75-82.
54. Speijers G.J.A., Speijers M.H.M. Combined toxic effects of mycotoxins. Toxicology Letters 2004, 153(1):91-98.
55. Stadnic A., Borzeogonekcki A. Influence of the zearalenone on the activity of chosen liver enzymes in a rat. Annals of Agricultural and Environmental Medicine 2009, 16:31-35.
56. Supronienč, S. (2009). Factors influencing the occurrence of Fusarium fungi and mycotoxin accumulation in cereal grain. Doctoral Thesis. Akademija, Lithuanian.
57. Swamy H.V., Smith T.K., MacDonald E.J., Boermans H.J., Squires E.J. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent. Journal of Animal Sciences 2002, 80:3257-3267.
58. Tajima O., Schoen E.D., Feron V.J., Groten J.P. Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions. Food and Chemical Toxicology 2002, 40(5):685-695.
59. Tarakanovas P., Raudonius S. Statistical analysis of agronomical research data using software ANOVA, STAT, SPLIT-PLOT from packet SELEKCIJA and IRRISTAT. Akademija 2003, (in Lithuanian).
60. Wijnands L.M., van Leusden F.M. An overview of adverse health effects caused by mycotoxins and biossays for their detection 2000, RIVM report 257852 004, Bilthoven.
61. Xu X. Effects environmental conditions on the development of Fusarium ear blight. European Journal of Plant Pathology 2003, 109:683-689.
62. Yazar S., Omurtag G.Z. Fumonizins, trichothecenes and zearalenone in cereals. International Journal of Molecular Sciences 2008, 9:2062-2090.