Individual and Combined Effects of Fumonisin B1 Present in Fusarium moniliforme Culture Material and T-2 Toxin or Deoxynivalenol in Broiler Chicks

Poultry Science

Volumn 76, Issue 9, 1997, Pages 1239-1247

  Kubena, L F ^a   Edrington, T S ^a   Harvey, R B ^a   Buckley, S A ^a   Phillips, T D ^b   Rottinghaus, G E ^c   Casper, H H ^d  

^a SOUTHERN PLAINS AGRICULTURAL RESEARCH CENTER   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Chicken; Deoxynivalenol; Fumonisin; T 2 toxin; Toxicity

Indexed keywords

FUSARIUM; GALLUS GALLUS; GIBBERELLA FUJIKUROI; TRITICUM AESTIVUM;

CALCIUM; CARBOXYLIC ACID; CARCINOGEN; CHOLESTEROL; FUMONISIN; FUMONISIN B1; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; SERUM ALBUMIN; T 2 TOXIN; TRICHOTHECENE DERIVATIVE; VOMITOXIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; AVIAN STOMACH; BLOOD; BODY WEIGHT; CHEMISTRY; CHICKEN; COMPARATIVE STUDY; DIET; DRUG COMBINATION; DRUG EFFECT; FUSARIUM; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; ISOLATION AND PURIFICATION; KIDNEY; LIVER; MALE; METABOLISM; MICROBIOLOGY; ORGAN SIZE; PHYSIOLOGY; UREA NITROGEN BLOOD LEVEL; WEIGHT GAIN; WHEAT;

ANIMALS; BLOOD UREA NITROGEN; BODY WEIGHT; CALCIUM; CARBOXYLIC ACIDS; CARCINOGENS, ENVIRONMENTAL; CHICKENS; CHOLESTEROL; DIET; DRUG COMBINATIONS; FUMONISINS; FUSARIUM; GAMMA-GLUTAMYLTRANSFERASE; GIZZARD; KIDNEY; L-LACTATE DEHYDROGENASE; LIVER; MALE; ORGAN SIZE; SERUM ALBUMIN; T-2 TOXIN; TRICHOTHECENES; TRITICUM; WEIGHT GAIN;

EID: 0031227822     PISSN: 00325791     EISSN: None     Source Type: Journal    
DOI: 10.1093/ps/76.9.1239     Document Type: Article

References (73)

1. Bamburg, J. R., F. M. Strong, and E. B. Smalley, 1970. Toxins from moldy feed cereals. J. Agric. Food Chem. 17:443-450.
2. Brown, T. P., G. E. Rottinghaus, and M. E. Williams, 1992. Fumonisin mycotoxicoses in broilers: Performance and pathology. Avian Dis. 36:450-454.
3. Chi, M. S., and C. J. Mirocha, 1978. Necrotic oral lesions in chickens fed diacetoxyscirpenol, T-2 toxin and crocotin. Poultry Sci. 57:807-808.
4. Chi, M. S., C. J. Mirocha, H. J. Kurtz, G. Weaver, F. Bates, and W. Shimoda, 1977. Subacute toxicity of T-2 toxin in broiler chicks. Poultry Sci. 56:306-313.
5. Clement, B. A., and T. D. Phillips, 1985. Advances in the detection and determination of mycotoxins via capillary GC/quadrupole mass spectrometry. Toxicologist 5(1):232. (Abstr.)
6. Colvin, B. M., A. J. Cooley, and R. W. Beaver, 1993. Fumonisin toxicosis in swine: Clinical and pathologic findings. J. Vet. Diagn. Invest. 5:232-241.
7. Côté, L. M., J. D. Reynolds, R. F. Vesonder, W. B. Buck, S. P. Swanson, R. T. Coffey, and D. C. Brown, 1984. Survey of vomitoxin-contaminated feed grains in midwestern United States, and associated health problems in swine. J. Am. Vet. Med. Assoc. 184:189-192.
8. Doerr, J. A., P. B. Hamilton, and H. R. Burmeister, 1981. T-2 toxicosis and blood coagulation in young chickens. Toxicol. Appl. Pharmacol. 60:157-162.
9. Forsyth, D. M., L. Yoshizawa, N. Morooka, and J. Tuite, 1977. Emetic and refusal activity of deoxynivalenol in swine. Appl. Environ. Microbiol. 34:547-552.
10. 1 in rats. Carcinogenesis 12:1247-1251.
11. Gelderblom, W.C.A., W.F.O. Marasas, R. Vleggaar, P. G. Thiel, and M. E. Cawood, 1992. Fumonisins: Isolation, chemical characterization and biological effects. Mycopathologia 117:11-16.
12. Hagler, W. M., Jr., K. Tyczkowska, and P. B. Hamilton, 1984. Simultaneous occurrence of deoxynivalenol, zearalenone, and aflatoxin in 1982 scabby wheat from the Midwestern United States. Appl. Environ. Microbiol. 47:151-154.
13. Hamilton, R.M.G., B. K. Thompson, H. L. Trenholm, P. S. Fiser, and R. Greenhalgh. 1985a. Effects of feeding White Leghorn hens diets that contain deoxynivalenol (vomitoxin)-contaminated wheat. Poultry Sci. 64: 1840-1852.
14. Hamilton, R.M.G., H. L. Trenholm, and B. K. Thompson, 1983. Effects of feeding chicks and laying hens diets that contain vomitoxin (deoxynivalenol) contaminated wheat. Proc. Annu. Nutr. Conf. Feed Manuf. 19:48-55.
15. Hamilton, R.M.G., H. L. Trenholm, B. K. Thompson, and R. Greenhalgh, 1985b. The tolerance of White Leghorn and broiler chicks, and turkey poults to diets that contain deoxynivalenol (vomitoxin)-contaminated wheat. Poultry Sci. 64:273-286.
16. 1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest. 2:217-221.
17. Hoerr, F. J., W. W. Carlton, and B. Yagen, 1981a. The toxicity of T-2 toxin and diacetoxyscirpenol in combination for broiler chickens. Food Cosmetics Toxicol. 19:185-188.
18. Hoerr, F. J., W. W. Carlton, and B. Yagen, 1981b. Mycotoxicosis caused by single doses of T-2 toxin or diacetoxyscirpenol in broiler chickens. Vet. Pathol. 18:652-664.
19. Hoerr, F. J., W. W. Carlton, B. Yagen, and A. Z. Joffe, 1982a. Mycotoxicosis produced in broiler chickens by multiple doses of either T-2 toxin or diacetoxyscirpenol. Avian Pathol. 11:369-383.
20. Hoerr, F. J., W. W. Carlton, B. Yagen, and A. Z. Joffe, 1982b. Mycotoxicosis caused by either T-2 toxin or diacetoxyscirpenol in the diet of broiler chickens. Fundam. Appl. Toxicol. 2:121-124.
21. Huff, W. E., and J. A. Doerr, 1981. Synergism between aflatoxin and ochratoxin A in broiler chickens. Poultry Sci. 60: 550-555.
22. Huff, W. E., J. A. Doerr, C. J. Wabeck, G. W. Chaloupka, J. D. May, and J. W. Merkley, 1983. Individual and combined effects of aflatoxin and ochratoxin on bruising in broiler chickens. Poultry Sci. 62:1764-1771.
23. Huff, W. E., R. B. Harvey, L. F. Kubena, and G. E. Rottinghaus, 1988a. Toxic synergism between aflatoxin and T-2 toxin in broiler chickens. Poultry Sci. 67:1418-1423.
24. Huff, W. E., L. F. Kubena, R. B. Harvey, and J. A. Doerr, 1988b. Mycotoxin interactions in poultry and swine. J. Anim. Sci. 66:2351-2355.
25. Huff, W. E., L. F. Kubena, R. B. Harvey, W. M. Hagler, Jr., S. P. Swanson, R. D. Phillips, and C. R. Creger, 1986. Individual and combined effects of aflatoxin and deoxynivalenol (DON, vomitoxin) in broiler chickens. Poultry Sci. 65: 1291-1298.
26. Hulan, H. W., and F. G. Proudfoot, 1982. Effects of feeding vomitoxin-contaminated wheat on the performance of broiler chickens. Poultry Sci. 61:1653-1659.
27. 1, and moniliformin. Mycopathologia 123:171-184.
28. 1 and moniliformin. J. Vet. Diagn. Invest. 7:520-526.
29. 1. Onderstepoort J. Vet. Res. 57: 269-275.
30. Klaassen, C. D., and D. L. Eaton, 1991. Principles of toxicology. Pages 12-49 in: Toxicology, The Basic Science of Poisons. M. O. Amdur, J. Doull, and C. D. Klaassen, ed. Pergamon Press, Inc., Maxwell House, Fairview Park, Elmsford, NY.
31. 1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults. Poultry Sci. 75:256-265.
32. 1 present in Fusarium moniliforme culture material and T-2 toxin in turkey poults. Poultry Sci. 74:306-313.
33. 1 present in Fusarium moniliforme culture material and aflatoxin singly and in combination to turkey poults. Poultry Sci. 74:1295-1303.
34. Kubena, L. F., and R. B. Harvey, 1988. Research note: Response of growing Leghorn chicks to deoxynivalenol-contaminated wheat. Poultry Sci. 67:1778-1780.
35. Kubena, L. F., R. B. Harvey, T. S. Edrington, and G. E. Rottinghaus, 1994a. Influence of ochratoxin A and diacetoxyscirpenol singly and in combination on broiler chickens. Poultry Sci. 73:408-415.
36. Kubena, L. F., R. B. Harvey, W. E. Huff, D. E. Corrier, T. D. Phillips, and G. E. Rottinghaus, 1989a. Influence of ochratoxin A and T-2 toxin singly and in combination on broiler chickens. Poultry Sci. 68:867-872.
37. Kubena, L. F., R. B. Harvey, W. E. Huff, D. E. Corrier, T. D. Phillips, and G. E. Rottinghaus, 1990. Efficacy of a hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and T-2 toxin. Poultry Sci. 69: 1078-1086.
38. Kubena, L. R., R. B. Harvey, W. E. Huff, M. H. Elissalde, A. G. Yersin, T. D. Phillips, and G. E. Rottinghaus, 1993. Efficacy of a hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and diacetoxyscirpenol. Poultry Sci. 72:51-59.
39. Kubena, L. F., R. B. Harvey, R. D. Phillips, G. M. Holman, and C. R. Creger, 1987. Effects of feeding mature white Leghorn hens diets that contain deoxynivalenol (DON, vomitoxin). Poultry Sci. 66:55-58.
40. Kubena, L. F., W. E. Huff, R. B. Harvey, D. E. Corrier, T. D. Phillips, and C. R. Creger, 1988. Influence of ochratoxin A and deoxynivalenol on growing broiler chicks. Poultry Sci. 67:253-260.
41. Kubena, L. F., W. E. Huff, R. B. Harvey, T. D. Phillips, and G. E. Rottinghaus, 1989b. Individual and combined toxicity of deoxynivalenol and T-2 toxin in broiler chicks. Poultry Sci. 68:622-626.
42. Kubena, L. F., E. E. Smith, A. Gentles, R. B. Harvey, T. E. Edrington, T. D. Phillips, and G. E. Rottinghaus, 1994b. Individual and combined toxicity of T-2 toxin and cyclopiazonic acid in broiler chicks. Poultry Sci. 73: 1390-1397.
43. Kubena, L. F., S. P. Swanson, R. B. Harvey, O. J. Fletcher, L. D. Rowe, and T. D. Phillips, 1985. Effects of feeding deoxynivalenol (vomitoxin)-contaminated wheat to growing chicks. Poultry Sci. 64:1649-1655.
44. 1 and moniliformin, supplied by Fusarium moniliforme and Fusarium fujikuroi culture material, in the young broiler chick. Poultry Sci. 73(Suppl. 1):99. (Abstr.)
45. Ledoux, D. R., T. P. Brown, T. S. Weibking, and G. E. Rottinghaus, 1992. Fumonisin toxicity in broiler chicks. J. Vet. Diagn. Invest. 4:330-333.
46. Lun, A. K., L. G. Young, E. T. Moran, Jr., D. B. Hunter, and J. P. Rodriquez, 1986. Effects of feeding hens a high level of vomitoxin-contaminated corn on performance and tissue residues. Poultry Sci. 65:1095-1099.
47. 1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res. 55:197-203.
48. Mirocha, C. J., B. Schauerhamr, C. M. Christensen, and T. Kommendahl, 1979. Zearalenone, deoxynivalenol, and T-2 toxin associated with stalk rot in corn. Appl. Environ. Microbiol. 38:557-558.
49. Moran, E. T., Jr., P. R. Ferket, D. B. Hunter, and L. R. Young, 1983. Effect of vomitoxin-contaminated corn on poultry production. Pages 61-65 in: Proc. Maryland Nutr. Conf., University of Maryland, College Park, MD.
50. Moran, E. T., Jr., B. Hunter, P. Ferket, L. G. Young, and L. G. McGirr, 1982. High tolerance of broilers to vomitoxin from corn infected with Fusarium graminearum. Poultry Sci. 61: 1828-1831.
51. National Research Council, 1994. Nutrient Requirements of Poultry. 9th rev. ed. National Academy Press, Washington, DC.
52. Pathre, S. V., and C. J. Mirocha, 1979. Trichothecenes: Natural occurrence and potential hazard. J. Am. Oil Chem. Soc. 56: 820-823.
53. Riley, R. T., A. Nyeon-Hyoung, J. L. Showker, Y. Hwan-Soo, W. P. Norred, W. J. Chamberlain, E. Wang, A. H. Merrill, Jr., G. Motelin, V. R. Beasley, and W. M. Haschek, 1993. Alteration of tissue and serum sphinganine to sphingosine ratio: An early biomarker of exposure to fumonisin-containing feeds in pigs. Toxicol. Appl. Pharmacol. 118: 105-112.
54. Ross, P. F., P. E. Nelson, J. L. Richard, G. D. Osweiler, L. G. Rice, R. D. Plattner, and T. M. Wilson, 1990. Production of fumonisins by Fusarium moniliforme and Fusarium proliferatum isolates associated with equine leucoencephalomalacia and a pulmonary edema syndrome in swine. Appl. Environ. Microbiol. 56:3225-3226.
55. SAS Institute, 1987. SAS/STAT® Guide for Personal Computers. 6th ed. SAS Institute Inc., Cary, NC.
56. Snedecor, G. W., and W. G. Cochran, 1967. Pages 258-380 in: Statistical Methods. 6th ed. The Iowa State University Press, Ames, IA.
57. Tacke, B. K., and H. H. Casper, 1996. Determination of deoxynivalenol in wheat, barley, and malt by column cleanup and GC/ECD. J. Assoc. Off. Anal. Chem. Int. 79: 472-475.
58. Tietz, N., 1976. Fundamentals of Clinical Chemistry. W. B. Saunders, Philadelphia, PA.
59. Trenholm, H. L., W. P. Cochrane, H. Cohen, J. I. Elliot, E. R. Farnworth, D. W. Friend, R.M.G. Hamilton, J. F. Standish, and B. K. Thompson, 1983. Survey of vomitoxin contamination of 1980 Ontario white winter wheat crop: results of survey and feeding trials. J. Assoc. Off. Anal. Chem. 66: 92-97.
60. Tung, H. T., R. D. Wyatt, P. Thaxton, and P. B. Hamilton, 1975. Concentrations of serum proteins during aflatoxicosis. Toxicol. Appl. Pharmacol. 34:320-326.
61. Vesonder, R. F., A. Ciegler, A. H. Jensen, 1973. Isolation of the emetic principle from Fusarium-infected corn. Appl. Microbiol. 26:1008-1010.
62. Vesonder, R. F., A. Ciegler, A. H. Jensen, W. K. Rohwedder, and D. Weisleder, 1976. Co-identity of the refusal and emetic principle from Fusarium-infected corn. Appl. Environ. Microbiol. 31:280-285.
63. Vesonder, R. F., A. Ciegler, R. F. Roger, K. A. Burbridge, R. J. Bothast, and A. H. Jensen, 1978. Survey of 1977 corn year preharvest corn for vomitoxin. Appl. Environ. Microbiol. 36:885-888.
64. Wang, E., W. P. Norred, C. W. Bacon, R. T. Riley, and A. H. Merrill, Jr., 1991. Inhibition of sphingolipid biosynthesis by fumonisins: Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266:14486-14490.
65. 1 in the young turkey. Poultry Sci. 73:1517-1525.
66. 1, on the young broiler chick. Poultry Sci. 72:456-466.
67. Weibking, T. S., D. R. Ledoux, A. J. Bermudez, J. R. Turk, and G. E. Rottinghaus, 1995. Effects on turkey poults of feeding Fusarium moniliforme M-1325 culture material grown under different environmental conditions. Avian Dis. 39:32-38.
68. Weibking, T. S., D. R. Ledoux, T. P. Brown, and G. E. Rottinghaus, 1993b. Fumonisin toxicity in turkeys. J. Vet. Diagn. Invest. 5:75-83.
69. 1 levels associated with an epizootic of equine leukoencephalomalacia. J. Vet. Diagn. Invest. 2:213-216.
70. Wyatt, R. D., W. M. Colwell, P. B. Hamilton, and H. R. Burmeister, 1973a. Neural disturbances in chickens caused by dietary T-2 toxin. Appl. Microbiol. 26:757-761.
71. Wyatt, R. D., P. B. Hamilton, and H. R. Burmeister, 1973b. The effects of T-2 toxin in broiler chickens. Poultry Sci. 52: 1853-1859.
72. Wyatt, R. D., P. B. Hamilton, and H. R. Burmeister, 1975. Altered feathering of chicks caused by T-2 toxin. Poultry Sci. 54:1042-1045.
73. Wyatt, R. D., B. A. Weeks, P. B. Hamilton, and H. R. Burmeister, 1972. Severe oral lesions in chickens caused by ingestion of dietary fusariotoxin T-2. Appl. Microbiol. 24: 251-257.