Studies on the assembly of a leucine zipper antibacterial peptide and its analogs onto mammalian cells and bacteria

Amino Acids

Volumn 40, Issue 2, 2011, Pages 749-759

  Ahmad, Aqeel ^a   Azmi, Sarfuddin ^a   Ghosh, Jimut Kanti ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antimicrobial peptides, bactericidal and cytotoxic activity; Assembly and oligomerization of antibacterial peptides; Cellular interactions; Leucine zipper motif; Peptide induced depolarization and damage of membrane organization of bacteria and mammalian cells

Indexed keywords

ALANINE; AMPHOLYTE; CHOLESTEROL; DOUBLE ALANINE DERIVATIVE; LEUCINE ZIPPER PROTEIN; PHOSPHATIDYLCHOLINE; POLYPEPTIDE ANTIBIOTIC AGENT; SINGLE ALANINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ARTIFICIAL MEMBRANE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CELL INTERACTION; CELL MEMBRANE DEPOLARIZATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; MEMBRANE DAMAGE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; CELL MEMBRANE; ERYTHROCYTES; ESCHERICHIA COLI; HUMANS; LEUCINE ZIPPERS; MICE; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; PEPTIDES; STAPHYLOCOCCUS AUREUS;

ESCHERICHIA COLI; MAMMALIA; STAPHYLOCOCCUS AUREUS;

EID: 78751581724     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0744-7     Document Type: Article

References (41)

1. A Ahmad SP Yadav N Asthana K Mitra SP Srivastava JK Ghosh 2006 Utilization of an amphipathic leucine zipper sequence to design antibacterial peptides with simultaneous modulation of toxic activity against human red blood cells J Biol Chem 281 22029 22038 1:CAS:528:DC%2BD28XnsVOmsbg%3D 10.1074/jbc.M602378200 16717087 (Pubitemid 44181907)
2. A Ahmad N Asthana S Azmi RM Srivastava BK Pandey V Yadav JK Ghosh 2009 Structure-function study of cathelicidin-derived bovine antimicrobial peptide BMAP-28: design of its cell-selective analogs by amino acid substitutions in the heptad repeat sequences Biochim Biophys Acta 1788 2411 2420 1:CAS:528:DC%2BD1MXhtlWitr3P 10.1016/j.bbamem.2009.08.021 19735644
3. A Ahmad S Azmi RM Srivastava S Srivastava BK Pandey R Saxena VK Bajpai JK Ghosh 2009 Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity Biochemistry 48 10905 10917 1:CAS:528:DC%2BD1MXhtlegur3P 10.1021/bi9009874 19845398
4. N Asthana SP Yadav JK Ghosh 2004 Dissection of antibacterial and toxic activity of melittin: a leucine zipper motif plays a crucial role in determining its hemolytic activity but not antibacterial activity J Biol Chem 279 55042 55050 1:CAS:528:DC%2BD2cXhtFeis77I 10.1074/jbc.M408881200 15475354 (Pubitemid 40066496)
5. B Bilgicer K Kumar 2004 De novo design of defined helical bundles in membrane environments Proc Natl Acad Sci USA 101 15324 15329 1:CAS:528:DC%2BD2cXhtVKhsb3P 10.1073/pnas.0403314101 15486092 (Pubitemid 39441540)
6. HG Boman 1995 Peptide antibiotics and their role in innate immunity Annu Rev Immunol 13 61 92 1:CAS:528:DyaK2MXltFamtLc%3D 10.1146/annurev.iy.13.040195. 000425 7612236
7. Y Chen CT Mant SW Farmer RE Hancock ML Vasil RS Hodges 2005 Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index J Biol Chem 280 12316 12329 1:CAS:528: DC%2BD2MXislyht7k%3D 10.1074/jbc.M413406200 15677462
8. JK Ghosh D Shaool P Guillaud L Ciceron D Mazier I Kustanovich Y Shai A Mor 1997 Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis J Biol Chem 272 31609 31616 1:CAS:528:DyaK2sXotVSktLo%3D 10.1074/jbc.272.50.31609 9395500 (Pubitemid 28013305)
9. KS Giddings AE Johnson RK Tweten 2003 Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins Proc Natl Acad Sci USA 100 11315 11320 1:CAS:528:DC%2BD3sXotFKmsrs%3D 10.1073/pnas.2033520100 14500900 (Pubitemid 37205932)
10. E Glukhov M Stark LL Burrows CM Deber 2005 Basis for selectivity of cationic antimicrobial peptides for bacterial versus mammalian membranes J Biol Chem 280 33960 33967 1:CAS:528:DC%2BD2MXhtVKisbnF 10.1074/jbc.M507042200 16043484 (Pubitemid 41443116)
11. RE Hancock 1997 Peptide antibiotics Lancet 349 418 422 1:CAS:528:DyaK2sXhvVamur0%3D 10.1016/S0140-6736(97)80051-7 9033483 (Pubitemid 27077684)
12. RE Hancock HG Sahl 2006 Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Nat Biotechnol 24 1551 1557 1:CAS:528:DC%2BD28Xht12gtbvM 10.1038/nbt1267 17160061 (Pubitemid 44967479)
13. A Hawrani RA Howe TR Walsh CE Dempsey 2008 Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides J Biol Chem 283 18636 18645 1:CAS:528:DC%2BD1cXnsl2ru7c%3D 10.1074/jbc. M709154200 18434320
14. K Hilpert R Volkmer-Engert T Walter RE Hancock 2005 High-throughput generation of small antibacterial peptides with improved activity Nat Biotechnol 23 1008 1012 1:CAS:528:DC%2BD2MXntVSrtro%3D 10.1038/nbt1113 16041366 (Pubitemid 41114036)
15. MM Javadpour MD Barkley 1997 Self-assembly of designed antimicrobial peptides in solution and micelles Biochemistry 36 9540 9549 1:CAS:528: DyaK2sXksleltLg%3D 10.1021/bi961644f 9236000 (Pubitemid 27346995)
16. Y Lai RL Gallo 2009 AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense Trends Immunol 30 131 141 1:CAS:528: DC%2BD1MXivVertr8%3D 10.1016/j.it.2008.12.003 19217824
17. WF Li GX Ma XX Zhou 2006 Apidaecin-type peptides: biodiversity, structure-function relationships and mode of action Peptides 27 2350 2359 1:CAS:528:DC%2BD28Xot1Wksb0%3D 10.1016/j.peptides.2006.03.016 16675061 (Pubitemid 44189613)
18. LP Liu CM Deber 1998 Uncoupling hydrophobicity and helicity in transmembrane segments. Alpha-helical propensities of the amino acids in non-polar environments J Biol Chem 273 23645 23648 1:CAS:528:DyaK1cXmtFOktLY%3D 10.1074/jbc.273.37.23645 9726967 (Pubitemid 28435691)
19. Z Luo AM Matthews SR Weiss 1999 Amino acid substitutions within the leucine zipper domain of the murine coronavirus spike protein cause defects in oligomerization and the ability to induce cell-to-cell fusion J Virol 73 8152 8159 1:CAS:528:DyaK1MXlvFyrtrk%3D 10482565
20. JR Luque-Ortega W van't Hof EC Veerman JM Saugar L Rivas 2008 Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania FASEB J 22 1817 1828 1:CAS:528:DC%2BD1cXntlOhsbY%3D 10.1096/fj.07-096081 18230684 (Pubitemid 351811459)
21. AK Mahalka PK Kinnunen 2009 Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: lessons from temporins B and L Biochim Biophys Acta 1788 1600 1609 1:CAS:528:DC%2BD1MXnt1GhtLw%3D 10.1016/j.bbamem.2009.04.012 19394305
22. R Mani SD Cady M Tang AJ Waring RI Lehrer M Hong 2006 Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR Proc Natl Acad Sci USA 103 16242 16247 1:CAS:528:DC%2BD28Xht1WmsL3I 10.1073/pnas.0605079103 17060626 (Pubitemid 44715181)
23. AK Marr WJ Gooderham RE Hancock 2006 Antibacterial peptides for therapeutic use: obstacles and realistic outlook Curr Opin Pharmacol 6 468 472 1:CAS:528:DC%2BD28XpsVWrs7s%3D 10.1016/j.coph.2006.04.006 16890021 (Pubitemid 44340665)
24. E Nagoshi Y Yoneda 2001 Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta Mol Cell Biol 21 2779 2789 1:CAS:528:DC%2BD3MXisVyhsbg%3D 10.1128/MCB.21.8.2779-2789.2001 11283257 (Pubitemid 32244922)
25. P Nicolas 2009 Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides FEBS J 276 6483 6496 1:CAS:528:DC%2BD1MXhsVSmsL3J 10.1111/j.1742-4658.2009.07359.x 19817856
26. Z Oren Y Shai 1997 Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: structure-function study Biochemistry 36 1826 1835 1:CAS:528:DyaK2sXhsVSlu70%3D 10.1021/bi962507l 9048567 (Pubitemid 27086279)
27. Z Oren JC Lerman GH Gudmundsson B Agerberth Y Shai 1999 Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity Biochem J 341 Pt 3 501 513 1:CAS:528:DyaK1MXltlarurk%3D 10.1042/0264-6021:3410501 10417311 (Pubitemid 29389178)
28. L Otvos Jr JD Wade F Lin BA Condie J Hanrieder R Hoffmann 2005 Designer antibacterial peptides kill fluoroquinolone-resistant clinical isolates J Med Chem 48 5349 5359 1:CAS:528:DC%2BD2MXmt1Wku74%3D 10.1021/jm050347i 16078852 (Pubitemid 41114906)
29. YL Pan JT Cheng J Hale J Pan RE Hancock SK Straus 2007 Characterization of the structure and membrane interaction of the antimicrobial peptides aurein 2.2 and 2.3 from Australian southern bell frogs Biophys J 92 2854 2864 1:CAS:528:DC%2BD2sXkt1Cnsr0%3D 10.1529/biophysj.106.097238 17259271 (Pubitemid 46557859)
30. N Papo Y Shai 2005 A molecular mechanism for lipopolysaccharide protection of Gram-negative bacteria from antimicrobial peptides J Biol Chem 280 10378 10387 1:CAS:528:DC%2BD2MXit1ersrY%3D 10.1074/jbc.M412865200 15632151 (Pubitemid 40395894)
31. A Patrzykat CL Friedrich L Zhang V Mendoza RE Hancock 2002 Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli Antimicrob Agents Chemother 46 605 614 1:CAS:528:DC%2BD38XhsVKht7o%3D 10.1128/AAC.46.3.605-614.2002 11850238 (Pubitemid 34162506)
32. E Podda M Benincasa S Pacor F Micali M Mattiuzzo R Gennaro M Scocchi 2006 Dual mode of action of Bac7, a proline-rich antibacterial peptide Biochim Biophys Acta 1760 1732 1740 1:CAS:528:DC%2BD28XhtFOjtLnI 17059867
33. R Richie-Jannetta SH Francis JD Corbin 2003 Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function J Biol Chem 278 50070 50079 1:CAS:528:DC%2BD3sXpslSqs7g%3D 10.1074/jbc.M306796200 12933804 (Pubitemid 37548844)
34. RK Tweten RW Harris PJ Sims 1991 Isolation of a tryptic fragment from Clostridium perfringens theta-toxin that contains sites for membrane binding and self-aggregation J Biol Chem 266 12449 12454 1:CAS:528:DyaK3MXltVyhtrY%3D 2061320
35. SP Yadav B Kundu JK Ghosh 2003 Identification and characterization of an amphipathic leucine zipper-like motif in Escherichia coli toxin hemolysin E. Plausible role in the assembly and membrane destabilization J Biol Chem 278 51023 51034 1:CAS:528:DC%2BD3sXpslOhs7s%3D 10.1074/jbc.M310052200 14525984 (Pubitemid 38020336)
36. SP Yadav A Ahmad BK Pandey R Verma JK Ghosh 2008 Inhibition of lytic activity of Escherichia coli toxin hemolysin E against human red blood cells by a leucine zipper peptide and understanding the underlying mechanism Biochemistry 47 2134 2142 1:CAS:528:DC%2BD1cXps1GltQ%3D%3D 10.1021/bi701187e 18217774 (Pubitemid 351287139)
37. SP Yadav A Ahmad BK Pandey D Singh N Asthana R Verma RK Tripathi JK Ghosh 2009 A peptide derived from the putative transmembrane domain in the tail region of E. coli toxin hemolysin E assembles in phospholipid membrane and exhibits lytic activity to human red blood cells: plausible implications in the toxic activity of the protein Biochim Biophys Acta 1788 538 550 1:CAS:528:DC%2BD1MXhsFKlsLg%3D 10.1016/j.bbamem.2008.11.013 19111524
38. MR Yeaman NY Yount 2007 Unifying themes in host defence effector polypeptides Nat Rev Microbiol 5 727 740 1:CAS:528:DC%2BD2sXptFyrsrc%3D 10.1038/nrmicro1744 17703227 (Pubitemid 47278866)
39. M Zasloff 2002 Antimicrobial peptides of multicellular organisms Nature 415 389 395 1:CAS:528:DC%2BD38XhtVCgsLs%3D 10.1038/415389a 11807545 (Pubitemid 34100944)
40. M Zasloff 2006 Inducing endogenous antimicrobial peptides to battle infections Proc Natl Acad Sci USA 103 8913 8914 1:CAS:528:DC%2BD28XmsVSqu74%3D 10.1073/pnas.0603508103 16754884 (Pubitemid 43902508)
41. L Zhang A Rozek RE Hancock 2001 Interaction of cationic antimicrobial peptides with model membranes J Biol Chem 276 35714 35722 1:CAS:528: DC%2BD3MXntFahsbg%3D 10.1074/jbc.M104925200 11473117