Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: The role of leucine as well as phenylalanine zipper sequences in determining its toxicity

Biochemistry

Volumn 48, Issue 46, 2009, Pages 10905-10917

  Ahmad, Aqeel ^a   Azmi, Sarfuddin ^a   Srivastava, Raghvendra M ^a   Srivastava, Saurabh ^a   Pandey, Brijesh K ^a   Saxena, Rubha ^a   Bajpai, Virendra Kumar ^a   Ghosh, Jimut Kanti ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ANTI-BACTERIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; CATHELICIDIN; CYTOTOXIC ACTIVITIES; GRAM-NEGATIVE BACTERIA; LEUCINE ZIPPERS; MAMMALIAN CELLS; NATURALLY OCCURRING; PHENYLALANINE RESIDUES; WILD TYPES;

AMINES; BACTERIA; BACTERIOLOGY; CYTOTOXICITY; MAMMALS; ORGANIC ACIDS; PEPTIDES; POLYPEPTIDES; TRANSCRIPTION FACTORS;

AMINO ACIDS;

BMAP 27; CATHELICIDIN; LEUCINE ZIPPER PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANILINO NAPHTHALENESULFONATES; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CATTLE; CELL MEMBRANE; CELL SURVIVAL; DRUG DESIGN; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEMOLYSIS; HUMANS; LEUCINE ZIPPERS; LIPOSOMES; MEMBRANE POTENTIALS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; PERMEABILITY; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; PROTEINS; SPECTROMETRY, FLUORESCENCE;

BACTERIA (MICROORGANISMS); BOVINAE; MAMMALIA; MURINAE; NEGIBACTERIA; POSIBACTERIA;

EID: 72749118747     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9009874     Document Type: Article

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