Utilization of an amphipathic leucine zipper sequence to design antibacterial peptides with simultaneous modulation of toxic activity against human red blood cells

Journal of Biological Chemistry

Volumn 281, Issue 31, 2006, Pages 22029-22038

  Ahmad, Aqeel ^a   Yadav, Sharada Prasad ^a   Asthana, Neeta ^a   Mitra, Kalyan ^a   Srivastava, Swati Prakash ^a   Ghosh, Jimut Kanti ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BLOOD; CELLS; DRUG PRODUCTS; SYNTHESIS (CHEMICAL); TOXICITY;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL PEPTIDES; LEUCINE ZIPPER PEPTIDES (LZP); LEUCINE ZIPPER SEQUENCE;

AMINO ACIDS;

ALANINE; AMPHOLYTE; ANTIINFECTIVE AGENT; LEUCINE ZIPPER PEPTIDE; LEUCINE ZIPPER PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONFOCAL MICROSCOPY; CYTOTOXICITY; ERYTHROCYTE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HUMAN; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; ERYTHROCYTES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; LEUCINE ZIPPERS; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA;

EID: 33746807690     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602378200     Document Type: Article

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