Structure-function study of cathelicidin-derived bovine antimicrobial peptide BMAP-28: Design of its cell-selective analogs by amino acid substitutions in the heptad repeat sequences

Biochimica et Biophysica Acta - Biomembranes

Volumn 1788, Issue 11, 2009, Pages 2411-2420

  Ahmad, Aqeel ^a   Asthana, Neeta ^a   Azmi, Sarfuddin ^a   Srivastava, Raghvendra M ^a   Pandey, Brijesh K ^a   Yadav, Vikas ^a   Ghosh, Jimut Kanti ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antimicrobial and toxic activity; Antimicrobial peptide; Leucine zipper motif; Localization of antimicrobial peptides onto bacterial and mammalian cells; Peptide membrane interaction

Indexed keywords

CATHELICIDIN; ISOLEUCINE; LEUCINE; MELITTIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN BMAP 28; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; COW; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; ERYTHROCYTE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; MAMMAL CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN MOTIF; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; WILD TYPE;

3T3 CELLS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTI-BACTERIAL AGENTS; CATTLE; CELL MEMBRANE; ERYTHROCYTES; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); BOVINAE; ESCHERICHIA COLI; MAMMALIA;

EID: 71149113168     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2009.08.021     Document Type: Article

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