Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin β

Molecular and Cellular Biology

Volumn 21, Issue 8, 2001, Pages 2779-2789

  Nagoshi, E ^a   Yoneda, Y ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; KARYOPHERIN; KARYOPHERIN BETA; LEUCINE; LEUCINE ZIPPER PROTEIN; MUTANT PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CROSS LINKING; DIMERIZATION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

ALPHA KARYOPHERINS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELL NUCLEUS; DIMERIZATION; DNA PRIMERS; DNA-BINDING PROTEINS; HELA CELLS; HELIX-LOOP-HELIX MOTIFS; HUMANS; KARYOPHERINS; LEUCINE ZIPPERS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTORS;

EID: 0035080226     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.8.2779-2789.2001     Document Type: Article

References (54)

1. Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
2. Interactions of coiled coils in transcription factors: Where is the specificity?
3. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: A mechanism for cytoplasmic retention
4. The leucine zipper is necessary for stabilizing a dimer of the helix-loop-helix transcription factor USF but not for maintenance of an elongated conformation
5. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
6. Structure of importin-beta bound to the IBB domain of importin-alpha
7. Nucleocytoplasmic transport of macromolecules
8. Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
9. DNA recognition by helix-loop-helix proteins
10. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
11. A 41 amino acid motif in importin-alpha confers binding to importin- beta and hence transit into the nucleus
12. Transport between the cell nucleus and the cytoplasm
13. Nucleocytoplasmic transport
14. Identification of different roles for RanGDP and RanGTP in nuclear protein import
15. Interactions between HIV Rev and nuclear import and export factors: The Rev nuclear localization signal mediates specific binding to human importin-beta
16. A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells
17. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure
18. The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile
19. A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding
20. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
21. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
22. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
23. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
24. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
25. Ran-unassisted nuclear migration of a 97-kD component of nuclear poretargeting complex
26. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
27. Identification of a tRNA-specific nuclear export receptor
28. The N-terminal domain of IκB alpha masks the nuclear localization signal(s) of p50 and c-Rel homodimers
29. Analysis of the Myc and Max interaction specificity with lambda repressor-HLH domain fusions
30. Nucleocytoplasmic transport: The soluble phase
31. Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip
32. Transport of proteins and RNAs in and out of the nucleus
33. Nucleocytoplasmic transport: Signals, mechanisms and regulation
34. Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha
35. Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 Å resolution
36. Transport routes through the nuclear pore complex
37. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
38. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
39. mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization
40. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein
41. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein: Evidence from in vivo competition studies
42. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells
43. Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2
44. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1
45. Interferon-γ-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4
46. Exogenously injected nuclear import factor p10/NTF2 inhibits signal- mediated nuclear import and export of proteins in living cells
47. The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals
48. Structural view, of the Ran-Importin beta interaction at 2.3 Å resolution
49. The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import
50. Karyopherins and kissing cousins
51. How proteins are transported from cytoplasm to the nucleus
52. Nucleocytoplasmic protein traffic and its significance to cell function
53. Nucleocytoplasmic protein transport and recycling of Ran