Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 9, 2004, Pages 4351-4358

  Paddon Jones, Douglas ^a,b,c   Sheffield Moore, Melinda ^a,b   Urban, Randall J ^a   Sanford, Arthur P ^b   Aarsland, Asle ^a,b   Wolfe, Robert R ^a,b   Ferrando, Arny A ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

^c Metabolism Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; ESSENTIAL AMINO ACID; PHENYLALANINE;

ADULT; ARTICLE; BED REST; BLOOD SAMPLING; CARBOHYDRATE INTAKE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMORAL ARTERY FLOW; HUMAN; HUMAN EXPERIMENT; IMMOBILIZATION STRESS; LEAN BODY WEIGHT; LEG MUSCLE; MALE; MUSCLE BIOPSY; MUSCLE STRENGTH; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN INTAKE; VASTUS LATERALIS MUSCLE;

NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER;

ADULT; AMINO ACIDS, ESSENTIAL; BED REST; BLOOD GLUCOSE; BODY COMPOSITION; DIETARY CARBOHYDRATES; DIETARY SUPPLEMENTS; HUMANS; INSULIN; MALE; MIDDLE AGED; MUSCLE PROTEINS; PHENYLALANINE;

EID: 4544351389     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-032159     Document Type: Article

References (39)

1. Bettany GE, Ang BC, Georgiannos SN, Halliday D, Powell-Tuck J 1996 Bed rest decreases whole-body protein turnover in post-absorptive man. Clin Sci 90:73-75
2. Ferrando AA, Stuart CS, Sheffield-Moore M, Wolfe RR 1999 Inactivity amplifies the catabolic response of skeletal muscle to cortisol. J Clin Endocrinol Metab 84:3515-3521
3. Stuart CA, Shangraw RE, Peters EJ, Wolfe RR 1990 Effect of dietary protein on bed-rest-related changes in whole-body-protein synthesis. Am J Clin Nutr 52:509-514
4. Ferrando AA, Lane HW, Stuart CA, Wolfe RR 1996 Prolonged bed rest decreases skeletal muscle and whole-body protein synthesis. Am J Physiol 270:E627-E633
5. LeBlanc AD, Gogia P, Scheider V, Krebs J, Schonfeld E, Evans H 1988 Calf muscle area and strength changes after five weeks of horizontal bed rest. Am J Sports Med 16:624-629
6. LeBlanc AD, Schneider VS, Evans HJ, Pientok C, Rowe R, Spector E 1992 Regional changes in muscle mass following 17 weeks of bed rest. J Appl Physiol 73:2171-2178
7. Shangraw RE, Stuart CA, Prince MJ, Peters EJ, Wolfe RR 1988 Insulin responsiveness of protein metabolism in vivo following bedrest in humans. Am J Physiol 255:E548-E558
8. Stein TP, Schluter MD, Leskiw MJ, Boden G 1999 Attenuation of the protein wasting associated with bed rest by branched-chain amino acids. Nutrition 15:656-660
9. Bamman MM, Clarke MS, Feeback DL, Talmadge RJ, Stevens BR, Lieberman SA, Greenisen MC 1998 Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution. J Appl Physiol 84:157-163
10. Ferrando AA, Tipton KD, Bamman MM, Wolfe RR 1997 Resistance exercise maintains skeletal muscle protein synthesis during bed rest. J Appl Physiol 82:807-810
11. May ME, Buse MG 1989 Effects of branched-chain amino acids on protein turnover. Diabetes Metab Rev 5:227-245
12. Paddon-Jones D, Sheffield-Moore M, Zhang XJ, Volpi E, Wolf SE, Aarsland A, Ferrando AA, Wolfe RR 2004 Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol (Endocrinol Metab) 286:E321-E328
13. Borsheim E, Tipton KD, Wolf SE, Wolfe RR 2002 Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab 283:E648-E657
14. Tipton KD, Gurki BE, Matin S, Wolfe RR 1999 Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J Nutr Biochem 10:89-95
15. Fiatarone Singh MA, Bernstein MA, Ryan AD, O'Neill EF, Clements KM, Evans WJ 2000 The effect of oral nutritional supplements on habitual dietary quality and quantity in frail elders. J Nutr Health Aging 4:5-12
16. Borsheim E, Cree MG, Tipton KD, Elliott TA, Aarsland A, Wolfe RR 2004 Effect of carbohydrate intake on net muscle protein synthesis during recovery from resistance exercise. J Appl Physiol 96:674-678
17. Wolfe RR, Volpi E 2001 Insulin and protein metabolism. In: Jefferson L, Cherrington A, eds. Handbook of physiology. Oxford: New York; 735-757
18. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR 2000 The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 85:4481-4490
19. Miller SL, Tipton KD, Chinkes DL, Wolf SE, Wolfe RR 2003 Independent and combined effects of amino acids and glucose after resistance exercise. Med Sci Sports Exerc 35:449-455
20. Ferrando AA, Stuart CA, Brunder DG, Hillman GR 1995 Magnetic resonance imaging quantitation of changes in muscle volume during 7 days of strict bed rest. Aviat Space Environ Med 66:976-981
21. Jorfeld L, Warhen J 1971 Leg blood flow during exercise in man. Clin Sci 41:459-473
22. Biolo G, Fleming DY, Maggi S, Wolfe RR 1995 Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol 268:E75-E84
23. Bergstrom J 1975 Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 35:609-616
24. Paddon-Jones D, Sheffield-Moore M, Creson DL, Sanford AP, Wolf SE, Wolfe RR, Ferrando AA 2003 Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids. Am J Physiol 284:E946-E953
25. Bessey PQ, Jiang ZM, Johnson DJ, Smith RJ, Wilmore DW 1989 Posttraumatic skeletal muscle proteolysis: the role of the hormonal environment. World J Surg 13:465-471
26. Zhang X, Chinkes DL, Sakurai Y, Wolfe RR 1996 An isotopic method for measurement of muscle protein fractional breakdown rate in vivo. Am J Physiol 270:E759-E767
27. Patterson BW 1997 Use of stable isotopically labeled tracers for studies of metabolic kinetics: an overview. Metabolism 46:322-329
28. Wolfe RR 1992 Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis. New York: Wiley-Liss
29. Bergstrom J, Furst P, Noree LO, Vinnars E 1974 Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 36:693-697
30. 5-phenylalanine enrichment (0.002-0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spectrometry. Rapid Commun Mass Spectr 6:421-424
31. Pitt RF 1971 Physiology of the kidney and body fluids. 2nd ed. Chicago: Year Book
32. Baumann PQ, Stirewalt WS, O'Rourke BD, Howard D, Nair KS 1994 Precursor pools of protein synthesis: a stable isotope study in a swine model. Am J Physiol 267:E203-E209
33. Akima H, Kubo K, Imai M, Kanehisa H, Suzuki Y, Gunji A, Fukunaga T 2001 Inactivity and muscle: effect of resistance training during bed rest on muscle size in the lower limb. Acta Physiol Scand 172:269-278
34. Akima H, Ushiyama JI, Kubo J, Tonosaki SI, Itoh M, Kawakami Y, Fukuoka H, Kanehisa H, Fukunaga T 2003 Resistance training during unweighting maintains muscle size and function in human calf. Med Sci Sports Exerc 35:655-662
35. Germain P, Guell A, Marini JF 1995 Muscle strength during bedrest with and without muscle exercise as a countermeasure. Eur J Appl Physiol Occup Physiol 71:342-348
36. Tipton KD, Ferrando AA, Phillips SM, Doyle D, Wolfe RR 1999 Post-exercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol 276:E628-E634
37. Volpi E, Mittendorfer B, Wolf SE, Wolfe RR 1999 Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol 277:E513-E520
38. Stein TP, Schluter MD 1997 Human skeletal muscle protein breakdown during spaceflight. Am J Physiol 272:E688-E695
39. Tobin BW, Uchakin PN, Leeper-Woodford SK 2002 Insulin secretion and sensitivity in space flight: diabetogenic effects. Nutrition 18:842-848