Iron overload and diabetes risk: A shift from glucose to fatty acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis

Diabetes

Volumn 60, Issue 1, 2011, Pages 80-87

  Huang, Jingyu ^a   Jones, Deborah ^a   Luo, Bai ^a   Sanderson, Michael ^a   Soto, Jamie ^a   Abel, E Dale ^a   Cooksey, Robert C ^a,b   McClain, Donald A ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; FATTY ACID; FERRITIN; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IRON; MESSENGER RNA; PROTEIN KINASE B; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENE; GENE DELETION; GENE MUTATION; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE OXIDATION; HEMOCHROMATOSIS; HFE GENE; HYPERMETABOLISM; IN VITRO STUDY; IN VIVO STUDY; IRON OVERLOAD; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; SKELETAL MUSCLE;

ANIMALS; CYCLOPHILINS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DNA PRIMERS; GENE DELETION; GLUCONEOGENESIS; GLUCOSE; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INSULIN-SECRETING CELLS; IRON OVERLOAD; LIVER; MEMBRANE PROTEINS; MICE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DEHYDROGENASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; RISK FACTORS; RNA;

EID: 78751557145     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0593     Document Type: Article

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