Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis

Metabolism: Clinical and Experimental

Volumn 59, Issue 3, 2010, Pages 380-384

  Hatunic, Mensud ^a   Finucane, Francis M ^a   Brennan, Aoife M ^a   Norris, Suzanne ^a   Pacini, Giovanni ^b   Nolan, John J ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INSULIN;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEMOCHROMATOSIS; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; AGED; ANTHROPOMETRY; AREA UNDER CURVE; BLOOD GLUCOSE; C-PEPTIDE; FEMALE; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HEMOCHROMATOSIS; HUMANS; IRELAND; IRON OVERLOAD; MALE; MIDDLE AGED; PANCREATIC FUNCTION TESTS; PROSPECTIVE STUDIES;

EID: 76249132616     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.08.006     Document Type: Article

References (35)

1. Merryweather-Clarke A.T., Pointon J.J., Jouanolle A.M., Rochette J., and Robson K.J. Geography of HFE C282Y and H63D mutations. Genet Test 4 (2000) 183-198
2. Bacon B.R., Powell L.W., Adams P.C., Kresina T.F., and Hoofnagle J.H. Molecular medicine and hemochromatosis: at the crossroads. Gastroenterology 116 (1999) 193-207
3. Ryan E., O'Keane C., and Crowe J. Hemochromatosis in Ireland and HFE. Blood Cells Mol Dis 24 (1998) 428-432
4. Byrnes V., Ryan E., Barrett S., Kenny P., Mayne P., and Crowe J. Genetic hemochromatosis, a Celtic disease: is it now time for population screening?. Genet Test 5 (2001) 127-130
5. Merryweather-Clarke A.T., Pointon J.J., Shearman J.D., and Robson K.J. Global prevalence of putative haemochromatosis mutations. J Med Genet 34 (1997) 275-278
6. Feder J.N., Penny D.M., Irrinki A., Lee V.K., Lebron J.A., Watson N., et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A 95 (1998) 1472-1477
7. Feder J.N., Tsuchihashi Z., Irrinki A., Lee V.K., Mapa F.A., Morikang E., et al. The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J Biol Chem 272 (1997) 14025-14028
8. Edwards C.Q., Dadone M.M., Skolnick M.H., and Kushner J.P. Hereditary haemochromatosis. Clin Haematol 11 (1982) 411-435
9. Powell LW, Yapp TR. Hemochromatosis. Clin Liver Dis 2000;4:211-28, viii.
10. Ferrannini E. Insulin resistance, iron, and the liver. Lancet 355 (2000) 2181-2182
11. Cooksey R.C., Jouihan H.A., Ajioka R.S., Hazel M.W., Jones D.L., Kushner J.P., et al. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology 145 (2004) 5305-5312
12. Hramiak I.M., Finegood D.T., and Adams P.C. Factors affecting glucose tolerance in hereditary hemochromatosis. Clin Invest Med 20 (1997) 110-118
13. Niederau C., Berger M., Stremmel W., Starke A., Strohmeyer G., Ebert R., et al. Hyperinsulinaemia in non-cirrhotic haemochromatosis: impaired hepatic insulin degradation?. Diabetologia 26 (1984) 441-444
14. Ford E.S., and Cogswell M.E. Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care 22 (1999) 1978-1983
15. Wolff S.P. Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br Med Bull 49 (1993) 642-652
16. Dymock I.W., Cassar J., Pyke D.A., Oakley W.G., and Williams R. Observations on the pathogenesis, complications and treatment of diabetes in 115 cases of haemochromatosis. Am J Med 52 (1972) 203-210
17. Niederau C. Diabetes mellitus in hemochromatosis. Z Gastroenterol Suppl 1 (1999) 22-32
18. Facchini F.S. Effect of phlebotomy on plasma glucose and insulin concentrations. Diabetes Care 21 (1998) 2190
19. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation (2006) Geneva: WHO
20. Katz A., Nambi S.S., Mather K., Baron A.D., Follmann D.A., Sullivan G., et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85 (2000) 2402-2410
21. Mari A., Pacini G., Murphy E., Ludvik B., and Nolan J.J. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24 (2001) 539-548
22. Abdul-Ghani M.A., Jenkinson C.P., Richardson D.K., Tripathy D., and DeFronzo R.A. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes 55 (2006) 1430-1435
23. Stadler M., Anderwald C., Karer T., Tura A., Kastenbauer T., Auinger M., et al. Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation: a sign of impaired beta-cell function?. Diabetes Care 29 (2006) 1031-1038
24. Ludvik B., Waldhausl W., Prager R., Kautzky-Willer A., and Pacini G. Mode of action of Ipomoea batatas (Caiapo) in type 2 diabetic patients. Metabolism 52 (2003) 875-880
25. O'Sullivan E.P., McDermott J.H., Murphy M.S., Sen S., and Walsh C.H. Declining prevalence of diabetes mellitus in hereditary haemochromatosis-the result of earlier diagnosis. Diabetes Res Clin Pract 81 (2008) 316-320
26. Is fasting glucose sufficient to define diabetes? Epidemiological data from 20 European studies. The DECODE-study group. European Diabetes Epidemiology Group. Diabetes epidemiology: collaborative analysis of diagnostic criteria in Europe. Diabetologia 42 (1999) 647-654
27. McClain D.A., Abraham D., Rogers J., Brady R., Gault P., Ajioka R., et al. High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis. Diabetologia 49 (2006) 1661-1669
28. Bulaj Z.J., Ajioka R.S., Phillips J.D., LaSalle B.A., Jorde L.B., Griffen L.M., et al. Disease-related conditions in relatives of patients with hemochromatosis. N Engl J Med 343 (2000) 1529-1535
29. Valenti L., Conte D., Piperno A., Dongiovanni P., Fracanzani A.L., Fraquelli M., et al. The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis. J Med Genet 41 (2004) 946-950
30. Andrews N.C. Disorders of iron metabolism. N Engl J Med 341 (1999) 1986-1995
31. Beard J.L. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 131 2S-2 (2001) 568S-579S [discussion 80S]
32. Oberley L.W. Free radicals and diabetes. Free Radic Biol Med 5 (1988) 113-124
33. Merkel P.A., Simonson D.C., Amiel S.A., Plewe G., Sherwin R.S., Pearson H.A., et al. Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N Engl J Med 318 (1988) 809-814
34. Wilson J.G., Lindquist J.H., Grambow S.C., Crook E.D., and Maher J.F. Potential role of increased iron stores in diabetes. Am J Med Sci 325 (2003) 332-339
35. Niederau C., Fischer R., Purschel A., Stremmel W., Haussinger D., and Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 110 (1996) 1107-1119