Regulatory B cells in autoimmune diseases and mucosal immune homeostasis

Autoimmunity

Volumn 44, Issue 1, 2011, Pages 58-68

  Li, Xiaoxiao ^a   Braun, Jonathan ^a   Wei, Bo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmune diseases; Immunoregulation; Molecular mechanism; Mucosal homeostasis; Regulatory B cells

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; HLA B ANTIGEN; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ARTHRITIS; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL INTERACTION; HOMEOSTASIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIGEN PRESENTATION; AUTOANTIBODIES; AUTOIMMUNE DISEASES; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CYTOKINES; HOMEOSTASIS; HUMANS; IMMUNITY, MUCOSAL; MICE;

EID: 78751540524     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916931003782189     Document Type: Review

References (89)

1. Katz SI, Parker D, Turk JL. B-cell suppression of delayed hypersensitivity reactions. Nature 1974;251(5475):550.
2. Bouaziz J-D, Yanaba K, Tedder TF. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev 2008;224(1):201-214.
3. Fillatreau S, Gray D, Anderton SM. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol 2008;8(5):391.
4. Mizoguchi A, Bhan AK. A case for regulatory B cells. J Immunol 2006;176(2):705-710.
5. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 1977;146(3):857-868.
6. Korganow A-S, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali J-L, Benoist C, Mathis D. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10(4):451.
7. Yanaba K, Hamaguchi Y, Venturi GM, Steeber DA, St. Clair EW, Tedder TF. B cell depletion delays collagen-induced arthritis in mice: Arthritis induction requires synergy between humoral and cell-mediated immunity. J Immunol 2007; 179(2):1369-1380.
8. Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003; 197(4):489-501.
9. Evans JG, Chavez-Rueda KV, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C. Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol 2007;178(12):7868-7878.
10. Gray M, Miles K, Salter D, Gray D, Savill J. Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells. Proc Natl Acad Sci USA 2007;104(35): 14080-14085.
11. Mauro CDC, Roger WM, Byung SK, Stephen DM. Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and theilers murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc Res Tech 1995;32(3):215-229.
12. Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, Bar-Or A, Panzara M, Sarkar N, Agarwal S, Langer-Gould A, Smith CH, HERMES Trial Group B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 2008;358(7):676-688. (Pubitemid 351240747)
13. Wolf SD, Dittel BN, Hardardottir F, Janeway CA, Jr. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 1996;184(6): 2271-2278.
14. Gonnella PA, Waldner HP, Weiner HL. B cell-deficient ({micro}MT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance. J Immunol 2001;166(7):4456-4464.
15. Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 2002;3(10):944.
16. Matsushita T, Yanaba K, Bouaziz J-D, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 2008;118(10):3420.
17. Anderson MS, Bluestone JA. The NOD mouse: A model of immune dysregulation. Ann Rev Immunol 2005;23(1): 447-485.
18. Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL. Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol 2001;167(2):1081-1089.
19. Hussain S, Delovitch TL. Intravenous transfusion of BCRactivated B cells protects NOD mice from type 1 diabetes in an IL-10-dependent manner. J Immunol 2007;179(11): 7225-7232.
20. Pettersson I, HinterbergerM, Mimori T, Gottlieb E, Steitz JA. The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies. J Biol Chem 1984;259(9):5907-5914.
21. Fatenejad S, Brooks W, Schwartz A, Craft J. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mplpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target. J Immunol 1994;152(11): 5523-5531.
22. Yan J, Mamula MJ. B and T cell tolerance and autoimmunity in autoantibody transgenic mice. Int Immunol 2002;14(8): 963-971.
23. Amano H, Amano E, Moll T, Marinkovic D, Ibnou-Zekri N, Martinez-Soria E, Semac I, Wirth T, Nitschke L, Izui S. The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. J Immunol 2003; 170(5):2293-2301.
24. Lenert P, Brummel R, Field EH, Ashman RF. TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production. J Clin Immunol 2005;25(1):29.
25. Brummel R, Lenert P. Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides. J Immunol 2005;174(4):2429-2434. (Pubitemid 40223993)
26. Madan R, Demircik F, Surianarayanan S, Allen JL, Divanovic S, Trompette A, Yogev N, Gu Y, Khodoun M, Hildeman D, Boespflug N, Fogolin MB, Grobe L, Greweling M, Finkelman FD, Cardin R, MohrsM,MullerW, Waisman A, Roers A, Karp CL. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol 2009;183(4):2312-2320.
27. Harris DP, Haynes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, Johnson LL, Swain SL, Lund FE. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol 2000;1(6):475.
28. Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002;16(2):219.
29. Spencer NF, Daynes RA. IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD52 B cells: Possible involvement in ageassociated cytokine dysregulation. Int Immunol 1997;9(5): 745-754.
30. Booth JS, Griebel PJ, Babiuk LA, Mutwiri GK. A novel regulatory B-cell population in sheep Peyers patches spontaneously secretes IL-10 and downregulates TLR9-induced IFN{alpha} responses. Mucosal Immunol 2009; 2(3):265.
31. Matsushita T, Fujimoto M, Hasegawa M, Komura K, Takehara K, Tedder TF, Sato S. Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response.Am J Pathol 2006;168(3): 812-821.
32. Watanabe R, Fujimoto M, Ishiura N, Kuwano Y, Nakashima H, Yazawa N, Okochi H, Sato S, Tedder TF, Tamaki K. CD19 expression in B cells is important for suppression of contact hypersensitivity. Am J Pathol 2007; 171(2):560-570.
33. Yanaba K, Bouaziz J-D, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008;28(5):639.
34. Riegert A, Bar-Or A. B-cell-derived interleukin-10 in autoimmune disease: Regulating the regulators. Nat Rev Immunol 2008;8(6):486.
35. Moulin V, Andris F, Thielemans K, Maliszewski C, Urbain J, Moser M. B lymphocytes regulate dendritic cell (DC) function in vivo: Increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation. J Exp Med 2000;192(4):475-482.
36. Mizoguchi E, Mizoguchi A, Preffer FI, Bhan AK. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 2000;12(5):597-605.
37. Takenoshita S, Fukushima T, Kumamoto K, Iwadate M. The role of TGF-b in digestive organ disease. J Gastroenterol 2002;37(12):991.
38. Parekh VV, Prasad DVR, Banerjee PP, Joshi BN, Kumar A, Mishra GC. B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: Role of TGF-{beta}1. J Immunol 2003;170(12): 5897-5911.
39. Deshpande SP, Zheng M, Daheshia M, Rouse BT. Pathogenesis of Herpes Simplex virus-induced ocular immunoinflammatory lesions in B-cell-deficient mice. J Virol 2000;74(8): 3517-3524.
40. Kang H, Remington JS, Suzuki Y. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-{gamma}, TNF-{alpha}, and inducible nitric oxide synthase. J Immunol 2000;164(5): 2629-2634.
41. Smelt SC, Cotterell SEJ, Engwerda CR, Kaye PM. B celldeficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology. J Immunol 2000;164(7):3681-3688.
42. Buendia AJ, Del Rio L, Ortega N, Sanchez J, Gallego MC, Caro MR, Navarro JA, Cuello F, Salinas J. B-cell-deficient mice show an exacerbated inflammatory response in a model of Chlamydophila abortus infection. Infect Immun 2002; 70(12):6911-6918.
43. Diamond MS, Shrestha B, Marri A, Mahan D, Engle M. B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. J Virol 2003;77(4):2578-2586.
44. Mizoguchi A, Mizoguchi E, Smith RN, Preffer FI, Bhan AK. Suppressive role of B cells in chronic colitis of T cell receptor {alpha} mutant mice. J Exp Med 1997;186(10):1749-1756.
45. Kalergis AM, Ravetch JV. Inducing tumor immunity through the selective engagement of activating Fc {gamma} receptors on dendritic cells. J Exp Med 2002;195(12):1653-1659.
46. Legge KL, Gregg RK, Maldonado-Lopez R, Li L, Caprio JC, Moser M, Zaghouani H. On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity. J Exp Med 2002;196(2):217-227.
47. Siragam V, Brinc D, Crow AR, Song S, Freedman J, Lazarus AH. Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease? J Clin Invest 2005; 115(1):155.
48. Casadevall A, Pirofski L-A. Antibody-mediated regulation of cellular immunity and the inflammatory response. Trends Immunol 2003;24(9):474.
49. Brigl M, Brenner MB. CD1: Antigen presentation and T cell function. Ann Rev Immunol 2004;22(1):817-890.
50. MacDonald HR. NK1.1+ T cell receptor-alpha/beta+ cells: New clues to their origin, specificity, and function. J Exp Med 1995;182(3):633-638.
51. Schofield L, McConville MJ, Hansen D, Campbell AS, Fraser-Reid B, Grusby MJ, Tachado SD. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science 1999;283(5399):225-229.
52. Chiu Y-H, Park S-H, Benlagha K, Forestier C, Jayawardena-Wolf J, Savage PB, Teyton L, Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat Immunol 2002;3(1):55.
53. Zhou D, Mattner J, Cantu C, III, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu Y-P, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, Teyton L, Bendelac A. Lysosomal glycosphingolipid recognition by NKT cells. Science 2004;306(5702):1786-1789.
54. Kinjo Y, Wu D, Kim G, Xing G-W, Poles MA, Ho DD, Tsuji M, Kawahara K, Wong C-H, Kronenberg M. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 2005;434(7032):520.
55. Mattner J, DeBord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB, Bendelac A. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 2005; 434(7032):525.
56. Borg NA, Wun KS, Kjer-Nielsen L, Wilce MCJ, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J, Rossjohn J. CD1d-lipid-antigen recognition by the semiinvariant NKT T-cell receptor. Nature 2007;448(7149):44.
57. Koh-Hei S, Joan S-S. CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur J Immunol 2002;32(3):848-857.
58. Miley MJ, Truscott SM, Yu YYL, Gilfillan S, Fremont DH, Hansen TH, Lybarger L. Biochemical features of the MHC-related protein 1 consistent with an immunological function. J Immunol 2003;170(12):6090-6098.
59. Parra-Cuadrado J, del Moral M, Garca-Pava P, Setién F, Martnez-Naves E. Characterization of the MHC class IRegulatory related MR1 locus in nonhuman primates. Immunogenetics 2001;53(8):643.
60. Riegert P, Wanner V, Bahram S. Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene. J Immunol 1998;161(8):4066-4077.
61. Hansen TH, Huang S, Arnold PL, Fremont DH. Patterns of nonclassical MHC antigen presentation. Nat Immunol 2007; 8(6):563.
62. Schümann J, De Libero G. MR1-restricted Valpha19i T cells -a second population recognizing lipid antigens? Eur J Immunol 2007;37(7):1724-1726.
63. Shimamura M, Huang Y-Y, Okamoto N, Suzuki N, Yasuoka J, Morita K, Nishiyama A, Amano Y, Mishina T. Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines. Eur J Immunol 2007;37(7):1836-1844.
64. Kawachi I, Maldonado J, Strader C, Gilfillan S. MR1-Restricted V{alpha}19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response. J Immunol 2006;176(3): 1618-1627.
65. Middendorp S, Nieuwenhuis EES. NKT cells in mucosal immunity. Mucosal Immunol 2009;2(5):393.
66. Treiner E, Duban L, Bahram S, Radosavljevic M, Wanner V, Tilloy F, Affaticati P, Gilfillan S, Lantz O. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 2003;422(6928):164.
67. Illes Z, Shimamura M, Newcombe J, Oka N, Yamamura T. Accumulation of V{alpha}7.2-J{alpha}33 invariant T cells in human autoimmune inflammatory lesions in the nervous system. Int Immunol 2004;6(2):223-230.
68. Nell LJ, Kastner DL, Rich RR. Qa-1-associated antigens. III. Distribution of Qa-1 region antigens on lymphoid subpopulations. J Immunol 1980;125(6):2597-2603.
69. Hu D, Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol 2004;5(5):516-523.
70. Jiang H, Braunstein NS, Yu B, Winchester R, Chess L. CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc Natl Acad Sci USA 2001;98(11): 6301-6306.
71. Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J. Resident enteric microbiota and CD8 + T cells shape the abundance of marginal zone B cells. Eur J Immunol 2008;38(12):3411-3425.
72. Fujiwara D, Wei B, Presley LL, Brewer S, McPherson M, Lewinski MA, Borneman J, Braun J. Systemic control of plasmacytoid dendritic cells by CD8 + T cells and commensal microbiota. J Immunol 2008;180(9):5843-5852.
73. Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Ann Rev Immunol 1998;16(1):111-135.
74. Quezada SA, Jarvinen LZ, Lind EF, Noelle RJ. CD40/CD154 interactions at the interface of tolerance and immunity. Ann Rev Immunol 2004;22(1):307-328.
75. Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 1996;97(9):2063.
76. Lehuen A, Lantz O, Beaudoin L, Laloux V, Carnaud C, Bendelac A, Bach J-F, Monteiro RC. Overexpression of natural killer T cells protects V{alpha}14-J{alpha}281 transgenic nonobese diabetic mice against diabetes. J Exp Med 1998;188(10):1831-1839.
77. Miyamoto K, Miyake S, Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001;413(6855):531.
78. Croxford JL, Miyake S, Huang Y-Y, Shimamura M, Yamamura T. Invariant Valpha19i T cells regulate autoimmune inflammation. Nat Immunol 2006;7(9):987.
79. Hornquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR. G{alpha}i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 1997;158(3):1068-1077.
80. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G, Bradley A, Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in G{alpha}i2-deficient mice. Nat Genet 1995;10(2):143.
81. Wei B, McPherson M, TurovskayaO, Velazquez P, FujiwaraD, Brewer S, Braun J. Integration of B cells and CD8 + T in the protective regulation of systemic epithelial inflammation. Clin Immunol 2008;127(3):303.
82. Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J. B cell developmental requirement for the G{alpha}i2 gene. J Immunol 2003; 170(4):1707-1715.
83. Wei B, Velazquez P, Turovskaya O, Spricher K, Aranda R, Kronenberg M, Birnbaumer L, Braun J. Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci USA 2005; 102(6)-2015.
84. McPherson M, Wei B, Turovskaya O, Fujiwara D, Brewer S, Braun J. Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol 2008;295(3): G485-G492.
85. Izcue A, Coombes J, Powrie F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev 2006;212(1):256-271.
86. Ken S, AtsuhiroO, Yasuyo S, Kiyotaka N, Atsushi M, Atul KB. Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology 2007;133(1):124.
87. Matthieu A, Jens B, Iris D, Lloyd M. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology 2002;123(5):1516.
88. Lilani P, Ling S, Anjlee P, Kelly E, Bertrand M, Richard B, Daniel G, Veronika G, Thomas S, Bana J, Lloyd M. Expression of nonclassical class I molecules by intestinal epithelial cells. Inflamm Bowel Dis 2007;13(3):298-307.
89. Malin B, Paul WB, Roger W, Hultgren HE. Long-term treatment with anti-α4 integrin antibodies aggravates colitis in G{alpha}i2-deficient mice. Eur J Immunol 2005; 35(8):2274-2283.