MR1-restricted Vα19i T cells - A second population recognizing lipid antigens?

European Journal of Immunology

Volumn 37, Issue 7, 2007, Pages 1724-1726

  Schümann, Jens ^a   De Libero, Gennaro ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Antigen presentation; Immune responses; Lipid reactive T cells

Indexed keywords

CD1D ANTIGEN; GAMMA INTERFERON; GLYCOLIPID; INTERLEUKIN 10; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; HLA ANTIGEN CLASS 1; LIPID; LYMPHOCYTE ANTIGEN RECEPTOR; MR1 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CARBOHYDRATE ANALYSIS; CYTOKINE RELEASE; HUMAN; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; ANIMAL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; NOTE;

ANIMALS; ANTIGEN PRESENTATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LIPIDS; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 34447573638     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737509     Document Type: Article

References (13)

1. Godfrey, D. I. and Kronenberg, M., Going both ways: Immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 2004. 114: 1379-1388.
2. Yu, K. O. A. and Porcelli, S. A., The diverse functions of CD1d-restricted NKT cells and their potential for immunotherapy. Immunol. Lett. 2005. 100: 42-55.
3. De Libero, G. and Mori, L., Recognition of lipid antigens by T cells. Nat. Rev. Immunol. 2005. 5: 485-496.
4. Treiner, E., Duban, L., Moura, I. C., Hansen, T., Gilfillan, S. and Lantz, O., Mucosal-associated invariant T (MAIT) cells: An evolutionarily conserved T cell subset. Microbes Infect. 2005. 7: 552-559.
5. Shimamura, M. and Huang, Y.-Y., Presence of a novel subset of NKT cells bearing an invariant Vα19.1-Jα26 TCR α chain. FEBS Lett. 2002. 516: 97-100.
6. Illés, Z., Shimamura, M., Newcombe, J., Oka, N. and Yamamura, T., Accumulation of Vα7.2-Jα33 invariant T cells in human autoimmune inflammatory lesions in the nervous system. Int. Immunol. 2004. 16: 223-230.
7. Treiner, E., Duban, L., Bahram, S., Radosavijevic, M., Wanner, V., Tilloy, F., Affaticati, P. et al., Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 2003. 422: 164-169.
8. α19i T cells regulate autoimmune inflammation. Nat. Immunol. 2006. 7: 987-994.
9. Kawachi, I., Maldonado, J., Strader, C. and Gilfillan, S., MR1-restricted Vα19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response. J. Immunol. 2006. 176: 1618-1627.
10. Okamoto, N., Kanie, O., Huang, Y.-Y., Fujii, R., Watanabe, H. and Shimamura, M., Synthetic α-mannosyl ceramide as a potent stimulant for an NKT cell repertoire bearing the invariant Vα19-Jα26 TCR α chain. Chem. Biol. 2005. 12: 677-683.
11. Shimamura, M., Okamoto, N., Huang, Y.-Y., YYasuoka, J., Morita, K., Nishiyama, A., Yuusuke, A. et al., Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Vα19 NKT cell with α-mannosyl ceramide analogues consisting of the immunosup-pressant ISP-1 as the sphingosine unit. Eur. J. Med. Chem. 2006. 41: 569-576.
12. Treiner, E. and Lantz, O., CD1d- and MR1-restricted invariant T cells: of mice and men. Curr. Opin. Immunol. 2006. 18: 519-526.
13. Shimamura, M., Huang, Y.-Y., Okamoto, N., Suzuki, N., Yasuoka, J., Morita, K., Nishiyama, A. et al., Modulation of Vα19 NKT cell immune responses by α-mannosyl ceramide derivatives consisting of a series of modified sphingosines. Eur. J. Immunol. 2007. 37: DOI10.1002/eji.200636689.