Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NFκB nuclear translocation

European Journal of Pharmacology

Volumn 653, Issue 1-3, 2011, Pages 8-15

  Kole, Labanyamoy ^a   Giri, Biplab ^b   Manna, Sunil Kumar ^c   Pal, Biswajit ^d   Ghosh, Sajalendu ^e  

^a SYNGENE INTERNATIONAL LTD   (India)

^b WEST BENGAL STATE UNIVERSITY   (India)

^c CENTRE FOR DNA FINGERPRINTING AND DIAGNOSTICS   (India)

^d CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^e Ranchi College   (India)

Author keywords

Anti inflammatory activity; Anti proliferative activity; Biochanin A; Inflammation; Proliferation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; BIOCHANIN A; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENISTEIN; HT29 CELLS; HUMANS; INFLAMMATION; MACROPHAGES; MACROPHAGES, PERITONEAL; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT;

EID: 78651505391     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.11.026     Document Type: Article

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