IFN-α suppresses activation of nuclear transcription factors NF-κB and activator protein 1 and potentiates TNF-induced apoptosis

Journal of Immunology

Volumn 165, Issue 9, 2000, Pages 4927-4934

  Manna, S K ^a   Mukhopadhyay, A ^a   Aggarwal, B B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CYTOTOXICITY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; TRANSCRIPTION INITIATION;

EID: 0034327721     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.9.4927     Document Type: Article

References (51)

1. The synergistic antiproliferative effect of γ-interferon and human lymphotoxin
2. Chemical and biological properties of human lymphotoxin
3. Recombinant human tumor necrosis factor-α: Effects on proliferation of normal and transformed cells in vitro
4. Interrelationship of human interferon-γ with lymphotoxin and monocyte cytotoxin
5. Activation of human polymorphonuclear neutrophil functions by interferon-γ and tumor necrosis factors
6. Tumor necrosis factors: Gene structure and biological activities
7. Modulation of the growth of transformed cells by human tumor necrosis factor-α and interferon-γ
8. Characterization of receptors for human tumor necrosis factor and their regulation by γ-interferon
9. Interferon-γ induces cell surface expression for both types of tumor necrosis factor receptors
10. Induction of receptors for tumor necrosis factor-γ by interferons is not a major mechanism for their synergistic cytotoxic response
11. 2: Role of protein kinase C
12. Apoptosis: Activate NF-κB or die?
13. Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
14. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
15. AP-1 function and regulation
16. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
17. JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?
18. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
19. Activation of NF-κB by RANK Requires TRAF6 and NF-κB-Inducing Kinase (NIK): Identification of a novel TRAF6 interaction motif
20. Overexpression of Mn-superoxide dismutase suppresses TNF-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1
21. Silymatin suppresses TNF-induced activation of nuclear transcription factor-κB, c-Jun N-terminal kinase and apoptosis
22. Hematopoietic progenitor kinase (HPK1) stress response signaling pathway activates IkB kinases (IKK-α/β) and IKK-β is a developmentally regulated protein kinase
23. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent NF-κB activation and gene expression
24. How cells respond to interferons
25. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
26. 2 in NF-κB activation by either cytokine in both primary and transformed endothelial cells
27. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
28. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
29. TNF-induced signaling in apoptosis
30. Overexpression of γ-glutamylcysteine synthetase abolishes tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activator protein-1
31. TNF-induced signaling in apoptosis
32. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: Mediation through both mitogen-activated protein kinase and NF-κB signaling pathways in macrophages
33. Superoxide attenuates macrophage apoptosis by NF-κB and AP-1 activation that promotes cyclooxygenase-2 expression
34. Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene
35. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells
36. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers
37. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)
38. Interferon inhibits prostaglandin biosynthesis in macrophages: Effects on arachidonic acid metabolism
39. Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite
40. Exogenous and endogenous type I interferons inhibit interferon-γ-induced nitric oxide production and nitric oxide synthase expression in murine peritoneal macrophages
41. Regulation of mRNA levels of TNF-α and the α-chain of the high-affinity receptor for IgE inmast cells by IFN-γ and α/β
42. Type I interferons (IFN-α and -β) suppress cytotoxin (tumor necrosis factor-α and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cell
43. Antileukemic effect of recombinant tumor necrosis factor α in vitro and its modulation by α and γ interferons
44. Antiproliferative and cytotoxic effects of single and combined treatment with tumor necrosis factor α and/or α interferon on a human renal cell carcinoma xenotransplanted into nu/nu mice: Cell kinetic studies
45. High-level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed- Sternberg cells
46. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
47. Constitutive activation of NF-κB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells: Autocrine role of TNF and reactive oxygen intermediates
48. Rel/NF-κB/IκB proteins and cancer
49. The interferon-inducible p202 protein as a modulator of transcription: Inhibition of NF-κB, c-Fos, and c-Jun activities
50. Innovative treatment programs against cancer. II. Nuclear factor-κB (NF-κB) as a molecular target
51. Efficient adenoviral infection with IκB α reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent