Infection of human T lymphoid cells by human herpesvirus 6 is blocked by two unrelated protein tyrosine kinase inhibitors, biochanin A and herbimycin

AIDS Research and Human Retroviruses

Volumn 12, Issue 17, 1996, Pages 1629-1634

  Cirone, M ^a   Zompetta, C ^a   Tarasi, D ^a   Frati, L ^a,b   Faggioni, A ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS NEUROMED   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHANIN A; HERBIMYCIN; PROTEIN TYROSINE KINASE;

ARTICLE; CONTROLLED STUDY; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERNALIZATION; LYMPHOID CELL; MOLECULAR INTERACTION; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS CELL INTERACTION; VIRUS INHIBITION;

EID: 0030457879     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1996.12.1629     Document Type: Article

References (18)

1. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, and Gallo RC: Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986;234:596-600.
2. Wyatt LS, Balachandran N, and Frenkel N: Variations in the replication and antigenic properties of human herpesvirus 6 strains. J Infect Dis 1990;162:852-857.
3. Ablashi DV, Balachandran N, Josephs SF, Hung CL, Krueger GRF, Kramarsky B, Salahuddin SZ, and Gallo RC: Genomic polymorphism, growth properties and immunologic variations in human herpesvirus 6 isolates. Virology 1991;184:545-552.
4. Aubin J, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M, Richard S, Huraux J, and Agut H: Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J Clin Microbiol 1991;29:367-372.
5. Lusso P, Markham PD, Tschachler E, Di Marco Veronese F, Salahuddin SZ, Ablashi DV, Pahova J, Krohn K, and Gallo RC: J Exp Med 1988;167:1659-1670.
6. Gompels UA, Nicholas J, Lawrence G, Jones M, Thomson BJ, Martin MED, Efstathiou S, Craxton M, and Macaulay HA: The DNA sequence of human herpesvirus 6: Structure, coding content and genome evolution. Virology 1995;1:29-51.
7. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, and Kurata T: Identificaion of human herpesvirus 6 as a causal agent for exanthem subitum. Lancet 1988;1:1065-1067.
8. Lusso P, and Gallo RC: Human herpesvirus 6 in AIDS. Immunol Today 1995;16:67-71.
9. Pellett PE, Black JB, and Yamamoto M: Human herpesvirus 6: The virus and the search for its role as a human pathogen. Adv Virus Res 1992;41:1-52.
10. Razzaque A: Oncogenic potential of human herpesvirus 6. Oncogene 1990;5:1365-1370.
11. Yadav M, Chandrashekran A, Vasudevan DM, and Ablashi DV: Frequent detection of human herpesvirus 6 in oral carcinoma. J Natl Cancer Inst 1994;86:1792-1794.
12. Chen M, Wang H, Woodworth CD, Lusso P, Berneman Z, Kingma D, Delgado G, and Di Paolo JA: Detection of human herpesvirus 6 and human papillomavirus 16 in cervical carcinoma. Am J Pathol 1994;145:1509-1516.
13. Cirone M, Zompetta C, Angeloni A, Ablashi DV, Salahuddin SZ, Pavan A, Torrisi MR, Frati L, and Faggioni A: Infection by human herpesvirus 6 (HHV-6) of human T lymphoid cells occurs through an endocytic pathway. AIDS Res Hum Retroviruses 1992;8:2031-2037.
14. Mustelin T and Burn P: Regulation of src family tyrosine kinases in lymphocytes. Trends Biochem Sci 1993;18:215-220.
15. Cohen DI, Tani Y, Tian H, Boone E, Samelson LE, and Clifford Lane H: Participation of tyrosine phosphorylation in the cytopathic effect of human immunodeficiency virus-1. Science 1992;256:542-545.
16. Yura Y, Yoshida H, and Sato M: Inhibition of herpes simplex replication by genistein, an inhibitor of protein-tyrosine kinase. Arch Virol 1993;132:451-461.
17. Foà-Tomasi L, Guerrini S, Huang T, and Campadelli-Fiume G: Characterization of human herpesvirus 6 (U1102) and (GS) gp 112 and identificaion of the Z29-specified homolog. Virology 1992;191:511-516.
18. Cirone M, Angeloni A, Barile G, Zompetta C, Venanzoni M, Torrisi MR, Frati L, and Faggioni A: Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors. Int J Cancer 1990;45:490-493.