Synthesis of N 2-Alkyl-8-oxo-7,8-dihydro-2′-deoxyguanosine derivatives and effects of these modifications on RNA duplex stability

Journal of Organic Chemistry

Volumn 76, Issue 2, 2011, Pages 720-723

  Kannan, Arunkumar ^a   Burrows, Cynthia J ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REDUCTIVE AMINATION; RNA DUPLEXES; RNA-PROTEIN INTERACTIONS; THERMAL STABILITY STUDIES;

BIOMOLECULES; RNA;

ALKYLATION;

3' O [(DIISOPROPYLAMINO) (2 CYANOETHOXY)PHOSPHINO] 5' O (4,4' DIMETHOXYTRITYL) N2 PROPYL 8 OXO 7,8 DIHYDRO 2' DEOXYGUANOSINE; 5' O 4,4' DIMETHOXYTRITYL N2 PROPYL 8 OXO 7,8 DIHYDRO 2' DEOXYGUANOSINE; DEOXYGUANOSINE DERIVATIVE; DNA; N2 ALKYL 8 OXO 7,8 DIHYDRO 2' DEOXYGUANOSINE DERIVATIVE; N2 PROPYL 8 OXO 7,8 DIHYDRO 2' DEOXYGUANOSINE; RNA; UNCLASSIFIED DRUG; ALKANE; DEOXYGUANOSINE; DRUG DERIVATIVE;

ARTICLE; RNA STABILITY; AMINATION; BASE MISPAIRING; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ALKANES; AMINATION; BASE PAIR MISMATCH; DEOXYGUANOSINE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; RNA; RNA STABILITY;

EID: 78651487657     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo102187y     Document Type: Article

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