Derivatives of oxoisoaporphine alkaloids: A novel class of selective acetylcholinesterase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 13, 2007, Pages 3765-3768

  Tang, Huang ^a   Ning, Fang Xian ^a   Wei, Yong Biao ^a   Huang, Shi Liang ^a   Huang, Zhi Shu ^a   Chan, Albert Sun Chi ^b   Gu, Lian Quan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Acetylcholinesterase inhibitors; Butyrylcholinesterase; Oxoisoaporphine alkaloids; Synthesis

Indexed keywords

ACETYLCHOLINESTERASE; ALKALOID DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; METHYL IODIDE;

ARTICLE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ALKALOIDS; BUTYRYLCHOLINESTERASE; CARBAMATES; CATIONS; CHEMISTRY, PHARMACEUTICAL; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34250165448     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.015     Document Type: Article

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