Hepatocyte targeting and intracellular copper chelation by a thiol-containing glycocyclopeptide

Journal of the American Chemical Society

Volumn 133, Issue 2, 2011, Pages 286-296

  Pujol, Anaïs M ^a   Cuillel, Martine ^b   Renaudet, Olivier ^c   Lebrun, Colette ^a   Charbonnier, Peggy ^b   Cassio, Doris ^d   Gateau, Christelle ^a   Dumy, Pascal ^c   Mintz, Elisabeth ^b   Delangle, Pascale ^a  

^a CNRS   (France)

^b UNIV GRENOBLE ALPES   (France)

^c UNIVERSITÉ JOSEPH FOURIER   (France)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTORS; CARBOHYDRATE RECOGNITION ELEMENTS; CELLULAR UPTAKE; CHELATING UNITS; COPPER CHELATIONS; COPPER CONCENTRATION; DISULFIDE BRIDGE; GENETIC DISORDERS; GLUTATHIONES; GLYCOPEPTIDES; HEPATIC CELLS; HEPATOCYTES; HIGH AFFINITY; HIGH SELECTIVITY; IN-CELL; METAL ION COMPLEXATION; REDUCING ENVIRONMENT; SIDE CHAINS; THIOL FUNCTIONS; THIOLATES; WILSON'S DISEASE;

AMINO ACIDS; CARBOHYDRATES; CELL CULTURE; COPPER; FACE RECOGNITION; IODINE; LIVER; METAL IONS; SYNTHESIS (CHEMICAL); ZINC COMPOUNDS;

CHELATION;

ASIALOGLYCOPROTEIN RECEPTOR; CADMIUM; CHELATING AGENT; COPPER; CYCLOPEPTIDE; CYSTEINE; DISULFIDE; GLUTATHIONE; GLYCOPEPTIDE; LEAD; MERCURY; THIOL DERIVATIVE; ZINC;

ARTICLE; BINDING AFFINITY; CELL SURFACE; CHELATION THERAPY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BINDING; DRUG CONFORMATION; DRUG OXIDATION; DRUG SELECTIVITY; DRUG UPTAKE; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LIVER CELL; METAL BINDING; PROTEIN EXPRESSION; TARGET CELL;

CELLS, CULTURED; CHELATING AGENTS; COPPER; HEP G2 CELLS; HEPATOCYTES; HUMANS; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; SULFHYDRYL COMPOUNDS;

EID: 78651398830     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja106206z     Document Type: Article

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