Metallochaperones and metal-transporting ATPases: A comparative analysis of sequences and structures

Genome Research

Volumn 12, Issue 2, 2002, Pages 255-271

  Arnesano, Fabio ^a   Banci, Lucia ^a   Bertini, Ivano ^a   Ciofi Baffoni, Simone ^a   Molteni, Elena ^a   Huffman, David L ^b   O'Halloran, Thomas V ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; CHAPERONE; COPPER; METAL; ZINC;

ACTIVE TRANSPORT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MEMBRANE BINDING; METAL BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN MOTIF; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STATISTICAL ANALYSIS; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; VALIDATION PROCESS; YEAST;

ADENOSINE TRIPHOSPHATASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; HYDROPHOBICITY; METALS, HEAVY; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036175362     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.196802     Document Type: Article

References (88)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. Characterization of the binding interface between the copper chaperone Atx1 and the first cytosolic domain of Ccc2 ATPase
3. Solution structure of the Cu(I) and Apo forms of the yeast metallochaperone, Atx1
4. Evolution of substrate specificities in the P-type ATPase superfamily
5. Neutral networks in protein space: A computational study based on knowledge-based potentials of mean force
6. Copper trafficking: The solution structure of Bacillus subtilis CopZ
7. Solution structure of the yeast copper transporter domain Ccc2a in the apo and Cu(I)-loaded states
8. Wilson disease and Menkes disease: New handles on heavy-metal transport
9. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
10. Identification of Sinorhizobium meliloti genes regulated during symbiosis
11. Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein
12. The Enterococcus hirae copper chaperone CopZ delivers copper(I) to the CopY repressor
13. Stoichiometry of complex formation between Copper(I) and the N-terminal domain of the Menkes protein
14. Advanced Inorganic Chemistry
15. The copper chaperone for superoxide dismutase
16. Genes involved in the formation and assembly of rhizobial cytochromes and their role in symbiotic nitrogen fixation
17. The genetics and biochemistry of mercury resistance
18. Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily
19. Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase
20. Molecular basis for resistance to silver cations in Salmonella
21. Correlation between stability of a protein and its dipeptide composition: A novel approach for predicting in vivo stability of a protein from its primary sequence
22. Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis
23. A structural classification of proteins database
24. Energetics of copper trafficking between the Atx1 metallochaperone and the intracellular copper-transporter, Ccc2
25. Function, structure, and mechanism of intracellular copper trafficking proteins
26. HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense
27. Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis
28. MOLMOL: A program for display and analysis of macromolecular structure
29. Crystal structure of the copper chaperone for superoxide dismutase
30. Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p
31. PROCHECK: A program to check the stereochemical quality of protein structures
32. The quality of merC, a module of the mer mosaic
33. The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity
34. Biochemistry of Copper
35. Identification of the copper chaperone SAH in Ovis aries: Expression analysis and in vitro interaction of SAH with ATP7B
36. Cloning, mapping and expression analysis of the sheep Wilson disease gene homologue
37. Role of the merT and merP gene products of transposon Tn501 in the induction and expression of resistance to mercuric ions
38. N-terminal domains of human copper-transporting adenosine triphosphatases (the Wilson's and Menkes disease proteins) bind copper selectively in vivo and in vitro with stoichiometry of one copper per metal-binding repeat
39. Properties and function of the P type ion pumps cloned from Helicobacter pylori
40. Isolation of a partial candidate gene for Menkes disease by positional cloning
41. Bacterial detoxification of Hg(II) and organomercurials
42. Bradyrhizobium japonicum FixK2, a crucial distributor in the FixLJ-dependent regulatory cascade for control of genes inducible by low oxygen levels
43. Expression of copper trafficking genes in the mouse brain
44. An analysis of incorrectly folded protein models: Implications for structural predictions
45. Criteria that discriminate between native proteins and incorrectly folded models
46. Cadmium resistance from Staphylococcus aureus plasmid pI258 cadA gene results from a cadmium-efflux ATPase
47. Transition metals in control of gene expression
48. Metallochaperones: An intracellular shuttle service for metal ions
49. Two trans-acting metalloregulatory proteins controlling expression of the copper-ATPases of Enterococcus hirae
50. An ATPase operon involved in copper resistance by Enterococcus hirae
51. Primary structure of two P-type ATPase involved in copper homeostasis in Enterococcus hirae
52. Protein superfamilies and domain superfolds
53. A delicate balance: Homeostatic control of copper uptake and distribution
54. P-type ATPase from the cyanobacterium Synechococcus 7942 related to the human Menkes and Wilson disease gene products
55. Structure-function analyses of the ATX1 metallochaperone
56. Metal ion chaperone function of the soluble Cu(I) receptor Atx1
57. Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase
58. CopA: An Escherichia coli Cu(I)-translocating P-type ATPase
59. Families of soft-metal-ion-transporting ATPases
60. The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase
61. Pb(II)-translocating P-type ATPases
62. Sequence and structure conservation in a protein core
63. The role of efflux in bacterial resistance to soft metals and metalloids
64. Copper delivery by metallochaperone proteins
65. Crystal structure of the Atx1 metallochaperone protein at 1.02 A resolution
66. Prediction of protein secondary structure at better than 70% accuracy
67. Combining evolutionary information and neural networks to predict protein secondary structure
68. Cobalt-dependent transcriptional switching by a dual-effector MerR-like protein regulates a cobalt-exporting variant CPx-type ATPase
69. Purification and properties of the mercuric-ion-binding protein MerP
70. Modeling mutations and homologous proteins
71. Comparative protein modelling by satisfaction of spatial restraints
72. Newer systems for bacterial resistances to toxic heavy metals
73. Bacterial resistance ATPases: Primary pumps for exporting toxic cations and anions
74. Recognition of errors in the three-dimensional structures
75. CPx-type ATPases: A class of P-type ATPases that pump heavy metals
76. Structures of the reduced and mercury-bound forms of MerP, the periplasmic protein from the bacterial mercury detoxification system
77. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene
78. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
79. The structure of the metal-binding motif GMTCAAC is similar in an 18-residue linear peptide and in the mercury binding protein MerP
80. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase
81. Cellular copper transport
82. Identification of the copper chaperone, CUC-1, in Caenorhabditis elegans: Tissue specific co-expression with the copper transporting ATPase, CUA-1
83. Structural basis for metal ion transfer by the copper chaperone for the Menkes and Wilson disease proteins
84. NMR structure and metal interactions of the CopZ copper chaperone
85. Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease
86. Biochemical characterization and intracellular localization of the Menkes disease protein
87. Restriction of copper export in Saccharomyces cerevisiae to a late Golgi or post-Golgi compartment in the secretory pathway
88. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake