Release of bioactive BMP from dextran-derived microspheres: A novel delivery concept

International Journal of Pharmaceutics

Volumn 307, Issue 1, 2006, Pages 23-32

  Chen, Fa Ming ^a,c   Wu, Zhi Fen ^a   Sun, Hai Hua ^b   Wu, Hong ^a   Xin, Su Ning ^c   Wang, Qin Tao ^a   Dong, Guang Ying ^a   Ma, Zhi Wei ^a   Huang, Sha ^a   Zhang, Yong Jie ^a   Jin, Yan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b The Second Qingdao sanatorium of CPLA   (China)

^c Hospital of CPLA   (China)

Author keywords

Bone morphogenetic proteins; Drug delivery system; Functionalized dextran; In vitro release; Microspheres; Periodontal ligament cells; Poly(ethylene glycol)

Indexed keywords

DEXTRAN 70; GLYCIDYLMETHACRYLATE; MACROGOL; METHACRYLIC ACID DERIVATIVE; MICROSPHERE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOLOGY; DRUG ACTIVITY; DRUG DEGRADATION; DRUG DESIGN; DRUG EFFECT; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; PERIODONTAL LIGAMENT; POLYMERIZATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUBSTITUTION REACTION;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; CELLS, CULTURED; DEXTRANS; DRUG CARRIERS; DRUG COMPOUNDING; EPOXY COMPOUNDS; HUMANS; METHACRYLATES; MICROSPHERES; OSTEOBLASTS; OSTEOPONTIN; PERIODONTAL LIGAMENT; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; SIALOGLYCOPROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 28844475647     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.09.024     Document Type: Article

References (48)

1. S.P. Baldwin, and W.M. Saltzman Materials for protein delivery in tissue engineering Adv. Drug Deliv. Rev. 33 1998 71 86
2. S.D. Boden, J. Kang, H. Sandhu, and J.G. Heller Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies Spine 27 2002 2662 2673
3. L. Brannon-Peppas Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery Int. J. Pharm. 116 1995 1 9
4. J.K. Burkus, S.E. Heim, M.F. Gornet, and T.A. Zdeblick Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device J. Spinal. Disord. Tech. 16 2003 113 122
5. J.K. Burkus, S.E. Heim, M.F. Gornet, and T.A. Zdeblick The effectiveness of rhBMP-2 in replacing autograft: an integrated analysis of three human spine studies Orthopedics 27 2004 723 728
6. F.M. Chen, Z.F. Wu, Q.T. Wang, H. Wu, Y.J. Zhang, X. Nie, and Y. Jin Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics Acta Pharmacol. Sin. 26 2005 1089 1099
7. F.M. Chen, Z.F. Wu, Q.T. Wang, H. Wu, Y.J. Zhang, X. Nie, and Y. Jin Preparation and biological characteristics of recombinant human bone morphogenetic protein-2-loaded dextran-co-gelatin hydrogel microspheres, in vitro and in vivo studies Pharmacology 75 2005 133 144
8. C.M. Cowan, O.O. Aalami, Y.Y. Shi, Y.F. Chou, C. Mari, R. Thomas, N. Quarto, R.P. Nacamuli, C.H. Contag, B. Wu, and M.T. Longaker Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation, osteoclast recruitment, and bone turnover Tissue Eng. 11 2005 645 658
9. D.J.A. Crommelin, and R.D. Sindelar Pharmaceutical Biotechnology 1997 Harwood Academic Publishers London
10. I.M. Driesang, and E.B. Hunziker Delamination rates of tissue flaps used in articular cartilage repair J. Orthop. Res. 18 2000 909 911
11. L. Ferreira, M.H. Gil, A.M. Cabrita, and J.S. Dordick Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels Biomaterials 26 2005 4707 4716
12. O. Franssen, L. Vandervennet, P. Roders, and W.E. Hennink Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres J. Cont. Rel. 60 1999 211 221
13. S. Freiberg, and X.X. Zhu Polymer microspheres for controlled drug release Int. J. Pharm. 282 2004 1 18
14. M. Geiger,.R.H. Li, and W. Friess Collagen sponges for bone regeneration with rhBMP-2 Adv. Drug Deliv. Rev. 55 2003 1613 1629
15. W.R. Gombotz, and D.K. Pettit Biodegradable polymers for protein and peptide drug delivery Bioconj. Chem. 6 1995 332 351
16. L.L. Hench, I.D. Xynos, and J.M. Polak Bioactive glasses for in situ tissue regeneration J. Biomater. Sci. Polym. Ed. 15 2004 543 562
17. T.A. Holland, J.K. Tessmar, Y. Tabata, and A.G. Mikos Transforming growth factor-beta 1 release from oligo(poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment J. Contr. Rel. 94 2004 101 114
18. E.B. Hunziker, I.M. Driesang, and C. Saager Structural barrier principle for growth factor-based articular cartilage repair Clin. Orthop. Relat. Res. 391 2001 S182 S189 Suppl
19. E.B. Hunziker, and I.M. Driesang Functional barrier principle for growth-factor-based articular cartilage repair Osteoarthr. Cartilage 11 2003 320 327
20. C.S. Kim, J.I. Kim, J. Kim, S.H. Choi, J.K. Chai, C.K. Kim, and K.S. Cho Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers Biomaterials 26 2005 2501 2507
21. S.H. Kim, C.Y. Won, and C.C. Chu Synthesis and characterization of dextran-maleic acid based hydrogel J. Biomed. Mater. Res. 46 1999 160 170
22. S.H. Kim, and C.C. Chu Synthesis and characterization of dextran-methacrylate hydrogels and structural study by SEM J. Biomed. Mater. Res. 49 2000 517 527
23. G.N. King, and F.J. Hughes Bone morphogenetic protein-2 stimulates cell recruitment and cementogenesis during early wound healing J. Clin. Periodontol. 28 2001 465 475
24. G.N. King The importance of drug delivery to optimize the effects of bone morphogenetic proteins during periodontal regeneration Curr. Pharm. Biotechnol. 2 2001 131 142
25. M. Kobayashi, T. Takiguchi, R. Suzuki, A. Yamaguchi, K. Deguchi, M. Shionome, Y. Miyazawa, T. Nishihara, M. Nagumo, and K. Hasegawa Recombinant human bone morphogenetic protein-2 stimulates osteoblastic differentiation in cells isolated from human periodontal ligament J. Dent. Res. 78 1999 1624 1633
26. C.H. Lee, A. Singla, and Y. Lee Biomedical applications of collagen Int. J. Pharm. 221 2001 1 22
27. J. Li, S.T. Yoon, and W.C. Hutton Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells J. Spinal. Disord. Tech. 17 2004 423 438
28. H. Maeda, A. Sano, and K. Fujioka Controlled release of rhBMP-2 from collagen minipellet and the relationship between release profile and ectopic bone formation Int. J. Pharm. 275 2004 109 122
29. M. Maire, D. Logeart-Avramoglou, M.C. Degat, and F. Chaubet Retention of transforming growth factor beta1 using functionalized dextran-based hydrogels Biomaterials 26 2005 1771 1780
30. M.C. Manning, K. Patel, and R.T. Borchardt Stability of protein pharmaceuticals Pharm. Res. 6 1989 903 918
31. M. Marion, C. Frederic, M. Pierrer, B. Cinderella, M. Alain, and L.A. Delphine Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels Biomaterials 26 2005 5085 5092
32. C.E. Markopoulou, I.A. Vrotsos, H.N. Vavouraki, X.E. Dereka, and Z.S. Mantzavinos Human periodontal ligament cell responses to recombinant human bone morphogenetic protein-2 with and without bone allografts J. Periodontol. 74 2003 982 989
33. D.A. Miranda, N.M. Blumenthal, R.G. Sorensen, J.M. Wozney, and U.M. Wikesjo Evaluation of recombinant human bone morphogenetic protein-2 on the repair of alveolar ridge defects in baboons J. Periodontol. 76 2005 210 220
34. T. Niwa, H. Takeuchi, T. Hino, N. Kunou, and Y. Kawashima In vitro drug release behavior of d,l-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method J. Pharm. Sci. 83 1994 727 732
35. S. Pitaru, A. Pritzki, I. Bar-Kana, A. Grosskopf, N. Savion, and A.S. Narayanan Bone morphogenetic protein 2 induces the expression of cementum attachment protein in human periodontal ligament clones Connect. Tissue Res. 43 2002 257 264
36. H.G. Schmokel, F.E. Weber, G. Seiler, B. von Rechenberg, J.C. Schense, P. Schawalder, and J. Hubbell Treatment of nonunions with nonglycosylated recombinant human bone morphogenetic protein-2 delivered from a fibrin matrix Vet. Surg. 33 2004 112 118
37. X. Si, and Z. Liu The biological effects of recombinant human bone morphogenetic protein 2 on human periodontal ligament fibroblasts Hua Xi Kou Qiang Yi Xue Za Zhi 20 2002 10 13
38. K.A. Selvig, R.G. Sorensen, J.M. Wozney, and U.M. Wikesjo Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration J. Periodontol. 73 2002 1020 1029
39. A. Singla, and C.H. Lee Effect of elastin on the calcification rate of collagen-elastin matrix systems J. Biomed. Mater. Res. 60 2002 368 374
40. M.J. Somerman, R.A. Foster, G.M. Vorsteg, K. Progebin, and R.L. Wynn Effects of minocycline on fibroblast attachment and spreading J. Periodontal. Res. 23 1988 154 159
41. R.J. Stenekes, O. Franssen, E.M. van Bommel, D.J. Crommelin, and W.E. Hennink The preparation of dextran microspheres in an all-aqueous system: effect of the formulation parameters on particle characteristics Pharm. Res. 15 1998 557 561
42. R.J. Stenekes, O. Franssen, E.M. van Bommel, D.J. Crommelin, and W.E. Hennink The use of aqueous PEG/dextran phase separation for the preparation of dextran microspheres Int. J. Pharm. 183 1999 29 32
43. R.J. Stenekes, A.E. Loebis, C.M. Fernandes, D.J. Crommelin, and W.E. Hennink Controlled release of liposomes from biodegradable dextran microspheres: a novel delivery concept Pharm. Res. 17 2000 690 695
44. R.J. Stenekes, A.E. Loebis, C.M. Fernandes, D.J. Crommelin, and W.E. Hennink Degradable dextran microspheres for the controlled release of liposomes Int. J. Pharm. 214 2001 17 20
45. D. Takahashi, T. Odajima, M. Morita, M. Kawanami, and H. Kato Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats J. Periodontal. Res. 40 2005 299 305
46. E. Vogelin, N.F. Jones, J.I. Huang, J.H. Brekke, and J.R. Lieberman Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein J. Bone Joint Surg. Am. 87 2005 1323 1331
47. S.H. Wang, L.C. Zhang, F. Lin, X.Y. Sa, J.B. Zuo, Q.X. Shao, G.S. Chen, and S. Zeng Controlled release of levonorgestrel from biodegradable poly(d,l-lactide-co-glycolide) microspheres: in vitro and in vivo studies Int. J. Pharm. 301 2005 217 225
48. U.M. Wikesjo, G. Polimeni, and M. Qahash Tissue engineering with recombinant human bone morphogenetic protein-2 for alveolar augmentation and oral implant osseointegration: experimental observations and clinical perspectives Clin. Implant. Dent. Relat. Res. 7 2005 112 119