Effect of surgical implantation of recombinant human bone morphogenetic protein-2 in a bioabsorbable collagen sponge or calcium phosphate putty carrier in intrabony periodontal defects in the baboon

Journal of Periodontology

Volumn 73, Issue 12, 2002, Pages 1494-1506

  Blumenthal, Neil M ^a   Koh Kunst, Grace ^a   Alves, Mario E A F ^a   Miranda, Dario ^a   Sorensen, Rachel G ^b   Wozney, John M ^b   Wikesjö, Ulf M E ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b PFIZER INC   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal studies; Bone regeneration; Dental cementum growth and development; Periodontal attachment; Periodontal regeneration; Proteins, bone morphogenetic; Wound healing

Indexed keywords

CALCIUM PHOSPHATE; COLLAGEN; DRUG CARRIER; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ALVEOLAR BONE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKYLOSIS; ARTICLE; BABOON; BIOSORPTION; BIOTECHNOLOGY; BONE DEFECT; BONE REGENERATION; CELL MIGRATION; CEMENTUM; CONNECTIVE TISSUE; CONTROLLED STUDY; EPITHELIUM CELL; HISTOMETRY; IMPLANTATION; MANDIBLE; MAXILLA; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; RANDOMIZATION; TOOTH ROOT;

ALVEOLAR BONE LOSS; ANALYSIS OF VARIANCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; CALCIUM PHOSPHATES; CEMENTOGENESIS; COLLAGEN; DRUG CARRIERS; DRUG IMPLANTS; HUMANS; ORAL SURGICAL PROCEDURES; PAPIO; PERIODONTAL LIGAMENT; POSTOPERATIVE CARE; RECOMBINANT PROTEINS; REGENERATION; ROOT RESORPTION; TOOTH ANKYLOSIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036960246     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2002.73.12.1494     Document Type: Article

References (66)

1. Hogan BLM. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes Dev 1996;10:1580-1594.
2. Urist MR. Bone: Formation by autoinduction. Science 1965;150:893-899.
3. Celeste AJ, Iannazzi JA, Taylor RC, et al. Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci (USA) 1990;87:9843-9847.
4. Özkaynak E, Rueger DC, Drier EA, et al. OP-1 cDNA encodes an osteogenic protein in the TGF-β family. EMBO J 1990;9:2085-2093.
5. Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988;242:1528-1534.
6. Wang EA, Rosen V, D'Alessandro JS, et al. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci (USA) 1990;87:2220-2224.
7. Toriumi DM, Kotler HS, Luxenberg DP, Holtrop ME, Wang EA. Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation. Arch Otolaryngol Head Neck Surg 1991; 117:1101-1112.
8. Boyne PJ. Animal studies of the application of rhBMP-2 in maxillofacial reconstruction. Bone 1996;19:83S-92S.
9. Toriumi DM, O'Grady K, Horlbeck DM, Desai D, Turek TJ, Wozney J. Mandibular reconstruction using bone morphogenetic protein 2: Long-term follow-up in a canine model. Laryngoscope 1999;109:1481-1489.
10. Boyne PJ, Nakamura A, Shabahang S. Evaluation of the long-term effect of function on rhBMP-2 regenerated hemimandibulectomy defects. Br J Oral Maxillofac Surg 1999;37:344-352.
11. Mayer M, Hollinger J, Ron E, Wozney J. Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier. Plast Reconstr Surg 1996;98:247-259.
12. Boyne PJ, Nath R, Nakamura A. Human recombinant BMP-2 in osseous reconstruction of simulated cleft palate defects. Br J Oral Maxillofac Surg 1998;36:84-90.
13. Yudell RM, Block MS. Bone gap healing in the dog using recombinant human bone morphogenetic protein-2. J Oral Maxillofac Surg 2000;58:761-766.
14. Sigurdsson TJ, Fu E, Tatakis DN, Rohrer MD, Wikesjö UME. Bone morphogenetic protein-2 enhances peri-implant bone regeneration and osseointegration. Clin Oral Implants Res 1997;8:367-374.
15. Hanisch O, Tatakis DN, Boskovic MM, Rohrer MD, Wikesjö UME. Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2. Int J Oral Maxillofac Implants 1997;12: 604-610.
16. Cochran DL, Nummikoski PV, Jones AA, Makins SR, Turek TJ, Buser D. Radiographic analysis of regenerated bone around endosseous implants in the canine using recombinant human bone morphogenetic protein-2. Int J Oral Maxillofac Implants 1997;12:739-748.
17. Steinberg B, Chiego DJ Jr, Huizinga PJ, Wozney JM, Wikesjö UME. Effect of human bone morphogenetic protein 2 implant on tooth eruption in an experimental design. J Craniofac Surg 1999;10:338-341.
18. Cochran DL, Schenk R, Buser D, Wozney JM, Jones AA. Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. J Periodontol 1999;70:139-151.
19. Barboza EP, Duarte MEL, Geolás L, Sorensen RG, Riedel GE, Wikesjö UME. Ridge augmentation following implantation of recombinant human bone morphogenetic protein-2 in the dog. J Periodontol 2000;71:488-496.
20. Sigurdsson TJ, Nguyen S, Wikesjö UME. Alveolar ridge augmentation with rhBMP-2 and bone-to implant contact in induced bone. Int J Periodontics Restorative Dent 2001;21:461-473.
21. Hunt DR, Jovanovic SA, Wikesjö UME, Wozney JM, Bernard GW. Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. A pilot study. J Periodontol 2001;72:651-658.
22. Boyne PJ, Shabahang S. An evaluation of bone induction delivery materials in conjunction with root-form implant placement. Int J Periodontics Restorative Dent 2001;21:333-343.
23. Tatakis DN, Koh A, Jin L, Wozney JM, Rohrer MD, Wikesjö UME. Peri-implant bone regeneration using rhBMP-2/ACS in a canine model: A dose-response study. J Periodont Res 2002;37:93-100.
24. Hanisch O, Sorensen RG, Kinoshita A, Spiekermann H, Wozney JM, Wikesjö UME. Effect of rhBMP-2/ACS in dehiscence defects with non-submerged immediate implants: An experimental study. J Periodontol 2002; accepted for publication.
25. Jovanovic SA, Hunt DR, Bernard GW, Spiekermann H, Wozney JM, Wikesjö UME. Bone reconstruction following implantation of rhBMP-2 with guided bone regeneration membranes in canine alveolar ridge defects. Clin Oral Implants Res 2002; accepted for publication.
26. Jovanovic SA, Hunt DR, Bernard GW, Spiekermann H, Wozney JM, Wikesjö UME. Long-term functional loading of dental implants in rhBMP-2 induced bone. A histologic study in the canine ridge augmentation model. Clin Oral Implants Res 2002; accepted for publication.
27. Nevins M, Kirker-Head C, Nevins M, Wozney JA, Palmer R, Graham D. Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. Int J Periodontics Restorative Dent 1996;16:8-19.
28. Kirker-Head CA, Nevins M, Palmer R, Nevins ML, Schelling SH. A new animal model for maxillary sinus floor augmentation: Evaluation parameters. Int J Oral Maxillofac Implants 1997;12:403-411.
29. Hanisch O, Tatakis DN, Rohrer MD, Wöhrle PS, JM Wozney, Wikesjö UME. Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates. Int J Oral Maxillofac Implants 1997;12:785-792.
30. Sykaras N, Triplett RG, Nunn ME, Iacopino AM, Opperman LA. Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants. Clin Oral Implants Res 2001; 12:339-349.
31. Ishikawa I, Kinoshita A, Oda S, Roongruangphol T. Regenerative therapy in periodontal diseases. Histological observations after implantation of rhBMP-2 in the surgically created periodontal defects in adults dogs. Dent Japan 1994;31:141-146.
32. Sigurdsson TJ, Lee MB, Kubota K, Turek TJ, Wozney JM, Wikesjö UME. Periodontal repair in dogs: Recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J Periodontol 1995; 66:131-138.
33. Sigurdsson TJ, Tatakis DN, Lee MB, Wikesjö UME. Periodontal regenerative potential of space providing expanded polytetrafluoroethylene membranes and recombinant human bone morphogenetic proteins. J Periodontol 1995; 66:511-521.
34. Sigurdsson TJ, Nygaard L, Tatakis DN, et al. Periodontal repair in dogs: Evaluation of rhBMP-2 carriers. Int J Periodontics Restorative Dent 1996;16:525-537.
35. Kinoshita A, Oda S, Takahashi K, Yokota S, Ishikawa I. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs. J Periodontol 1997;68:103-109.
36. Wikesjö UME, Guglielmoni PG, Promsudthi A, et al. Periodontal repair in dogs: Effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment. J Clin Periodontol 1999;26:392-400.
37. Choi S-H, Kim C-K, Cho K-S, et al. Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol 2002;73:63-72.
38. Selvig KA, Sorensen RG, Wozney JM, Wikesjö UME. Ultrastructure of tissue repair following rhBMP-2 stimulated periodontal regeneration. J Periodontol 2002;73: 1020-1029.
39. Wikesjö UME, Lim WH, Thomson RC, Cook AD, Wozney JM, Hardwick WR. Periodontal repair in dogs: Evaluation of a bioresorbable space-providing macro-porous membrane with rhBMP-2. J Periodontol 2002; accepted for publication.
40. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 1997;17:11-25.
41. Howell TH, Fiorellini J, Jones A, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. Int J Periodontics Restorative Dent 1997;17: 125-139.
42. Ripamonti U, Heliotis M, Rueger DC, Sampath TK. Induction of cementogenesis by recombinant human osteogenic protein-1 (hop-1/bmp-7) in the baboon (Papio ursinus). Short communication. Arch Oral Biol 1996; 41:121-126.
43. Giannobile WV, Ryan S, Shih M-S, Su DL, Kaplan PL, Chan TCK. Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in Class III furcation defects. J Periodontol 1998;69:129-137.
44. Knaack D, Goad MEP, Aiolova M, et al. Resorbable calcium phosphate bone substitute. J Biomed Mater Res 1998;43:399-409.
45. Ishikawa K, Miyamoto Y, Takechi M, et al. Non-decay type fast-setting calcium phosphate cement: Hydroxyapatite putty containing an increased amount of sodium alginate. J Biomed Mater Res 1997;36:393-399.
46. Burr DB, Mori S, Boyd R, et al. Histomorphometric assessment of the mechanisms for rapid ingrowth of bone to HA/TCP coated implants. J Biomed Mat Res 1993;27:645-653.
47. Gottlander M, Johansson C, Wennerberg A, Albrektsson T, Radin S, Ducheyne P. Bone tissue reactions to an electrophoretically applied calcium phosphate coating. Biomaterials 1997;18:551-557.
48. Oda S, Kinoshita A, Higuchi T, Shizuya T, Ishikawa I. Ectopic bone induction in recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with biphasic calcium phosphate (in Japanese). Kokubyo Gakkai Zasshi 1996;63:468-477.
49. Luna LG. Histologic Methods and Color Atlas of Special Stains and Tissue Artifacts. New York: American Histolab, Inc., Publications Division;1992:113.
50. Schenk RK, Olah AJ, Herrmann W. Preparation of calcified tissues for light microscopy. In: Dickson GR, ed. Methods of Calcified Tissue Preparation. Copenhagen: Elsevier Science Publishers BV;1984:1-42.
51. Avery BE, Simpson DM. The baboon as a model system for the study of periodontal disease: Clinical and light microscopic observations. J Periodontol 1973;44: 675-686.
52. Virgadamo P, Hodosh M, Povar M, Shklar G. The dentition of Papio anubis. J Dent Res 1972;51:1338-1345.
53. Caton J, Mota L, Gandini L, Laskaris B. Non-human primate models for testing the efficacy and safety of periodontal regeneration procedures. J Periodontol 1994;65: 1169-1172.
54. Gottlow J, Karring T, Nyman S. Guided tissue regeneration following treatment of recession-type defects in the monkey. J Periodontol 1990;61:680-685.
55. Blumenthal NM, Alves ME. The use of demineralized freeze-dried bone-glycoprotein matrix grafts in treating baboon periodontal infrabony defects. Int J Periodontics Restorative Dent 2000;20:61-69.
56. Ripamonti U, Heliotis M, van den Heever B, Reddi AH. Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus). Brief communication. J Periodont Res 1994;29:439-445.
57. Haney JM, Zimmerman GJ, Wikesjö UME. Periodontal repair in dogs: Evaluation of the natural disease model. J Clin Periodontol 1995;22:208-213.
58. Jones WA, O'Leary TJ. The effectiveness of in vivo root planing in removing bacterial endotoxin from the roots of periodontally involved teeth. J Periodontol 1978;49: 337-342.
59. Kuboki Y, Sasaki M, Saito A, Takita H, Kato H. Regeneration of periodontal ligament and cementum by BMP-applied tissue engineering. Eur J Oral Sci 1998;106 (Suppl. 1):197-203.
60. Kim C-K, Kim H-Y, Chai J-K, et al. Effect of a calcium sulfate implant with calcium sulfate barrier on periodontal healing in 3-wall intrabony defects in dogs. J Periodontol 1998;69:982-988.
61. Blumenthal N, Sabe T, Barrington E. Healing responses to grafting of combined collagen-decalcified bone in periodontal defects in dogs. J Periodontol 1986;57:84-90.
62. Muschler GF, Hyodo A, Manning T, Kambic H, Easley K. Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model. Clin Orthop 1994; 308:229-240.
63. Gerhart TN, Kirker-Head CA, Kriz MJ, et al. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop 1993; 293:317-326.
64. Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg Am 1992; 74:659-670.
65. Kenley R, Marden L, Turek T, Jin L, Ron E, Hollinger JO. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2). J Biomed Mater Res 1994;28:1139-1147.
66. Kobayashi M, Takiguchi T, Suzuki R, et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic differentiation in cells isolated from human periodontal ligament. J Dent Res 1999;78:1624-1633.