Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model

Bone

Volumn 43, Issue 5, 2008, Pages 931-940

  Patel, Zarana S ^a   Young, Simon ^a   Tabata, Yasuhiko ^b   Jansen, John A ^c   Wong, Mark E K ^d   Mikos, Antonios G ^a  

^a Rice University   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

BLANK; BMP 2; Bone morphogenetic protein 2; bone morphogenetic protein 2, and also implant group containing this growth factor within the scaffold; Bone tissue engineering; Controlled release; critical size defect; CSD; DUAL; EMPTY; Gelatin microparticles; group which had no scaffold implanted within the defect; implant group containing both VEGF and BMP 2 within the scaffold; implant group containing no growth factor within the scaffold; microcomputed tomography; microCT; PBS; phosphate buffered saline; poly(propylene fumarate); PPF; Vascular endothelial growth factor; vascular endothelial growth factor, and also implant group containing this growth factor within the scaffold; VEGF; VOI; volume of interest

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; GELATIN; POLYMER; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REGENERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HISTOLOGY; IMPLANT; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; RAT; SKULL; SKULL DEFECT; TISSUE ENGINEERING;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; DRUG DELIVERY SYSTEMS; GELATIN; IMPLANTS, EXPERIMENTAL; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; PARTICLE SIZE; RATS; RATS, INBRED F344; REGENERATION; SKULL; TISSUE SCAFFOLDS; TOMOGRAPHY, X-RAY COMPUTED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 51449094036     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.06.019     Document Type: Article

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