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Volumn 14, Issue 4, 2008, Pages 341-366

Strategies and applications for incorporating physical and chemical signal gradients in tissue engineering

Author keywords

[No Author keywords available]

Indexed keywords

BIO-MIMETIC; BIOMATERIAL DESIGNS; CELL ADHESION MOLECULES; CHEMICAL SIGNALS; CONCENTRATION GRADIENTS; CONTINUOUS TRANSITIONS; EMBRYONIC DEVELOPMENTS; EMERGING TRENDS; ENGINEERING DESIGNS; EXTRACELLULAR; GROWTH FACTORS; HETEROGENEOUS TISSUES; HIGH-THROUGHPUT SCREENINGS; IMPLANT DESIGNS; IN-VIVO; MECHANICAL INTEGRITIES; SIGNALING MOLECULES; THREE DIMENSIONS; TISSUE ENGINEERING APPLICATIONS; TISSUE ENGINEERS; TISSUE FORMATIONS; TISSUE INTERFACES; TISSUE REGENERATIONS; TWO DIMENSIONS; WOUND REPAIRS;

EID: 56749184061     PISSN: 19373368     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.teb.2008.0304     Document Type: Review
Times cited : (175)

References (186)
  • 1
    • 0035968012 scopus 로고    scopus 로고
    • Graded materials for resistance to contact deformation and damage
    • Suresh, S. Graded materials for resistance to contact deformation and damage. Science 292, 2447, 2001.
    • (2001) Science , vol.292 , pp. 2447
    • Suresh, S.1
  • 2
    • 41349123502 scopus 로고    scopus 로고
    • Materials science. Multitasking in tissues and materials
    • Messersmith, P.B. Materials science. Multitasking in tissues and materials. Science 319, 1767, 2008.
    • (2008) Science , vol.319 , pp. 1767
    • Messersmith, P.B.1
  • 3
    • 0033917881 scopus 로고    scopus 로고
    • Cell movement is guided by the rigidity of the substrate
    • Lo, C.M., Wang, H.B., Dembo, M., and Wang, Y. Cell movement is guided by the rigidity of the substrate. Biophys J 79, 144, 2000.
    • (2000) Biophys J , vol.79 , pp. 144
    • Lo, C.M.1    Wang, H.B.2    Dembo, M.3    Wang, Y.4
  • 4
    • 21244432037 scopus 로고    scopus 로고
    • Collective movement of epithelial cells on a collagen gel substrate
    • Haga, H., Irahara, C., Kobayashi, R., Nakagaki, T., and Kawabata, K. Collective movement of epithelial cells on a collagen gel substrate. Biophys J 88, 2250, 2005.
    • (2005) Biophys J , vol.88 , pp. 2250
    • Haga, H.1    Irahara, C.2    Kobayashi, R.3    Nakagaki, T.4    Kawabata, K.5
  • 5
    • 20444442344 scopus 로고    scopus 로고
    • Electrophoresis: The march of pennies, the march of dimes
    • Righetti, P.G. Electrophoresis: the march of pennies, the march of dimes. J Chromatogr A 1079, 24, 2005.
    • (2005) J Chromatogr A , vol.1079 , pp. 24
    • Righetti, P.G.1
  • 6
    • 37549063934 scopus 로고    scopus 로고
    • Dielectrophoresis for the manipulation of nanobioparticles
    • Lapizco-Encinas, B.H., and Rito-Palomares, M. Dielectrophoresis for the manipulation of nanobioparticles. Electrophoresis 28, 4521, 2007.
    • (2007) Electrophoresis , vol.28 , pp. 4521
    • Lapizco-Encinas, B.H.1    Rito-Palomares, M.2
  • 7
    • 0025556925 scopus 로고
    • Recent development status of functionally gradient materials
    • Niino, M., and Maeda, S. Recent development status of functionally gradient materials. ISIJ Int 30, 699, 1990.
    • (1990) ISIJ Int , vol.30 , pp. 699
    • Niino, M.1    Maeda, S.2
  • 9
    • 33846188184 scopus 로고    scopus 로고
    • In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method
    • Oh, S.H., Park, I.K., Kim, J.M., and Lee, J.H. In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 28, 1664, 2007.
    • (2007) Biomaterials , vol.28 , pp. 1664
    • Oh, S.H.1    Park, I.K.2    Kim, J.M.3    Lee, J.H.4
  • 10
    • 0035671158 scopus 로고    scopus 로고
    • The design of scaffolds for use in tissue engineering. Part I. Traditional factors
    • Yang, S., Leong, K.F., Du, Z., and Chua, C.K. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 7, 679, 2001.
    • (2001) Tissue Eng , vol.7 , pp. 679
    • Yang, S.1    Leong, K.F.2    Du, Z.3    Chua, C.K.4
  • 11
    • 17844400927 scopus 로고    scopus 로고
    • Porosity of 3D biomaterial scaffolds and osteogenesis
    • Karageorgiou, V., and Kaplan, D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26, 5474, 2005.
    • (2005) Biomaterials , vol.26 , pp. 5474
    • Karageorgiou, V.1    Kaplan, D.2
  • 13
    • 0035885558 scopus 로고    scopus 로고
    • Microtubular architecture of biodegradable polymer scaffolds
    • Ma, P.X., and Zhang, R. Microtubular architecture of biodegradable polymer scaffolds. J Biomed Mater Res 56, 469, 2001.
    • (2001) J Biomed Mater Res , vol.56 , pp. 469
    • Ma, P.X.1    Zhang, R.2
  • 14
    • 0035988660 scopus 로고    scopus 로고
    • Tailoring the pore architecture in 3-D alginate scaffolds by controlling the freezing regime during fabrication
    • Zmora, S., Glicklis, R., and Cohen, S. Tailoring the pore architecture in 3-D alginate scaffolds by controlling the freezing regime during fabrication. Biomaterials 23, 4087, 2002.
    • (2002) Biomaterials , vol.23 , pp. 4087
    • Zmora, S.1    Glicklis, R.2    Cohen, S.3
  • 15
    • 0034765279 scopus 로고    scopus 로고
    • Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition
    • Zeltinger, J., Sherwood, J.K., Graham, D.A., Mueller, R., and Griffith, L.G. Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition. Tissue Eng 7, 557, 2001.
    • (2001) Tissue Eng , vol.7 , pp. 557
    • Zeltinger, J.1    Sherwood, J.K.2    Graham, D.A.3    Mueller, R.4    Griffith, L.G.5
  • 16
    • 27744606356 scopus 로고    scopus 로고
    • Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs
    • Woodfield, T.B., van Blitterswijk, C.A., de Wijn, J., Sims, T.J., Hollander, A.P., and Riesle, J. Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs. Tissue Eng 11, 1297, 2005.
    • (2005) Tissue Eng , vol.11 , pp. 1297
    • Woodfield, T.B.1    van Blitterswijk, C.A.2    de Wijn, J.3    Sims, T.J.4    Hollander, A.P.5    Riesle, J.6
  • 18
    • 0032271870 scopus 로고    scopus 로고
    • Hierarchically structured polyglycolide - a biomaterial mimicking natural bone
    • Schwarz, K., and Epple, M. Hierarchically structured polyglycolide - a biomaterial mimicking natural bone. Macromol Rapid Commun 19, 613, 1998.
    • (1998) Macromol Rapid Commun , vol.19 , pp. 613
    • Schwarz, K.1    Epple, M.2
  • 19
    • 26944501957 scopus 로고    scopus 로고
    • Fabricating tubular scaffolds with a radial pore size gradient by a spinning technique
    • Harley, B.A., Hastings, A.Z., Yannas, I.V., and Sannino, A. Fabricating tubular scaffolds with a radial pore size gradient by a spinning technique. Biomaterials 27, 866, 2006.
    • (2006) Biomaterials , vol.27 , pp. 866
    • Harley, B.A.1    Hastings, A.Z.2    Yannas, I.V.3    Sannino, A.4
  • 20
    • 0344306399 scopus 로고    scopus 로고
    • Performance of degradable composite bone repair products made via three-dimensional fabrication techniques
    • Roy, T.D., Simon, J.L., Ricci, J.L., Rekow, E.D., Thompson, V.P., and Parsons, J.R. Performance of degradable composite bone repair products made via three-dimensional fabrication techniques. J Biomed Mater Res A 66, 283, 2003.
    • (2003) J Biomed Mater Res A , vol.66 , pp. 283
    • Roy, T.D.1    Simon, J.L.2    Ricci, J.L.3    Rekow, E.D.4    Thompson, V.P.5    Parsons, J.R.6
  • 24
    • 27944497333 scopus 로고    scopus 로고
    • Tissue cells feel and respond to the stiffness of their substrate
    • Discher, D.E., Janmey, P., and Wang, Y. Tissue cells feel and respond to the stiffness of their substrate. Science 310, 1139, 2005.
    • (2005) Science , vol.310 , pp. 1139
    • Discher, D.E.1    Janmey, P.2    Wang, Y.3
  • 25
    • 33847016946 scopus 로고    scopus 로고
    • Soft matters in cell adhesion: Rigidity sensing on soft elastic substrates
    • Schwarz, U. Soft matters in cell adhesion: rigidity sensing on soft elastic substrates. Soft Matter 3, 263, 2007.
    • (2007) Soft Matter , vol.3 , pp. 263
    • Schwarz, U.1
  • 26
    • 23844518057 scopus 로고    scopus 로고
    • Biochemistry and biomechanics of cell motility
    • Li, S., Guan, J.L., and Chien, S. Biochemistry and biomechanics of cell motility. Annu Rev Biomed Eng 7, 105, 2005.
    • (2005) Annu Rev Biomed Eng , vol.7 , pp. 105
    • Li, S.1    Guan, J.L.2    Chien, S.3
  • 27
    • 0344912596 scopus 로고    scopus 로고
    • Cell locomotion and focal adhesions are regulated by substrate flexibility
    • Pelham, R.J., Jr., and Wang, Y. Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci USA 94, 13661, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13661
    • Pelham Jr., R.J.1    Wang, Y.2
  • 29
    • 0037418433 scopus 로고    scopus 로고
    • Directed movement of vascular smooth muscle cells on gradient-compliant hydrogels
    • Wong, J.Y., Velasco, A., Rajagopalan, P., and Pham, Q. Directed movement of vascular smooth muscle cells on gradient-compliant hydrogels. Langmuir 19, 1908, 2003.
    • (2003) Langmuir , vol.19 , pp. 1908
    • Wong, J.Y.1    Velasco, A.2    Rajagopalan, P.3    Pham, Q.4
  • 30
    • 11344288033 scopus 로고    scopus 로고
    • Photopolymerization in microfluidic gradient generators: Microscale control of substrate compliance to manipulate cell response
    • Zaari, N., Rajagopalan, P., Kim, S.K., Engler, A.J., and Wong, J.Y. Photopolymerization in microfluidic gradient generators: microscale control of substrate compliance to manipulate cell response. Adv Mater 16, 2133, 2004.
    • (2004) Adv Mater , vol.16 , pp. 2133
    • Zaari, N.1    Rajagopalan, P.2    Kim, S.K.3    Engler, A.J.4    Wong, J.Y.5
  • 31
    • 0344306445 scopus 로고    scopus 로고
    • Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus
    • Gray, D.S., Tien, J., and Chen, C.S. Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus. J Biomed Mater Res 66, 605, 2003.
    • (2003) J Biomed Mater Res , vol.66 , pp. 605
    • Gray, D.S.1    Tien, J.2    Chen, C.S.3
  • 32
    • 37249063216 scopus 로고    scopus 로고
    • Microelastic gradient gelatinous gels to induce cellular mechanotaxis
    • Kidoaki, S., and Matsuda, T. Microelastic gradient gelatinous gels to induce cellular mechanotaxis. J Biotechnol 133, 225, 2008.
    • (2008) J Biotechnol , vol.133 , pp. 225
    • Kidoaki, S.1    Matsuda, T.2
  • 33
    • 15444368220 scopus 로고    scopus 로고
    • Cell type-specific response to growth on soft materials
    • Georges, P.C., and Janmey, P.A. Cell type-specific response to growth on soft materials. Am Physiol Soc 98, 1547, 2005.
    • (2005) Am Physiol Soc , vol.98 , pp. 1547
    • Georges, P.C.1    Janmey, P.A.2
  • 35
    • 33646005836 scopus 로고    scopus 로고
    • Substrate rigidity regulates the formation and maintenance of tissues
    • Guo, W., Frey, M.T., Burnham, N.A., and Wang, Y. Substrate rigidity regulates the formation and maintenance of tissues. Biophys J 90, 2213, 2006.
    • (2006) Biophys J , vol.90 , pp. 2213
    • Guo, W.1    Frey, M.T.2    Burnham, N.A.3    Wang, Y.4
  • 37
    • 4544250739 scopus 로고    scopus 로고
    • Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: Correlations between substrate stiffness and cell adhesion
    • Engler, A.J., Richert, L., Wong, J.Y., Picart, C., and Discher, D.E. Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: correlations between substrate stiffness and cell adhesion. Surf Sci 570, 142, 2004.
    • (2004) Surf Sci , vol.570 , pp. 142
    • Engler, A.J.1    Richert, L.2    Wong, J.Y.3    Picart, C.4    Discher, D.E.5
  • 38
    • 4544264684 scopus 로고    scopus 로고
    • Myotubes differentiate optimally on substrates with tissue-like stiffness: Pathological implications for soft or stiff microenvironments
    • Engler, A.J., Griffin, M.A., Sen, S., Bonnemann, C.G., Sweeney, H.L., and Discher, D.E. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol 166, 877, 2004.
    • (2004) J Cell Biol , vol.166 , pp. 877
    • Engler, A.J.1    Griffin, M.A.2    Sen, S.3    Bonnemann, C.G.4    Sweeney, H.L.5    Discher, D.E.6
  • 39
    • 20144365546 scopus 로고    scopus 로고
    • Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion
    • Peyton, S.R., and Putnam, A.J. Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion. J Cell Physiol 204, 198, 2005.
    • (2005) J Cell Physiol , vol.204 , pp. 198
    • Peyton, S.R.1    Putnam, A.J.2
  • 40
    • 33751558937 scopus 로고    scopus 로고
    • A simple microindentation technique for mapping the microscale compliance of soft hydrated materials and tissues
    • Jacot, J.G., Dianis, S., Schnall, J., and Wong, J.Y. A simple microindentation technique for mapping the microscale compliance of soft hydrated materials and tissues. J Biomed Mater Res A 79, 485, 2006.
    • (2006) J Biomed Mater Res A , vol.79 , pp. 485
    • Jacot, J.G.1    Dianis, S.2    Schnall, J.3    Wong, J.Y.4
  • 41
    • 28744437783 scopus 로고    scopus 로고
    • Combinatorial investigation of the structure-properties characterization of photopolymerized dimethacrylate networks
    • Lin-Gibson, S., Landis, F.A., and Drzal, P.L. Combinatorial investigation of the structure-properties characterization of photopolymerized dimethacrylate networks. Biomaterials 27, 1711, 2006.
    • (2006) Biomaterials , vol.27 , pp. 1711
    • Lin-Gibson, S.1    Landis, F.A.2    Drzal, P.L.3
  • 42
    • 3042635684 scopus 로고    scopus 로고
    • Fabrication of gradient hydrogels using a microfluidics/photopolymerization process
    • Burdick, J.A., Khademhosseini, A., and Langer, R. Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir 20, 5153, 2004.
    • (2004) Langmuir , vol.20 , pp. 5153
    • Burdick, J.A.1    Khademhosseini, A.2    Langer, R.3
  • 43
    • 0030680814 scopus 로고    scopus 로고
    • Preparation and characterization of chemical gradient surfaces and their application for the study of cellular interaction phenomena
    • Ruardy, T.G., Schakenraad, J.M., van Der Mei, H.C., and Busscher, H.J. Preparation and characterization of chemical gradient surfaces and their application for the study of cellular interaction phenomena. Surf Sci Rep 29, 1, 1997.
    • (1997) Surf Sci Rep , vol.29 , pp. 1
    • Ruardy, T.G.1    Schakenraad, J.M.2    van Der Mei, H.C.3    Busscher, H.J.4
  • 44
    • 0001267282 scopus 로고
    • Cellular responses on a wettability gradient surface with continuous variations in surface compositions of carbonate and hydroxyl groups
    • Ueda-Yukoshi, T., and Matsuda, T. Cellular responses on a wettability gradient surface with continuous variations in surface compositions of carbonate and hydroxyl groups. Langmuir 11, 4135, 1995.
    • (1995) Langmuir , vol.11 , pp. 4135
    • Ueda-Yukoshi, T.1    Matsuda, T.2
  • 45
    • 0037076637 scopus 로고    scopus 로고
    • Spatial dispersion in electrochemically generated surface composition gradients visualized with covalently bound fluorescent nanospheres
    • Plummer, S.T., and Bohn, P.W. Spatial dispersion in electrochemically generated surface composition gradients visualized with covalently bound fluorescent nanospheres. Langmuir 18, 4142, 2002.
    • (2002) Langmuir , vol.18 , pp. 4142
    • Plummer, S.T.1    Bohn, P.W.2
  • 46
    • 7444241372 scopus 로고    scopus 로고
    • A technique for preparing protein gradients on polymeric surfaces: Effects on PC12 pheochromocytoma cells
    • Li, B., Ma, Y., Wang, S., and Moran, P.M. A technique for preparing protein gradients on polymeric surfaces: effects on PC12 pheochromocytoma cells. Biomaterials 26, 1487, 2005.
    • (2005) Biomaterials , vol.26 , pp. 1487
    • Li, B.1    Ma, Y.2    Wang, S.3    Moran, P.M.4
  • 47
    • 37249089490 scopus 로고    scopus 로고
    • Gradient polymer surfaces for biomedical applications
    • Kim, M.S., Khang, G., and Lee, H.B. Gradient polymer surfaces for biomedical applications. Prog Polym Sci 33, 138, 2008.
    • (2008) Prog Polym Sci , vol.33 , pp. 138
    • Kim, M.S.1    Khang, G.2    Lee, H.B.3
  • 48
    • 42149136178 scopus 로고    scopus 로고
    • Surface-bound soft matter gradients
    • Genzer, J., and Bhat, R.R. Surface-bound soft matter gradients. Langmuir 24, 2294, 2008.
    • (2008) Langmuir , vol.24 , pp. 2294
    • Genzer, J.1    Bhat, R.R.2
  • 49
    • 33646365074 scopus 로고    scopus 로고
    • Combinatorial screen of the effect of surface energy on fibronectin-mediated osteoblast adhesion, spreading and proliferation
    • Kennedy, S.B., Washburn, N.R., Simon, C.G., and Amis, E.J. Combinatorial screen of the effect of surface energy on fibronectin-mediated osteoblast adhesion, spreading and proliferation. Biomaterials 27, 3817, 2006.
    • (2006) Biomaterials , vol.27 , pp. 3817
    • Kennedy, S.B.1    Washburn, N.R.2    Simon, C.G.3    Amis, E.J.4
  • 50
    • 0344095399 scopus 로고    scopus 로고
    • Time-of-flight secondary ion mass spectrometry (TOF-SIMS) for high-throughput characterization of biosurfaces
    • Roberson, S., Sehgal, A., Fahey, A., and Karim, A. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) for high-throughput characterization of biosurfaces. Appl Surf Sci 203, 855, 2003.
    • (2003) Appl Surf Sci , vol.203 , pp. 855
    • Roberson, S.1    Sehgal, A.2    Fahey, A.3    Karim, A.4
  • 51
    • 24344450285 scopus 로고    scopus 로고
    • Gradient chemical micropatterns: A reference substrate for surface nanometrology
    • Julthongpiput, D., Fasolka, M.J., Zhang, W., Nguyen, T., and Amis, E.J. Gradient chemical micropatterns: a reference substrate for surface nanometrology. Nano Lett 5, 1535, 2005.
    • (2005) Nano Lett , vol.5 , pp. 1535
    • Julthongpiput, D.1    Fasolka, M.J.2    Zhang, W.3    Nguyen, T.4    Amis, E.J.5
  • 52
    • 0036403674 scopus 로고    scopus 로고
    • Adhesion of blood platelets under flow to wettability gradient polyethylene surfaces made in a shielded gas plasma
    • Spijker, H.T., Bos, R., Busscher, H.J., Graaff, R., and van Oeveren, W. Adhesion of blood platelets under flow to wettability gradient polyethylene surfaces made in a shielded gas plasma. J Adhes Sci Technol 16, 1703, 2002.
    • (2002) J Adhes Sci Technol , vol.16 , pp. 1703
    • Spijker, H.T.1    Bos, R.2    Busscher, H.J.3    Graaff, R.4    van Oeveren, W.5
  • 53
    • 0036132492 scopus 로고    scopus 로고
    • Platelet adhesion and activation on a shielded plasma gradient prepared on polyethylene
    • Spijker, H.T., Bos, R., Busscher, H.J., van Kooten, T.G., and van Oeveren, W. Platelet adhesion and activation on a shielded plasma gradient prepared on polyethylene. Biomaterials 23, 757, 2002.
    • (2002) Biomaterials , vol.23 , pp. 757
    • Spijker, H.T.1    Bos, R.2    Busscher, H.J.3    van Kooten, T.G.4    van Oeveren, W.5
  • 54
    • 0000289366 scopus 로고
    • Fabrication of a continuous wettability gradient by radio frequency plasma discharge
    • Pitt, W.G. Fabrication of a continuous wettability gradient by radio frequency plasma discharge. J Colloid Interface Sci 133, 223, 1989.
    • (1989) J Colloid Interface Sci , vol.133 , pp. 223
    • Pitt, W.G.1
  • 55
    • 0025216820 scopus 로고
    • Characterization of hydrophobicity gradients prepared by means of radio frequency plasma discharge
    • Golander, C.G., and Pitt, W.G. Characterization of hydrophobicity gradients prepared by means of radio frequency plasma discharge. Biomaterials 11, 32, 1990.
    • (1990) Biomaterials , vol.11 , pp. 32
    • Golander, C.G.1    Pitt, W.G.2
  • 56
    • 44049120496 scopus 로고
    • Characterization of wettability gradient surfaces prepared by corona discharge treatment
    • Lee, J., Kim, H.G.I., Khang, G., Lee, H., and Jhon, M.U.S. Characterization of wettability gradient surfaces prepared by corona discharge treatment. J Colloid Interface Sci 151, 563, 1992.
    • (1992) J Colloid Interface Sci , vol.151 , pp. 563
    • Lee, J.1    Kim, H.G.I.2    Khang, G.3    Lee, H.4    Jhon, M.U.S.5
  • 57
    • 0027349584 scopus 로고
    • A wettability gradient as a tool to study protein adsorption and cell adhesion on polymer surfaces
    • Lee, J.H., and Lee, H.B. A wettability gradient as a tool to study protein adsorption and cell adhesion on polymer surfaces. J Biomater Sci Polym Ed 4, 467, 1993.
    • (1993) J Biomater Sci Polym Ed , vol.4 , pp. 467
    • Lee, J.H.1    Lee, H.B.2
  • 58
    • 0032530862 scopus 로고    scopus 로고
    • Interaction of different types of cells on polymer surfaces with wettability gradient
    • Lee, J.H., Khang, G., Lee, J.W., and Lee, H.B. Interaction of different types of cells on polymer surfaces with wettability gradient. J Colloid Interface Sci 205, 323, 1998.
    • (1998) J Colloid Interface Sci , vol.205 , pp. 323
    • Lee, J.H.1    Khang, G.2    Lee, J.W.3    Lee, H.B.4
  • 59
    • 0037444131 scopus 로고    scopus 로고
    • The effect of surface wettability on induction and growth of neurites from the PC-12 cell on a polymer surface
    • Lee, S.J., Khang, G., Lee, Y.M., and Lee, H.B. The effect of surface wettability on induction and growth of neurites from the PC-12 cell on a polymer surface. J Colloid Interface Sci 259, 228, 2003.
    • (2003) J Colloid Interface Sci , vol.259 , pp. 228
    • Lee, S.J.1    Khang, G.2    Lee, Y.M.3    Lee, H.B.4
  • 60
    • 0000098436 scopus 로고    scopus 로고
    • Platelet adhesion onto wettability gradient surfaces in the absence and presence of plasma proteins
    • Lee, J.H., and Lee, H.B. Platelet adhesion onto wettability gradient surfaces in the absence and presence of plasma proteins. J Biomed Mater Res 41, 304, 1998.
    • (1998) J Biomed Mater Res , vol.41 , pp. 304
    • Lee, J.H.1    Lee, H.B.2
  • 61
    • 1542577110 scopus 로고    scopus 로고
    • Proliferation rate of fibroblast cells on polyethylene surfaces with wettability gradient
    • Choee, J.H., Lee, S.J., Lee, Y.M., Rhee, J.M., Lee, H.B., and Khang, G. Proliferation rate of fibroblast cells on polyethylene surfaces with wettability gradient. J Appl Polym Sci 92, 599, 2004.
    • (2004) J Appl Polym Sci , vol.92 , pp. 599
    • Choee, J.H.1    Lee, S.J.2    Lee, Y.M.3    Rhee, J.M.4    Lee, H.B.5    Khang, G.6
  • 62
    • 2442754072 scopus 로고    scopus 로고
    • Interaction of fibroblast cells on poly (lactide-co-glycolide) surface with wettability chemogradient
    • Khang, G. Interaction of fibroblast cells on poly (lactide-co-glycolide) surface with wettability chemogradient. Biomed Mater Eng 9, 179, 1999.
    • (1999) Biomed Mater Eng , vol.9 , pp. 179
    • Khang, G.1
  • 63
    • 0033047322 scopus 로고    scopus 로고
    • Interaction of fibroblasts on polycarbonate membrane surfaces with different micropore sizes and hydrophilicity
    • Lee, J.H., Lee, S.J., Khang, G., and Lee, H.B. Interaction of fibroblasts on polycarbonate membrane surfaces with different micropore sizes and hydrophilicity. J Biomater Sci Polym Ed 10, 283, 1999.
    • (1999) J Biomater Sci Polym Ed , vol.10 , pp. 283
    • Lee, J.H.1    Lee, S.J.2    Khang, G.3    Lee, H.B.4
  • 64
    • 14844346488 scopus 로고    scopus 로고
    • Influence of carboxyl group density on neuron cell attachment and differentiation behavior: Gradient-guided neurite outgrowth
    • Li, B., Ma, Y., Wang, S., and Moran, P.M. Influence of carboxyl group density on neuron cell attachment and differentiation behavior: gradient-guided neurite outgrowth. Biomaterials 26, 4956, 2005.
    • (2005) Biomaterials , vol.26 , pp. 4956
    • Li, B.1    Ma, Y.2    Wang, S.3    Moran, P.M.4
  • 65
    • 12644260439 scopus 로고    scopus 로고
    • Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo (ethylene glycol) alkanethiolates
    • Herbert, C.B., McLernon, T.L., Hypolite, C.L., Adams, D.N., Pikus, L., Huang, C.C., Fields, G.B., Letourneau, P.C., Distefano, M.D., and Hu, W.S. Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo (ethylene glycol) alkanethiolates. Chem Biol 4, 731, 1997.
    • (1997) Chem Biol , vol.4 , pp. 731
    • Herbert, C.B.1    McLernon, T.L.2    Hypolite, C.L.3    Adams, D.N.4    Pikus, L.5    Huang, C.C.6    Fields, G.B.7    Letourneau, P.C.8    Distefano, M.D.9    Hu, W.S.10
  • 68
    • 0031035270 scopus 로고    scopus 로고
    • Plasma protein adsorption and platelet adhesion onto comb-like PEO gradient surfaces
    • Lee, J.H., Jeong, B.J., and Lee, H.B. Plasma protein adsorption and platelet adhesion onto comb-like PEO gradient surfaces. J Biomed Mater Res 34, 105, 1997.
    • (1997) J Biomed Mater Res , vol.34 , pp. 105
    • Lee, J.H.1    Jeong, B.J.2    Lee, H.B.3
  • 69
    • 0029974787 scopus 로고    scopus 로고
    • Preparation and characterization of comb-like PEO gradient surfaces
    • Jeong, B.J., Lee, J.H., and Lee, H.B. Preparation and characterization of comb-like PEO gradient surfaces. J Colloid Interface Sci 178, 757, 1996.
    • (1996) J Colloid Interface Sci , vol.178 , pp. 757
    • Jeong, B.J.1    Lee, J.H.2    Lee, H.B.3
  • 70
    • 0031080912 scopus 로고    scopus 로고
    • Interaction of cells on chargeable functional group gradient surfaces
    • Lee, J.H., Lee, J.W., Khang, G., and Lee, H.B. Interaction of cells on chargeable functional group gradient surfaces. Biomaterials 18, 351, 1997.
    • (1997) Biomaterials , vol.18 , pp. 351
    • Lee, J.H.1    Lee, J.W.2    Khang, G.3    Lee, H.B.4
  • 71
    • 0032060152 scopus 로고    scopus 로고
    • Platelet adhesion onto chargeable functional group gradient surfaces
    • Lee, J.H., Khang, G., Lee, J.W., and Lee, H.B. Platelet adhesion onto chargeable functional group gradient surfaces. J Biomed Mater Res 40, 180, 1998.
    • (1998) J Biomed Mater Res , vol.40 , pp. 180
    • Lee, J.H.1    Khang, G.2    Lee, J.W.3    Lee, H.B.4
  • 73
    • 0032878231 scopus 로고    scopus 로고
    • The effect of the chemical structure of the phospholipid polymer on fibronectin adsorption and fibroblast adhesion on the gradient phospholipid surface
    • Iwasaki, Y., Sawada, S., Nakabayashi, N., Khang, G., Bang Lee, H., and Ishihara, K. The effect of the chemical structure of the phospholipid polymer on fibronectin adsorption and fibroblast adhesion on the gradient phospholipid surface. Biomaterials 20, 2185, 1999.
    • (1999) Biomaterials , vol.20 , pp. 2185
    • Iwasaki, Y.1    Sawada, S.2    Nakabayashi, N.3    Khang, G.4    Bang Lee, H.5    Ishihara, K.6
  • 74
    • 0037963643 scopus 로고    scopus 로고
    • A method for the deposition of controllable chemical gradients
    • Whittle, J.D., Barton, D., Alexander, M.R., and Short, R.D. A method for the deposition of controllable chemical gradients. Chem Commun 2003, 1766, 2003.
    • (2003) Chem Commun , vol.2003 , pp. 1766
    • Whittle, J.D.1    Barton, D.2    Alexander, M.R.3    Short, R.D.4
  • 76
    • 1242297732 scopus 로고    scopus 로고
    • Plasma polymer chemical gradients for evaluation of surface reactivity: Epoxide reaction with carboxylic acid surface groups
    • Alexander, M.R., Whittle, J.D., Barton, D., and Short, R.D. Plasma polymer chemical gradients for evaluation of surface reactivity: epoxide reaction with carboxylic acid surface groups. J Mater Chem 14, 408, 2004.
    • (2004) J Mater Chem , vol.14 , pp. 408
    • Alexander, M.R.1    Whittle, J.D.2    Barton, D.3    Short, R.D.4
  • 77
    • 35548944066 scopus 로고    scopus 로고
    • Investigation of cell-surface interactions using chemical gradients formed from plasma polymers
    • Zelzer, M., Majani, R., Bradley, J.W., Rose, F.R., Davies, M.C., and Alexander, M.R. Investigation of cell-surface interactions using chemical gradients formed from plasma polymers. Biomaterials 29, 172, 2008.
    • (2008) Biomaterials , vol.29 , pp. 172
    • Zelzer, M.1    Majani, R.2    Bradley, J.W.3    Rose, F.R.4    Davies, M.C.5    Alexander, M.R.6
  • 79
    • 0000511213 scopus 로고
    • A wettability gradient method for studies of macromolecular interactions at the liquid/solid interface
    • Elwing, H., Welin, S., Askendal, A., Nilsson, U., and Lundstrom, I. A wettability gradient method for studies of macromolecular interactions at the liquid/solid interface. J Colloid Interface Sci 119, 203, 1987.
    • (1987) J Colloid Interface Sci , vol.119 , pp. 203
    • Elwing, H.1    Welin, S.2    Askendal, A.3    Nilsson, U.4    Lundstrom, I.5
  • 80
    • 0023398010 scopus 로고
    • Competition between adsorbed fibrinogen and high-molecular-weight kininogen on solid surfaces incubated in human plasma (the Vroman effect): Influence of solid surface wettability
    • Elwing, H., Askendal, A., and Lundstrom, I. Competition between adsorbed fibrinogen and high-molecular-weight kininogen on solid surfaces incubated in human plasma (the Vroman effect): influence of solid surface wettability. J Biomed Mater Res 21, 1023, 1987.
    • (1987) J Biomed Mater Res , vol.21 , pp. 1023
    • Elwing, H.1    Askendal, A.2    Lundstrom, I.3
  • 81
    • 0006845156 scopus 로고
    • Protein exchange reactions on solid surfaces studied with a wettability gradient method
    • Elwing, H., Askendal, A., and Lundström, I. Protein exchange reactions on solid surfaces studied with a wettability gradient method. Colloid Polym Sci 74, 103, 1987.
    • (1987) Colloid Polym Sci , vol.74 , pp. 103
    • Elwing, H.1    Askendal, A.2    Lundström, I.3
  • 82
    • 0001213890 scopus 로고
    • Spatially resolved adsorption kinetics of immunoglobulin G onto the wettability gradient surface
    • Hlady, V. Spatially resolved adsorption kinetics of immunoglobulin G onto the wettability gradient surface. Appl Spectrosc 45, 246, 1991.
    • (1991) Appl Spectrosc , vol.45 , pp. 246
    • Hlady, V.1
  • 83
    • 0001324365 scopus 로고
    • How to make water run uphill
    • Chaudhury, M.K., and Whitesides, G.M. How to make water run uphill. Science 256, 1539, 1992.
    • (1992) Science , vol.256 , pp. 1539
    • Chaudhury, M.K.1    Whitesides, G.M.2
  • 84
    • 0024876861 scopus 로고
    • A new technique to prepare gradient surfaces using density gradient solutions
    • Golander, C.G., Caldwell, K., and Lin, Y.S. A new technique to prepare gradient surfaces using density gradient solutions. Colloids Surf 42, 165, 1989.
    • (1989) Colloids Surf , vol.42 , pp. 165
    • Golander, C.G.1    Caldwell, K.2    Lin, Y.S.3
  • 85
    • 56749176524 scopus 로고
    • Preparation of chemical gradient surfaces by hyperthermal polyatomic ion deposition: A new method for combinatorial materials science
    • Wijesundara, M.B.J., Fuoco, E., and Hanley, L. Preparation of chemical gradient surfaces by hyperthermal polyatomic ion deposition: a new method for combinatorial materials science. J Colloid Interface Sci 119, 203, 1987.
    • (1987) J Colloid Interface Sci , vol.119 , pp. 203
    • Wijesundara, M.B.J.1    Fuoco, E.2    Hanley, L.3
  • 86
    • 0345376888 scopus 로고    scopus 로고
    • A combinatorial approach to surface anchored polymers
    • Wu, T., Tomlinson, M., Efimenko, K., and Genzer, J. A combinatorial approach to surface anchored polymers. J Mater Sci 38, 4471, 2003.
    • (2003) J Mater Sci , vol.38 , pp. 4471
    • Wu, T.1    Tomlinson, M.2    Efimenko, K.3    Genzer, J.4
  • 87
    • 11144235561 scopus 로고    scopus 로고
    • A combinatorial approach to study solvent-induced self-assembly of mixed poly (methyl methacrylate)/polystyrene brushes on planar silica substrates: Effect of relative grafting density
    • Zhao, B. A combinatorial approach to study solvent-induced self-assembly of mixed poly (methyl methacrylate)/polystyrene brushes on planar silica substrates: effect of relative grafting density. Langmuir 20, 11748, 2004.
    • (2004) Langmuir , vol.20 , pp. 11748
    • Zhao, B.1
  • 88
    • 30644472658 scopus 로고    scopus 로고
    • Orthogonal surface-grafted polymer gradients: A versatile combinatorial platform
    • Bhat, R.R., Tomlinson, M.R., and Genzer, J. Orthogonal surface-grafted polymer gradients: a versatile combinatorial platform. J Polym Sci B Polym Phys 43, 3384, 2005.
    • (2005) J Polym Sci B Polym Phys , vol.43 , pp. 3384
    • Bhat, R.R.1    Tomlinson, M.R.2    Genzer, J.3
  • 89
    • 36749046965 scopus 로고    scopus 로고
    • Fabrication of a nanoparticle gradient substrate by thermochemical manipulation of an ester functionalized SAM
    • Iqbal, P., Critchley, K., Bowen, J., Attwood, D., Tunnicliffe, D., Evans, S.D., and Preece, J.A. Fabrication of a nanoparticle gradient substrate by thermochemical manipulation of an ester functionalized SAM. J Mater Chem 17, 5097, 2007.
    • (2007) J Mater Chem , vol.17 , pp. 5097
    • Iqbal, P.1    Critchley, K.2    Bowen, J.3    Attwood, D.4    Tunnicliffe, D.5    Evans, S.D.6    Preece, J.A.7
  • 90
    • 0348170920 scopus 로고    scopus 로고
    • A simple, reproducible approach to the preparation of surface-chemical gradients
    • Morgenthaler, S., Lee, S., Zurcher, S., and Spencer, N.D. A simple, reproducible approach to the preparation of surface-chemical gradients. Langmuir 19, 10459, 2003.
    • (2003) Langmuir , vol.19 , pp. 10459
    • Morgenthaler, S.1    Lee, S.2    Zurcher, S.3    Spencer, N.D.4
  • 91
    • 56749097575 scopus 로고    scopus 로고
    • Morgenthaler, S., Zink, C., Städler, B., Vörös, J., Lee, S., Spencer, N.D., and Tosatti, S.G.P. Poly (L-lysine)-grafted-poly (ethylene glycol)-based surface-chemical gradients. Preparation, characterization, and first applications. Biointerphases 1, 156, 2006.
    • Morgenthaler, S., Zink, C., Städler, B., Vörös, J., Lee, S., Spencer, N.D., and Tosatti, S.G.P. Poly (L-lysine)-grafted-poly (ethylene glycol)-based surface-chemical gradients. Preparation, characterization, and first applications. Biointerphases 1, 156, 2006.
  • 92
    • 34548421614 scopus 로고    scopus 로고
    • Kunzler, T.P., Huwiler, C., Drobek, T., Vöro8s, J., and Spencer, N.D. Systematic study of osteoblast response to nanotopography by means of nanoparticle-density gradients. Biomaterials 28, 5000, 2007.
    • Kunzler, T.P., Huwiler, C., Drobek, T., Vöro8s, J., and Spencer, N.D. Systematic study of osteoblast response to nanotopography by means of nanoparticle-density gradients. Biomaterials 28, 5000, 2007.
  • 93
    • 2342460928 scopus 로고    scopus 로고
    • Preparation of protein gradients through the controlled deposition of protein-nanoparticle conjugates onto functionalized surfaces
    • Krämer, S., Xie, H., Gaff, J., Williamson, J.R., Tkachenko, A.G., Nouri, N., Feldheim, D.A., and Feldheim, D.L. Preparation of protein gradients through the controlled deposition of protein-nanoparticle conjugates onto functionalized surfaces. J Am Chem Soc 126, 5388, 2004.
    • (2004) J Am Chem Soc , vol.126 , pp. 5388
    • Krämer, S.1    Xie, H.2    Gaff, J.3    Williamson, J.R.4    Tkachenko, A.G.5    Nouri, N.6    Feldheim, D.A.7    Feldheim, D.L.8
  • 94
    • 0442326065 scopus 로고    scopus 로고
    • Combinatorial methods, automated synthesis and high-throughput screening in polymer research: The evolution continues
    • Meier, M.A.R., Hoogenboom, R., and Schubert, U.S. Combinatorial methods, automated synthesis and high-throughput screening in polymer research: the evolution continues. Macromol Rapid Commun 25, 21, 2004.
    • (2004) Macromol Rapid Commun , vol.25 , pp. 21
    • Meier, M.A.R.1    Hoogenboom, R.2    Schubert, U.S.3
  • 95
    • 9644265361 scopus 로고    scopus 로고
    • Combinatorial polymer research and high-throughput experimentation: Powerful tools for the discovery and evaluation of new materials
    • Meier, M.A.R., and Schubert, U.S. Combinatorial polymer research and high-throughput experimentation: powerful tools for the discovery and evaluation of new materials. J Mater Chem 14, 3289, 2004.
    • (2004) J Mater Chem , vol.14 , pp. 3289
    • Meier, M.A.R.1    Schubert, U.S.2
  • 96
    • 30444437687 scopus 로고    scopus 로고
    • Combinatorial study of surface pattern formation in thin block copolymer films
    • Smith, A.P., Douglas, J.F., Meredith, J.C., Amis, E.J., and Karim, A. Combinatorial study of surface pattern formation in thin block copolymer films. Phys Rev Lett 87, 15503, 2001.
    • (2001) Phys Rev Lett , vol.87 , pp. 15503
    • Smith, A.P.1    Douglas, J.F.2    Meredith, J.C.3    Amis, E.J.4    Karim, A.5
  • 97
    • 0035908923 scopus 로고    scopus 로고
    • High-throughput characterization of pattern formation in symmetric diblock copolymer films
    • Smith, A.P., Douglas, J.F., Meredith, J.C., Amis, E.J., and Karim, A. High-throughput characterization of pattern formation in symmetric diblock copolymer films. J Polym Sci B Polym Phys 39, 2141, 2001.
    • (2001) J Polym Sci B Polym Phys , vol.39 , pp. 2141
    • Smith, A.P.1    Douglas, J.F.2    Meredith, J.C.3    Amis, E.J.4    Karim, A.5
  • 98
    • 0344825275 scopus 로고    scopus 로고
    • High- throughput investigation of osteoblast response to polymer crystallinity: Influence of nanometer-scale roughness on proliferation
    • Washburn, N.R., Yamada, K.M., Simon, C.G., Kennedy, S.B., and Amis, E.J. High- throughput investigation of osteoblast response to polymer crystallinity: influence of nanometer-scale roughness on proliferation. Biomaterials 25, 1215, 2004.
    • (2004) Biomaterials , vol.25 , pp. 1215
    • Washburn, N.R.1    Yamada, K.M.2    Simon, C.G.3    Kennedy, S.B.4    Amis, E.J.5
  • 99
    • 23244435717 scopus 로고    scopus 로고
    • Combinatorial screening of cell proliferation on poly (L-lactic acid)/poly (D, L-lactic acid) blends
    • Simon, C.G., Jr., Eidelman, N., Kennedy, S.B., Sehgal, A., Khatri, C.A., and Washburn, N.R. Combinatorial screening of cell proliferation on poly (L-lactic acid)/poly (D, L-lactic acid) blends. Biomaterials 26, 6906, 2005.
    • (2005) Biomaterials , vol.26 , pp. 6906
    • Simon Jr., C.G.1    Eidelman, N.2    Kennedy, S.B.3    Sehgal, A.4    Khatri, C.A.5    Washburn, N.R.6
  • 100
    • 8644248184 scopus 로고    scopus 로고
    • Characterization of combinatorial polymer blend composition gradients by FTIR microspectroscopy
    • Eidelman, N., and Simon, C.G., Jr. Characterization of combinatorial polymer blend composition gradients by FTIR microspectroscopy. J Res Natl Inst Stand Technol 109, 219, 2004.
    • (2004) J Res Natl Inst Stand Technol , vol.109 , pp. 219
    • Eidelman, N.1    Simon Jr., C.G.2
  • 101
    • 0034248208 scopus 로고    scopus 로고
    • High-throughput measurement of polymer blend phase behavior
    • Meredith, J.C., Karim, A., and Amis, E.J. High-throughput measurement of polymer blend phase behavior. Macromolecules 33, 5760, 2000.
    • (2000) Macromolecules , vol.33 , pp. 5760
    • Meredith, J.C.1    Karim, A.2    Amis, E.J.3
  • 103
    • 13944257776 scopus 로고    scopus 로고
    • The use of temperature-composition combinatorial libraries to study the effects of biodegradable polymer blend surfaces on vascular cells
    • Sung, H.J., Su, J., Berglund, J.D., Russ, B.V., Meredith, J.C., and Galis, Z.S. The use of temperature-composition combinatorial libraries to study the effects of biodegradable polymer blend surfaces on vascular cells. Biomaterials 26, 4557, 2005.
    • (2005) Biomaterials , vol.26 , pp. 4557
    • Sung, H.J.1    Su, J.2    Berglund, J.D.3    Russ, B.V.4    Meredith, J.C.5    Galis, Z.S.6
  • 104
    • 0037462952 scopus 로고    scopus 로고
    • Combinatorial mapping of surface energy effects on diblock copolymer thin film ordering
    • Smith, A.P., Sehgal, A., Douglas, J.F., Karim, A., and Amis, E.J. Combinatorial mapping of surface energy effects on diblock copolymer thin film ordering. Macromol Rapid Commun 24, 131, 2003.
    • (2003) Macromol Rapid Commun , vol.24 , pp. 131
    • Smith, A.P.1    Sehgal, A.2    Douglas, J.F.3    Karim, A.4    Amis, E.J.5
  • 105
    • 1042281056 scopus 로고    scopus 로고
    • Assembly of nanoparticles using surface- grafted orthogonal polymer gradients
    • Bhat, R.R., Tomlinson, M.R., and Genzer, J. Assembly of nanoparticles using surface- grafted orthogonal polymer gradients. Macromol Rapid Commun 25, 270, 2004.
    • (2004) Macromol Rapid Commun , vol.25 , pp. 270
    • Bhat, R.R.1    Tomlinson, M.R.2    Genzer, J.3
  • 106
    • 0034498673 scopus 로고    scopus 로고
    • Combinatorial materials science for polymer thin-film dewetting
    • Meredith, J.C., Smith, A.P., Karim, A., and Amis, E.J. Combinatorial materials science for polymer thin-film dewetting. Macromolecules 33, 9747, 2000.
    • (2000) Macromolecules , vol.33 , pp. 9747
    • Meredith, J.C.1    Smith, A.P.2    Karim, A.3    Amis, E.J.4
  • 107
    • 0037462952 scopus 로고    scopus 로고
    • Combinatorial mapping of surface energy effects on diblock copolymer thin film ordering
    • Smith, A.P., Sehgal, A., Douglas, J.F., Karim, A., and Amis, E.J. Combinatorial mapping of surface energy effects on diblock copolymer thin film ordering. Macromol Rapid Commun 24, 131, 2003.
    • (2003) Macromol Rapid Commun , vol.24 , pp. 131
    • Smith, A.P.1    Sehgal, A.2    Douglas, J.F.3    Karim, A.4    Amis, E.J.5
  • 108
    • 0035941075 scopus 로고    scopus 로고
    • Taking cell-matrix adhesions to the third dimension
    • Cukierman, E., Pankov, R., Stevens, D.R., and Yamada, K.M. Taking cell-matrix adhesions to the third dimension. Science 294, 1708, 2001.
    • (2001) Science , vol.294 , pp. 1708
    • Cukierman, E.1    Pankov, R.2    Stevens, D.R.3    Yamada, K.M.4
  • 109
    • 54949097679 scopus 로고    scopus 로고
    • Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures
    • Gelain, F., Bottai, D., Vescovi, A., and Zhang, S. Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS ONE 1, e119, 2006.
    • (2006) PLoS ONE , vol.1
    • Gelain, F.1    Bottai, D.2    Vescovi, A.3    Zhang, S.4
  • 110
    • 33745713065 scopus 로고    scopus 로고
    • Characterization of functionally graded hydroxyapatite/titanium composite coatings plasma-sprayed on Ti alloys
    • Chen, C.C., Huang, T.H., Kao, C.T., and Ding, S.J. Characterization of functionally graded hydroxyapatite/titanium composite coatings plasma-sprayed on Ti alloys. J Biomed Mater Res B Appl Biomater 78, 146, 2006.
    • (2006) J Biomed Mater Res B Appl Biomater , vol.78 , pp. 146
    • Chen, C.C.1    Huang, T.H.2    Kao, C.T.3    Ding, S.J.4
  • 111
    • 34447285526 scopus 로고    scopus 로고
    • Strong, macroporous, and in situ-setting calcium phosphate cementlayered structures
    • Xu, H.H., Burguera, E.F., and Carey, L.E. Strong, macroporous, and in situ-setting calcium phosphate cementlayered structures. Biomaterials 28, 3786, 2007.
    • (2007) Biomaterials , vol.28 , pp. 3786
    • Xu, H.H.1    Burguera, E.F.2    Carey, L.E.3
  • 112
    • 36448970143 scopus 로고    scopus 로고
    • Fabrication of porous bioceramics with porosity gradients similar to the bimodal structure of cortical and cancellous bone
    • Hsu, Y.H., Turner, I.G., and Miles, A.W. Fabrication of porous bioceramics with porosity gradients similar to the bimodal structure of cortical and cancellous bone. J Mater Sci Mater Med 18, 2251, 2007.
    • (2007) J Mater Sci Mater Med , vol.18 , pp. 2251
    • Hsu, Y.H.1    Turner, I.G.2    Miles, A.W.3
  • 113
    • 2542612319 scopus 로고    scopus 로고
    • Design optimization of functionally graded dental implant
    • Hedia, H.S., and Mahmoud, N.A. Design optimization of functionally graded dental implant. Biomed Mater Eng 14, 133, 2004.
    • (2004) Biomed Mater Eng , vol.14 , pp. 133
    • Hedia, H.S.1    Mahmoud, N.A.2
  • 114
    • 0033134847 scopus 로고    scopus 로고
    • Preparation and characterization of bioactive monolayer and functionally graded coatings
    • Wang, M., Yang, X.Y., Khor, K.A., and Wang, Y. Preparation and characterization of bioactive monolayer and functionally graded coatings. J Mater Sci Mater Med 10, 269, 1999.
    • (1999) J Mater Sci Mater Med , vol.10 , pp. 269
    • Wang, M.1    Yang, X.Y.2    Khor, K.A.3    Wang, Y.4
  • 115
    • 0037695310 scopus 로고
    • Coating of implants
    • Gruner, H. Coating of implants. Chem Abstr 106, 55966g, 1987.
    • (1987) Chem Abstr , vol.106
    • Gruner, H.1
  • 117
    • 0034282196 scopus 로고    scopus 로고
    • Formation of bioactive functionally graded structure on Ti-6Al-4V alloy by chemical surface treatment
    • Kim, H.M., Takadama, H., Miyaji, F., Kokubo, T., Nishiguchi, S., and Nakamura, T. Formation of bioactive functionally graded structure on Ti-6Al-4V alloy by chemical surface treatment. J Mater Sci Mater Med 11, 555, 2000.
    • (2000) J Mater Sci Mater Med , vol.11 , pp. 555
    • Kim, H.M.1    Takadama, H.2    Miyaji, F.3    Kokubo, T.4    Nishiguchi, S.5    Nakamura, T.6
  • 118
    • 3442881332 scopus 로고    scopus 로고
    • Hard-tissue-engineered zirconia porous scaffolds with hydroxyapatite sol-gel and slurry coatings
    • Kim, H.W., Kim, H.E., and Knowles, J.C. Hard-tissue-engineered zirconia porous scaffolds with hydroxyapatite sol-gel and slurry coatings. J Biomed Mater Res 70, 270, 2004.
    • (2004) J Biomed Mater Res , vol.70 , pp. 270
    • Kim, H.W.1    Kim, H.E.2    Knowles, J.C.3
  • 119
    • 33747400946 scopus 로고    scopus 로고
    • Corrosion test, cell behavior test, and in vivo study of gradient TiO2 layers produced by compound electrochemical oxidation
    • Zhu, L., Ye, X., Tang, G., Zhao, N., Gong, Y., Zhao, Y., Zhao, J., and Zhang, X. Corrosion test, cell behavior test, and in vivo study of gradient TiO2 layers produced by compound electrochemical oxidation. J Biomed Mater Res A 78, 515, 2006.
    • (2006) J Biomed Mater Res A , vol.78 , pp. 515
    • Zhu, L.1    Ye, X.2    Tang, G.3    Zhao, N.4    Gong, Y.5    Zhao, Y.6    Zhao, J.7    Zhang, X.8
  • 121
    • 11844282688 scopus 로고    scopus 로고
    • Surface-gradient cross-linked polyethylene acetabular cups: Oxidation resistance and wear against smooth and rough femoral balls
    • Shen, F.W., and McKellop, H. Surface-gradient cross-linked polyethylene acetabular cups: oxidation resistance and wear against smooth and rough femoral balls. Clin Orthop Relat Res 430, 80, 2005.
    • (2005) Clin Orthop Relat Res , vol.430 , pp. 80
    • Shen, F.W.1    McKellop, H.2
  • 122
    • 0032945120 scopus 로고    scopus 로고
    • Synthesis and characterization of a novel UHMWPE interpenetrating polymer network
    • Beauregard, G.P., and James, S.P. Synthesis and characterization of a novel UHMWPE interpenetrating polymer network. Biomed Sci Instrum 35, 415, 1999.
    • (1999) Biomed Sci Instrum , vol.35 , pp. 415
    • Beauregard, G.P.1    James, S.P.2
  • 123
    • 0035094336 scopus 로고    scopus 로고
    • Titanium powder sintering for preparation of a porous functionally graded material destined for orthopaedic implants
    • Thieme, M., Wieters, K.P., Bergner, F., Scharnweber, D., Worch, H., Ndop, J., Kim, T.J., and Grill, W. Titanium powder sintering for preparation of a porous functionally graded material destined for orthopaedic implants. J Mater Sci Mater Med 12, 225, 2001.
    • (2001) J Mater Sci Mater Med , vol.12 , pp. 225
    • Thieme, M.1    Wieters, K.P.2    Bergner, F.3    Scharnweber, D.4    Worch, H.5    Ndop, J.6    Kim, T.J.7    Grill, W.8
  • 125
    • 0032911115 scopus 로고    scopus 로고
    • Porosity control of hydroxyapatite implants
    • Vaz, L., Lopes, A.B., and Almeida, M. Porosity control of hydroxyapatite implants. J Mater Sci Mater Med 10, 239, 1999.
    • (1999) J Mater Sci Mater Med , vol.10 , pp. 239
    • Vaz, L.1    Lopes, A.B.2    Almeida, M.3
  • 126
    • 0036319948 scopus 로고    scopus 로고
    • Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure
    • Werner, J., Linner-Krcmar, B., Friess, W., and Greil, P. Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure. Biomaterials 23, 4285, 2002.
    • (2002) Biomaterials , vol.23 , pp. 4285
    • Werner, J.1    Linner-Krcmar, B.2    Friess, W.3    Greil, P.4
  • 127
    • 33750184238 scopus 로고    scopus 로고
    • Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplasty
    • Eufinger, H., Rasche, C., Lehmbrock, J., Wehmoller, M., Weihe, S., Schmitz, I., Schiller, C., and Epple, M. Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplasty. Biomaterials 28, 475, 2007.
    • (2007) Biomaterials , vol.28 , pp. 475
    • Eufinger, H.1    Rasche, C.2    Lehmbrock, J.3    Wehmoller, M.4    Weihe, S.5    Schmitz, I.6    Schiller, C.7    Epple, M.8
  • 128
    • 0035789452 scopus 로고    scopus 로고
    • Ceramic-polymer functionally gradient material: A novel disc prosthesis
    • Boughton, P., Ferris, D., and Ruys, A.J. Ceramic-polymer functionally gradient material: a novel disc prosthesis. Ceram Eng Sci Proc 22, 593, 2001.
    • (2001) Ceram Eng Sci Proc , vol.22 , pp. 593
    • Boughton, P.1    Ferris, D.2    Ruys, A.J.3
  • 129
    • 0036968070 scopus 로고    scopus 로고
    • Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material
    • Bogdanski, D., Köller, M., Müller, D., Muhr, G., Bram, M., Buchkremer, H.P., Stöver, D., Choi, J., and Epple, M. Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material. Biomaterials 23, 4549, 2002.
    • (2002) Biomaterials , vol.23 , pp. 4549
    • Bogdanski, D.1    Köller, M.2    Müller, D.3    Muhr, G.4    Bram, M.5    Buchkremer, H.P.6    Stöver, D.7    Choi, J.8    Epple, M.9
  • 130
    • 1642464933 scopus 로고    scopus 로고
    • Biocompatibility of materials and development to functionally graded implant for biomedical application
    • Watari, F., Yokoyama, A., Omori, M., Hirai, T., Kondo, H., Uo, M., and Kawasaki, T. Biocompatibility of materials and development to functionally graded implant for biomedical application. Compos Sci Technol 64, 893, 2004.
    • (2004) Compos Sci Technol , vol.64 , pp. 893
    • Watari, F.1    Yokoyama, A.2    Omori, M.3    Hirai, T.4    Kondo, H.5    Uo, M.6    Kawasaki, T.7
  • 131
    • 34447506068 scopus 로고    scopus 로고
    • A three-dimensional finite element study on the biomechanical behavior of an FGBM dental implant in surrounding bone
    • Yang, J., and Xiang, H.J. A three-dimensional finite element study on the biomechanical behavior of an FGBM dental implant in surrounding bone. J Biomech 40, 2377, 2007.
    • (2007) J Biomech , vol.40 , pp. 2377
    • Yang, J.1    Xiang, H.J.2
  • 132
    • 0033752170 scopus 로고    scopus 로고
    • Simulation and investigation of pore size graded titania layers during sintering
    • Moritz, T., Riedel, H., Werner, G., and Tomandl, G. Simulation and investigation of pore size graded titania layers during sintering. J Mater Sci 35, 2235, 2000.
    • (2000) J Mater Sci , vol.35 , pp. 2235
    • Moritz, T.1    Riedel, H.2    Werner, G.3    Tomandl, G.4
  • 133
    • 0029456790 scopus 로고    scopus 로고
    • Mortensen, A., and Suresh, S. Functionally graded metals and metal-ceramic composites. Part 1. Processing. Int Mater Rev 40, 239, 1995.
    • Mortensen, A., and Suresh, S. Functionally graded metals and metal-ceramic composites. Part 1. Processing. Int Mater Rev 40, 239, 1995.
  • 135
    • 0035950105 scopus 로고    scopus 로고
    • Morphogen gradient interpretation
    • Gurdon, J.B., and Bourillot, P.Y. Morphogen gradient interpretation. Nature 413, 797, 2001.
    • (2001) Nature , vol.413 , pp. 797
    • Gurdon, J.B.1    Bourillot, P.Y.2
  • 137
    • 0029959555 scopus 로고    scopus 로고
    • The molecular biology of axon guidance
    • Tessier-Lavigne, M. The molecular biology of axon guidance. Science 274, 1123, 1996.
    • (1996) Science , vol.274 , pp. 1123
    • Tessier-Lavigne, M.1
  • 138
    • 0033617576 scopus 로고    scopus 로고
    • A cell's sense of direction
    • Parent, C.A., and Devreotes, P.N. A cell's sense of direction. Science 284, 765, 1999.
    • (1999) Science , vol.284 , pp. 765
    • Parent, C.A.1    Devreotes, P.N.2
  • 139
    • 33845927527 scopus 로고    scopus 로고
    • Tissue engineering: The next generation
    • Vunjak-Novakovic, G., and Kaplan, D.L. Tissue engineering: the next generation. Tissue Eng 12, 3261, 2006.
    • (2006) Tissue Eng , vol.12 , pp. 3261
    • Vunjak-Novakovic, G.1    Kaplan, D.L.2
  • 141
    • 0042626603 scopus 로고    scopus 로고
    • Polymeric growth factor delivery strategies for tissue engineering
    • Chen, R.R., and Mooney, D.J. Polymeric growth factor delivery strategies for tissue engineering. Pharm Res 20, 1103, 2003.
    • (2003) Pharm Res , vol.20 , pp. 1103
    • Chen, R.R.1    Mooney, D.J.2
  • 143
    • 0025734184 scopus 로고
    • Adhesive recognition sequences
    • Yamada, K.M. Adhesive recognition sequences. J Biol Chem 266, 12809, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 12809
    • Yamada, K.M.1
  • 144
    • 0041559949 scopus 로고    scopus 로고
    • RGD modified polymers: Biomaterials for stimulated cell adhesion and beyond
    • Hersel, U., Dahmen, C., and Kessler, H. RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24, 4385, 2003.
    • (2003) Biomaterials , vol.24 , pp. 4385
    • Hersel, U.1    Dahmen, C.2    Kessler, H.3
  • 145
    • 33745964571 scopus 로고    scopus 로고
    • Anisotropic scaffolds facilitate enhanced neurite extension in vitro
    • Dodla, M.C., and Bellamkonda, R.V. Anisotropic scaffolds facilitate enhanced neurite extension in vitro. J Biomed Mater Res A 78, 213, 2006.
    • (2006) J Biomed Mater Res A , vol.78 , pp. 213
    • Dodla, M.C.1    Bellamkonda, R.V.2
  • 146
    • 0030014477 scopus 로고    scopus 로고
    • The behavior of optic axons on substrate gradients of retinal basal lamina proteins and merosin
    • Halfter, W. The behavior of optic axons on substrate gradients of retinal basal lamina proteins and merosin. J Neurosci 16, 4389, 1996.
    • (1996) J Neurosci , vol.16 , pp. 4389
    • Halfter, W.1
  • 149
    • 33645509696 scopus 로고    scopus 로고
    • Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds
    • Moore, K., MacSween, M., and Shoichet, M. Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds. Tissue Eng 12, 267, 2006.
    • (2006) Tissue Eng , vol.12 , pp. 267
    • Moore, K.1    MacSween, M.2    Shoichet, M.3
  • 150
    • 0035925694 scopus 로고    scopus 로고
    • Defining the concentration gradient of nerve growth factor for guided neurite outgrowth
    • Cao, X., and Shoichet, M.S. Defining the concentration gradient of nerve growth factor for guided neurite outgrowth. Neuroscience 103, 831, 2001.
    • (2001) Neuroscience , vol.103 , pp. 831
    • Cao, X.1    Shoichet, M.S.2
  • 151
    • 0242403192 scopus 로고    scopus 로고
    • Investigating the synergistic effect of combined neurotrophic factor concentration gradients to guide axonal growth
    • Cao, X., and Shoichet, M.S. Investigating the synergistic effect of combined neurotrophic factor concentration gradients to guide axonal growth. Neuroscience 122, 381, 2003.
    • (2003) Neuroscience , vol.122 , pp. 381
    • Cao, X.1    Shoichet, M.S.2
  • 152
    • 1942485769 scopus 로고    scopus 로고
    • Immobilized concentration gradients of nerve growth factor guide neurite outgrowth
    • Kapur, T.A., and Shoichet, M.S. Immobilized concentration gradients of nerve growth factor guide neurite outgrowth. J Biomed Mater Res 68, 235, 2004.
    • (2004) J Biomed Mater Res , vol.68 , pp. 235
    • Kapur, T.A.1    Shoichet, M.S.2
  • 153
    • 35349005760 scopus 로고    scopus 로고
    • Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps
    • Dodla, M.C., and Bellamkonda, R.V. Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. Biomaterials 29, 33, 2008.
    • (2008) Biomaterials , vol.29 , pp. 33
    • Dodla, M.C.1    Bellamkonda, R.V.2
  • 154
    • 8444223159 scopus 로고    scopus 로고
    • Cellular alignment by grafted adhesion peptide surface density gradients
    • Kang, C.E., Gemeinhart, E.J., and Gemeinhart, R.A. Cellular alignment by grafted adhesion peptide surface density gradients. J Biomed Mater Res A 71, 403, 2004.
    • (2004) J Biomed Mater Res A , vol.71 , pp. 403
    • Kang, C.E.1    Gemeinhart, E.J.2    Gemeinhart, R.A.3
  • 155
    • 10644257537 scopus 로고    scopus 로고
    • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration
    • DeLong, S.A., Moon, J.J., and West, J.L. Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. Biomaterials 26, 3227, 2005.
    • (2005) Biomaterials , vol.26 , pp. 3227
    • DeLong, S.A.1    Moon, J.J.2    West, J.L.3
  • 156
    • 28444495861 scopus 로고    scopus 로고
    • Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration
    • DeLong, S.A., Gobin, A.S., and West, J.L. Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration. J Control Release 109, 139, 2005.
    • (2005) J Control Release , vol.109 , pp. 139
    • DeLong, S.A.1    Gobin, A.S.2    West, J.L.3
  • 157
    • 0033558806 scopus 로고    scopus 로고
    • A fibrin or collagen gel assay for tissue cell chemotaxis: Assessment of fibroblast chemotaxis to GRGDSP
    • Knapp, D.M., Helou, E.F., and Tranquillo, R.T. A fibrin or collagen gel assay for tissue cell chemotaxis: assessment of fibroblast chemotaxis to GRGDSP. Exp Cell Res 247, 543, 1999.
    • (1999) Exp Cell Res , vol.247 , pp. 543
    • Knapp, D.M.1    Helou, E.F.2    Tranquillo, R.T.3
  • 158
    • 0034904719 scopus 로고    scopus 로고
    • Gradient micropattern immobilization of EGF to investigate the effect of artificial juxtacrine stimulation
    • Chen, G., and Ito, Y. Gradient micropattern immobilization of EGF to investigate the effect of artificial juxtacrine stimulation. Biomaterials 22, 2453, 2001.
    • (2001) Biomaterials , vol.22 , pp. 2453
    • Chen, G.1    Ito, Y.2
  • 159
    • 0343841187 scopus 로고
    • The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes
    • Boyden, S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med 115, 453, 1962.
    • (1962) J Exp Med , vol.115 , pp. 453
    • Boyden, S.1
  • 160
    • 0016712881 scopus 로고
    • Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes
    • Nelson, R.D. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol 115, 1650, 1975.
    • (1975) J Immunol , vol.115 , pp. 1650
    • Nelson, R.D.1
  • 161
    • 0015582757 scopus 로고
    • Leukocyte locomotion and chemotaxis: New methods for evaluation, and demonstration of a cell-derived chemotactic factor
    • Zigmond, S.H., and Hirsch, J.G. Leukocyte locomotion and chemotaxis: new methods for evaluation, and demonstration of a cell-derived chemotactic factor. J Exp Med 137, 387, 1973.
    • (1973) J Exp Med , vol.137 , pp. 387
    • Zigmond, S.H.1    Hirsch, J.G.2
  • 162
    • 0025788971 scopus 로고
    • A new direct-viewing chemotaxis chamber
    • Zicha, D., Dunn, G.A., and Brown, A.F. A new direct-viewing chemotaxis chamber. J Cell Sci 99, 769, 1991.
    • (1991) J Cell Sci , vol.99 , pp. 769
    • Zicha, D.1    Dunn, G.A.2    Brown, A.F.3
  • 163
    • 0024635815 scopus 로고
    • Quantitative analysis of cell motility and chemotaxis in Dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients
    • Fisher, P.R. Quantitative analysis of cell motility and chemotaxis in Dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients. J Cell Biol 108, 973, 1989.
    • (1989) J Cell Biol , vol.108 , pp. 973
    • Fisher, P.R.1
  • 167
    • 0028908051 scopus 로고
    • Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay
    • Moghe, P.V., Nelson, R.D., and Tranquillo, R.T. Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay. J Immunol Methods 180, 193, 1995.
    • (1995) J Immunol Methods , vol.180 , pp. 193
    • Moghe, P.V.1    Nelson, R.D.2    Tranquillo, R.T.3
  • 169
    • 0035866594 scopus 로고    scopus 로고
    • Generation of gradients having complex shapes using microfluidic networks
    • Dertinger, S.K.W., Chiu, D.T., Jeon, N.L., and Whitesides, G.M. Generation of gradients having complex shapes using microfluidic networks. Anal Chem 73, 1240, 2001.
    • (2001) Anal Chem , vol.73 , pp. 1240
    • Dertinger, S.K.W.1    Chiu, D.T.2    Jeon, N.L.3    Whitesides, G.M.4
  • 170
    • 33646420095 scopus 로고    scopus 로고
    • Cell migration and polarity on microfabricated gradients of extracellular matrix proteins
    • Gunawan, R.C., Silvestre, J., Gaskins, H.R., Kenis, P.J.A., and Leckband, D.E. Cell migration and polarity on microfabricated gradients of extracellular matrix proteins. Langmuir 22, 4250, 2006.
    • (2006) Langmuir , vol.22 , pp. 4250
    • Gunawan, R.C.1    Silvestre, J.2    Gaskins, H.R.3    Kenis, P.J.A.4    Leckband, D.E.5
  • 171
    • 20844440162 scopus 로고    scopus 로고
    • Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator
    • Walker, G.M., Sai, J., Richmond, A., Stremler, M., Chung, C.Y., and Wikswo, J.P. Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator. Lab Chip 5, 611, 2005.
    • (2005) Lab Chip , vol.5 , pp. 611
    • Walker, G.M.1    Sai, J.2    Richmond, A.3    Stremler, M.4    Chung, C.Y.5    Wikswo, J.P.6
  • 173
    • 56749184607 scopus 로고    scopus 로고
    • Microsphere-based seamless scaffolds containing macroscopic gradients of encapsulated bioactive factors for tissue engineering
    • Epub ahead of print, DOI: 10.1089/ten.tec.2008.0167
    • Singh, M., Morris, C.P., Ellis, R., Detamore, M.S., and Berkland, C. Microsphere-based seamless scaffolds containing macroscopic gradients of encapsulated bioactive factors for tissue engineering. Tissue Eng, Part C: Methods, 2008 [Epub ahead of print]; DOI: 10.1089/ten.tec.2008.0167.
    • (2008) Tissue Eng, Part C: Methods
    • Singh, M.1    Morris, C.P.2    Ellis, R.3    Detamore, M.S.4    Berkland, C.5
  • 174
    • 33646053836 scopus 로고    scopus 로고
    • Covalently immobilized enzyme gradients within three- dimensional porous scaffolds
    • Vepari, C.P., and Kaplan, D.L. Covalently immobilized enzyme gradients within three- dimensional porous scaffolds. Biotechnol Bioeng 93, 1130, 2006.
    • (2006) Biotechnol Bioeng , vol.93 , pp. 1130
    • Vepari, C.P.1    Kaplan, D.L.2
  • 176
    • 34447260532 scopus 로고    scopus 로고
    • Inkjet printing of macromolecules on hydrogels to steer neural stem cell differentiation
    • Ilkhanizadeh, S., Teixeira, A.I., and Hermanson, O. Inkjet printing of macromolecules on hydrogels to steer neural stem cell differentiation. Biomaterials 28, 3936, 2007.
    • (2007) Biomaterials , vol.28 , pp. 3936
    • Ilkhanizadeh, S.1    Teixeira, A.I.2    Hermanson, O.3
  • 177
    • 33646040094 scopus 로고    scopus 로고
    • Generation and characterization of photopolymerized polymer brush gradients
    • Harris, B.P., and Metters, A.T. Generation and characterization of photopolymerized polymer brush gradients. Macromolecules 39, 2764, 2006.
    • (2006) Macromolecules , vol.39 , pp. 2764
    • Harris, B.P.1    Metters, A.T.2
  • 178
    • 9644268186 scopus 로고    scopus 로고
    • Heterogeneous nanomechanical properties of superficial and zonal regions of articular cartilage of the rabbit proximal radius condyle by atomic force microscopy
    • Tomkoria, S., Patel, R.V., and Mao, J.J. Heterogeneous nanomechanical properties of superficial and zonal regions of articular cartilage of the rabbit proximal radius condyle by atomic force microscopy. Med Eng Phys 26, 815, 2004.
    • (2004) Med Eng Phys , vol.26 , pp. 815
    • Tomkoria, S.1    Patel, R.V.2    Mao, J.J.3
  • 180
    • 0035205165 scopus 로고    scopus 로고
    • Mechanical properties of the dentinoenamel junction: AFM studies of nanohardness, elastic modulus, and fracture
    • Marshall, G.W., Balooch, M., Gallagher, R.R., Gansky, S.A., and Marshall, S.J. Mechanical properties of the dentinoenamel junction: AFM studies of nanohardness, elastic modulus, and fracture. J Biomed Mater Res 54, 87, 2001.
    • (2001) J Biomed Mater Res , vol.54 , pp. 87
    • Marshall, G.W.1    Balooch, M.2    Gallagher, R.R.3    Gansky, S.A.4    Marshall, S.J.5
  • 181
    • 0033922963 scopus 로고    scopus 로고
    • Patterning the endoderm: The importance of neighbours
    • Horb, M.E. Patterning the endoderm: the importance of neighbours. BioEssays 22, 599, 2000.
    • (2000) BioEssays , vol.22 , pp. 599
    • Horb, M.E.1
  • 182
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry, C.E., and Keller, G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132, 661, 2008.
    • (2008) Cell , vol.132 , pp. 661
    • Murry, C.E.1    Keller, G.2
  • 183
    • 0036150574 scopus 로고    scopus 로고
    • Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells
    • Gerstenfeld, L.C., Cruceta, J., Shea, C.M., Sampath, K., Barnes, G.L., and Einhorn, T.A. Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells. J Bone Miner Res 17, 221, 2002.
    • (2002) J Bone Miner Res , vol.17 , pp. 221
    • Gerstenfeld, L.C.1    Cruceta, J.2    Shea, C.M.3    Sampath, K.4    Barnes, G.L.5    Einhorn, T.A.6
  • 184
    • 0038581169 scopus 로고    scopus 로고
    • Changing neighbours, changing behaviour: Cell adhesion molecule-mediated signalling during tumour progression
    • Focus, W., and Contact, N.P.G. Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression. EMBO J 22, 2318, 2003.
    • (2003) EMBO J , vol.22 , pp. 2318
    • Focus, W.1    Contact, N.P.G.2
  • 186
    • 38349108489 scopus 로고    scopus 로고
    • Sequential release of bioactive IGF-I and TGF-β1 from PLGA microsphere-based scaffolds
    • Jaklenec, A., Hinckfuss, A., Bilgen, B., Ciombor, D.M., Aaron, R., and Mathiowitz, E. Sequential release of bioactive IGF-I and TGF-β1 from PLGA microsphere-based scaffolds. Biomaterials 29, 1518, 2008.
    • (2008) Biomaterials , vol.29 , pp. 1518
    • Jaklenec, A.1    Hinckfuss, A.2    Bilgen, B.3    Ciombor, D.M.4    Aaron, R.5    Mathiowitz, E.6


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