A systems model for immune cell interactions unravels the mechanism of inflammation in human skin

PLoS Computational Biology

Volumn 6, Issue 12, 2010, Pages

  Valeyev, Najl V ^a,d   Hundhausen, Christian ^a   Umezawa, Yoshinori ^a   Kotov, Nikolay V ^b   Williams, Gareth ^c   Clop, Alex ^c   Ainali, Crysanthi ^a,c   Ouzounis, Christos ^c,e   Tsoka, Sophia ^c   Nestle, Frank O ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KAZAN FEDERAL UNIVERSITY   (Russian Federation)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF KENT   (United Kingdom)

^e INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; PATHOLOGY; REACTION RATES;

CELL INTERACTION; CELL POPULATIONS; CYTOKINE PRODUCTION; CYTOKINES; DISEASE PHENOTYPES; HUMAN SKIN; IMMUNE CELLS; INFLAMMATORY REACTION; PRODUCTION RATES; SYSTEM MODELS;

IMMUNE SYSTEM;

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ARTICLE; CELL FUNCTION; CELL INTERACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOPATHOLOGY; LYMPHOCYTE SUBPOPULATION; MATHEMATICAL MODEL; PHENOTYPE; PROTEIN BLOOD LEVEL; PSORIASIS; TH1 CELL; TH2 CELL; BIOLOGICAL MODEL; CYTOCHEMISTRY; DOSE RESPONSE; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE; METABOLISM; METHODOLOGY; SIGNAL TRANSDUCTION; SKIN; SYSTEMS BIOLOGY;

CYTOKINES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HISTOCYTOCHEMISTRY; HOMEOSTASIS; HUMANS; INFLAMMATION; LEUKOCYTES; MODELS, BIOLOGICAL; PHENOTYPE; PSORIASIS; SIGNAL TRANSDUCTION; SKIN; SYSTEMS BIOLOGY;

EID: 78651250747     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001024     Document Type: Article

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