Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea

Brain Research

Volumn 1368, Issue , 2011, Pages 231-238

  Da Silva, Ana Quenia Gomes ^a,b   Fontes, Marco Antônio Peliky ^a   Kanagy, Nancy Lapp ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin (1 7); Hypertension; Intermittent hypoxia; Renin angiotensin system; Sympathetic activity

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; LOSARTAN; MUSCIMOL; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ZD 7155;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; HYPERTENSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SLEEP APNEA SYNDROME; TELEMETRY;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN II TYPE 2 RECEPTOR BLOCKERS; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; HYPERTENSION; IMIDAZOLES; LOSARTAN; MALE; MICROINJECTIONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PEPTIDE FRAGMENTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SLEEP APNEA SYNDROMES;

RATTUS;

EID: 78651104672     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.10.087     Document Type: Article

References (62)

1. K.J. Allahdadi, B.R. Walker, and N.L. Kanagy Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension Hypertension 45 2005 705 709
2. A.M. Allen Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone Hypertension 39 2002 275 280
3. A.M. Allen, I. Moeller, T.A. Jenkins, J. Zhuo, G.P. Aldred, S.Y. Chai, and F.A. Mendelsohn Angiotensin receptors in the nervous system Brain Res. Bull. 47 1998 17 28
4. P. Ambuhl, D. Felix, H. Imboden, M.C. Khosla, and C.M. Ferrario Effects of angiotensin analogues and angiotensin receptor antagonists on paraventricular neurones Regul. Pept. 38 1992 111 120
5. P. Ambuhl, D. Felix, and M.C. Khosla [7-D-ALA]-angiotensin-(1-7): selective antagonism of angiotensin-(1-7) in the rat paraventricular nucleus Brain Res. Bull. 35 1994 289 291
6. E. Badoer Hypothalamic paraventricular nucleus and cardiovascular regulation Clin. Exp. Pharmacol. Physiol. 28 2001 95 99
7. L.K. Becker, G.M. Etelvino, T. Walther, R.A. Santos, and M.J. Campagnole-Santos Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain Am. J. Physiol. Heart Circ. Physiol. 293 2007 H1416 H1424
8. M.L. Blair, D. Piekut, A. Want, and J.A. Olschowka Role of the hypothalamic paraventricular nucleus in cardiovascular regulation Clin. Exp. Pharmacol. Physiol. 23 1996 161 165
9. C.H. Block, R.A. Santos, K.B. Brosnihan, and C.M. Ferrario Immunocytochemical localization of angiotensin-(1-7) in the rat forebrain Peptides 9 1988 1395 1401
10. V.A. Braga, R.N. Soriano, and B.H. Machado Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia Exp. Physiol. 91 2006 1025 1031
11. M.J. Cato, and G.M. Toney Angiotensin II excites paraventricular nucleus neurons that innervate the rostral ventrolateral medulla: an in vitro patch-clamp study in brain slices J. Neurophysiol. 93 2005 403 413
12. Q.H. Chen, and G.M. Toney AT(1) receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation Am. J. Physiol. 281 2001 R1844 R1853
13. Q.H. Chen, and G.M. Toney Responses to GABA-A receptor blockade in the hypothalamic PVN are attenuated by local AT1 receptor antagonism Am. J. Physiol. 285 2003 R1231 R1239
14. Q.H. Chen, J.R. Haywood, and G.M. Toney Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptors Hypertension 42 2003 725 731
15. J.C. Cruz, L.G. Bonagamba, B.H. Machado, V.C. Biancardi, and J.E. Stern Intermittent activation of peripheral chemoreceptors in awake rats induces Fos expression in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus Neuroscience 157 2008 463 472
16. M.J. Cutler, N.M. Swift, D.M. Keller, W.L. Wasmund, and M.L. Smith Hypoxia-mediated prolonged elevation of sympathetic nerve activity after periods of intermittent hypoxic apnea J. Appl. Physiol. 96 2004 754 761
17. R.A. Dampney Functional organization of central pathways regulating the cardiovascular system Physiol. Rev. 74 1994 323 364
18. R.A. Dampney, M.A. Fontes, Y. Hirooka, J. Horiuchi, P.D. Potts, and T. Tagawa Role of angiotensin II receptors in the regulation of vasomotor neurons in the ventrolateral medulla Clin. Exp. Pharmacol. Physiol. 29 2002 467 472
19. R.A. Dampney, P.S. Tan, M.J. Sheriff, M.A. Fontes, and J. Horiuchi Cardiovascular effects of angiotensin II in the rostral ventrolateral medulla: the push-pull hypothesis Curr. Hypertens. Rep. 9 2007 222 227
20. C. Decavel, and A.N. Van den Pol GABA: a dominant neurotransmitter in the hypothalamus J. Comp. Neurol. 302 1990 1019 1037
21. T.E. Dick, Y.H. Hsieh, N. Wang, and N. Prabhakar Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat Exp. Physiol. 92 2007 87 97
22. M. Egli, J.P. Laurent, R. Mosimann, D. Felix, and H. Imboden Morphological and immunocytochemical characterization of electrophysiologically investigated neurons in the PVN of the rat J. Neurosci. Meth. 95 2000 145 150
23. D. Felix, M.C. Khosla, K.L. Barnes, H. Imboden, B. Montani, and C.M. Ferrario Neurophysiological responses to angiotensin-(1-7) Hypertension 17 1991 1111 1114
24. E.C. Fletcher Invited review: physiological consequences of intermittent hypoxia: systemic blood pressure J. Appl. Physiol. 90 2001 1600 1605
25. E.C. Fletcher Sympathetic over activity in the etiology of hypertension of obstructive sleep apnea Sleep 26 2003 15 19
26. E.C. Fletcher, J. Lesske, J. Culman, C.C. Miller, and T. Unger Sympathetic denervation blocks blood pressure elevation in episodic hypoxia Hypertension 20 1992 612 619
27. E.C. Fletcher, J. Lesske, W. Qian, C.C. Miller III, and T. Unger Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats Hypertension 19 1992 555 561
28. E.C. Fletcher, G. Bao, and R. Li Renin activity and blood pressure in response to chronic episodic hypoxia Hypertension 34 1999 309 314 (Pubitemid 29409233)
29. H.E. Greenberg, A. Sica, D. Batson, and S.M. Scharf Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia J. Appl. Physiol. 86 1999 298 305
30. C. Hocht, J.A. Opezzo, M.M. Gironacci, C. Pena, and C.A. Taira Hypothalamic cardiovascular effects of angiotensin-(1-7) in spontaneously hypertensive rats Regul. Pept. 135 2006 39 44
31. T. Horn, P.M. Smith, B.E. McLaughlin, L. Bauce, G.S. Marks, Q.J. Pittman, and A.V. Ferguson Nitric oxide actions in paraventricular nucleus: cardiovascular and neurochemical implications Am. J. Physiol. 266 1994 R306 R313
32. H. Kannan, Y. Hayashida, and H. Yamashita Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats Am. J. Physiol. 256 1989 R1325 R1330
33. T. Kara, K. Narkiewicz, and V.K. Somers Chemoreflexes-physiology and clinical implications Acta Physiol. Scand. 177 2003 377 384
34. M.J. McKinley, A.L. Albiston, A.M. Allen, M.L. Mathai, C.N. May, R.M. McAllen, B.J. Oldfield, F.A. Mendelsohn, and S.Y. Chai The brain renin-angiotensin system: location and physiological roles Int. J. Biochem. Cell Biol. 35 2003 901 918
35. B.J. Morgan, D.C. Crabtree, M. Palta, and J.B. Skatrud Combined hypoxia and hypercapnia evokes long-lasting sympathetic activation in humans J. Appl. Physiol. 79 1995 205 213
36. K. Narkiewicz, and V.K. Somers Sympathetic nerve activity in obstructive sleep apnoea Acta Physiol. Scand. 177 2003 385 390
37. K. Narkiewicz, C.A. Pesek, M. Kato, B.G. Phillips, D.E. Davison, and V.K. Somers Baroreflex control of sympathetic nerve activity and heart rate in obstructive sleep apnea Hypertension 32 1998 1039 1043
38. M.V. Olivan, L.G. Bonagamba, and B.H. Machado Involvement of the paraventricular nucleus of the hypothalamus in the pressor response to chemoreflex activation in awake rats Brain Res. 895 2001 167 172
39. Y.J. Peng, J.L. Overholt, D. Kline, G.K. Kumar, and N.R. Prabhakar Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas Proc. Natl Acad. Sci. USA 100 2003 10073 10078
40. N.R. Prabhakar, Y.J. Peng, F.J. Jacono, G.K. Kumar, and T.E. Dick Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes Clin. Exp. Pharmacol. Physiol. 32 2005 447 449
41. N.R. Prabhakar, T.E. Dick, J. Nanduri, and G.K. Kumar Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia Exp. Physiol. 92 2007 39 44
42. M.K. Reddy, K.P. Patel, and H.D. Schultz Differential role of the paraventricular nucleus of the hypothalamus in modulating the sympathoexcitatory component of peripheral and central chemoreflexes Am. J. Physiol. 289 2005 R789 R797
43. S.G. Shelat, L.P. Reagan, J.L. King, S.J. Fluharty, and L.M. Flanagan-Cato Analysis of angiotensin type 2 receptors in vasopressinergic neurons and pituitary in the rat Regul. Pept. 73 1998 103 112
44. M.J. Sheriff, M.A. Fontes, S. Killinger, J. Horiuchi, and R.A. Dampney Blockade of AT1 receptors in the rostral ventrolateral medulla increases sympathetic activity under hypoxic conditions Am. J. Physiol. 290 2006 R733 R740
45. A.L. Sica, H.E. Greenberg, D.A. Ruggiero, and S.M. Scharf Chronic-intermittent hypoxia: a model of sympathetic activation in the rat Respir. Physiol. 121 2000 173 184
46. A.Q. Silva, R.A. Santos, and M.A. Fontes Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone Hypertension 46 2005 341 348
47. M.L. Smith, O.N. Niedermaier, S.M. Hardy, M.J. Decker, and K.P. Strohl Role of hypoxemia in sleep apnea-induced sympathoexcitation J. Auton. Nerv. Syst. 56 1996 184 190
48. J.B. Snow, V. Kitzis, C.E. Norton, S.N. Torres, K.D. Johnson, N.L. Kanagy, B.R. Walker, and T.C. Resta Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity J. Appl. Physiol. 104 2008 110 118
49. J.E. Stern, Y. Li, and W. Zhang Nitric oxide: a local signalling molecule controlling the activity of pre-autonomic neurones in the paraventricular nucleus of the hypothalamus Acta Physiol. Scand. 177 2003 37 42
50. M. Stoll, and T. Unger Angiotensin and its AT2 receptor: new insights into an old system Regul. Pept. 99 2001 175 182
51. T. Tagawa, and R.A. Dampney AT(1) receptors mediate excitatory inputs to rostral ventrolateral medulla pressor neurons from hypothalamus Hypertension 34 1999 1301 1307
52. S.J. Veerasingham, and M.K. Raizada Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives Br. J. Pharmacol. 139 2003 191 202
53. O. Von Bohlen und Halbach, T. Walther, M. Bader, and D. Albrecht Interactions between Mas and the angiotensin AT1 receptor in the amygdala J. Neurophysiol. 83 2000 2012 2021
54. J.W. Weiss, M.D. Liu, and J. Huang Physiological basis for a causal relationship of obstructive sleep apnoea to hypertension Exp. Physiol. 92 2007 21 26
55. R. Wolk, A.S. Shamsuzzaman, and V.K. Somers Obesity, sleep apnea, and hypertension Hypertension 42 2003 1067 1074
56. J.W. Wright, and J.W. Harding Brain angiotensin receptor subtypes in the control of physiological and behavioral responses Neurosci. Biobehav. Rev. 18 1994 21 53
57. A. Xie, J.B. Skatrud, D.S. Puleo, and B.J. Morgan Exposure to hypoxia produces long-lasting sympathetic activation in humans J. Appl. Physiol. 91 2001 1555 1562
58. K. Zhang, Y.F. Li, and K.P. Patel Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure Am. J. Physiol. Heart Circ. Physiol. 281 2001 H995 H1004
59. K. Zhang, Y.F. Li, and K.P. Patel Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure Am. J. Physiol. 282 2002 R1006 R1015
60. G.Q. Zhu, K.P. Patel, I.H. Zucker, and W. Wang Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats Am. J. Physiol. Heart Circ. Physiol. 282 2002 H2039 H2045
61. I.H. Zucker Brain angiotensin II: new insights into its role in sympathetic regulation Circ. Res. 90 2002 503 505
62. I.H. Zucker, H.D. Schultz, Y.F. Li, Y. Wang, W. Wang, and K.P. Patel The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide Prog. Biophys. Mol. Biol. 84 2004 217 232