Responses to GABA-A receptor blockade in the hypothalamic PVN are attenuated by local AT1 receptor antagonism

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 285, Issue 5 54-5, 2003, Pages

  Chen, Qing Hui ^a   Toney, Glenn M ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Angiotensin II; Arterial pressure; Bicuculline methobromide; Paraventricular nucleus; Sympathetic nerve activity

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 2 ETHYL 5,7 DIMETHYL 3 [4 [2 (2H TETRAZOL 5 YL)PHENYL]BENZYL]IMIDAZO[4,5 B]PYRIDINE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; BICUCULLINE METHOBROMIDE; LOSARTAN;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; HEART RATE; KIDNEY NERVE; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; SYMPATHETIC NERVE; SYMPATHETIC TONE; TACHYCARDIA;

EID: 0142095227     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00028.2003     Document Type: Article

References (40)

1. Allen AM. Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone. Hypertension 39: 275-280, 2002.
2. Bains JS and Ferguson AV. Nitric oxide regulates NMDA driven GABAergic inputs to type I neurons of the rat paraventricular nucleus. J Physiol 499: 733-746, 1997.
3. Boudaba C, Szabo K, and Tasker JG. Physiological mapping of local inhibitory inputs to the hypothalamic paraventricular nucleus. J Neurosci 16: 7151-7160, 1996.
4. Chang RS, Siegl PK, Clineschmidt BV, Mantlo NB, Chakravarty PK, Greenlee WJ, Patchett AA, and Lotti VJ. In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist. J Pharmacol Exp Ther 262: 133-138, 1992.
5. 1 receptor blockade (Abstract). FASEB J 16: A502, 2002.
6. 1-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation. Am J Physiol Regul Integr Comp Physiol 281: R1844-R1853, 2001.
7. Chen Q H and Toney GM. Identification and characterization of two functionally distinct groups of spinal cord-projecting paraventricular nucleus neurons with sympathetic-related activity. Neuroscience 118: 797-807, 2003.
8. Chen QH and Toney GM. Sympathoexcitation by PVN injected bicuculline requires activation of excitatory amino acid receptors. Hypertension. In press.
9. Dampney RA, Fontes MA, Hirooka Y, Horiuchi J, Potts PD, and Tagawa T. Role of angiotensin II receptors in the regulation of vasomotor neurons in the ventrolateral medulla. Clin Exp Pharmacol Physiol 29: 467-472, 2002.
10. Decavel C and Van den Pol AN. GABA: a dominant neurotransmitter in the hypothalamus. J Comp Neurol 302: 1019-1037, 1990.
11. DiBona GF and Jones SY. Effect of dietary sodium intake on the responses to bicuculline in the paraventricular nucleus of rats. Hypertension 38: 192-197, 2001.
12. Eldefrawi AT and Eldefrawi ME. Receptors for gamma-aminobutyric acid and voltage-dependent chloride channels as targets for drugs and toxicants. FASEB J 1: 262-271, 1987.
13. Fenelon VS, Sieghart W, and Herbison AE. Cellular localization and differential distribution of GABAA receptor subunit proteins and messenger RNAs within hypothalamic magnocellular neurons. Neuroscience 64: 1129-1143, 1995.
14. Ferguson AV and Washburn DL. Angiotensin II: a peptidergic neurotransmitter in central autonomic pathways. Prog Neurobiol 54: 169-192, 1998.
15. Gao B, Fritschy JM, and Moore RY. GABA-A receptor sub-unit composition in the circadian timing system. Brain Res 700: 142-156, 1995.
16. Han SK, Chong W, Li LH, Lee IS, Murase K, and Ryu PD. Noradrenaline excites and inhibits GABAergic transmission in parvocellular neurons of rat hypothalamic paraventricular nucleus. J Neurophysiol 87: 2287-2296, 2002.
17. Haywood JR, Mifflin SW, Craig T, Calderon A, Hensler JG, and Hinojosa-Laborde C. γ-Aminobutyric acid (GABA)-A function and binding in the paraventricular nucleus of the hypothalamus in chronic renal-wrap hypertension. Hypertension 37: 614-618, 2001.
18. Herman JP, Eyigor O, Ziegler DR, and Jennes L. Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat. J Comp Neurol 422: 352-362, 2000.
19. Hermes ML, Ruijter JM, Klop A, Buijs RM, and Renaud LP. Vasopressin increases GABAergic inhibition of rat hypothalamic paraventricular nucleus neurons in vitro. J Neurophysiol 83: 705-711, 2000.
20. 1 receptors support blood pressure in hypertensive rats. Hypertension 40: 552-559, 2002.
21. Latchford KJ and Ferguson AV. Angiotensin II activates a nitric-oxide-driven inhibitory feedback in the rat paraventricular nucleus. J Neurophysiol 89: 1238-1244, 2003.
22. Li Z and Ferguson AV. Subfornical organ efferents to paraventricular nucleus utilize angiotensin as a neurotransmitter. Am J Physiol Regul Integr Comp Physiol 265: R302-R309, 1993.
23. Lind RW, Swanson LW, and Ganten D. Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study. Neuroendocrinology 40: 2-24, 1985.
24. Martin DS and Haywood JR. Hemodynamic responses to paraventricular nucleus disinhibition with bicuculline in conscious rats. Am J Physiol Heart Circ Physiol 265: H1727-H1733, 1993.
25. Martin DS and Haywood JR. Reduced GABA inhibition of sympathetic function in renal-wrapped hypertensive rats. Am J Physiol Regul Integr Comp Physiol 275: R1523-R1529, 1998.
26. McKinley M, Allen A, May C, McAllen R, Oldfield B, Sly D, and Mendelsohn F. Neural pathways from the lamina terminalis influencing cardiovascular and body fluid homeostasis. Clin Exp Pharmacol Physiol 28: 990-992, 2001.
27. Moga MM and Saper CB. Neuropeptide-immunoreactive neurons projecting to the paraventricular hypothalamic nucleus in the rat. J Comp Neurol 346: 137-150, 1994.
28. Pfister J, Felix D, and Imboden H. Immunohistochemical demonstration of angiotensin II receptors in rat brain by use of an anti-idiotypic antibody, Regul Pept 44: 109-117, 1993.
29. Rao ZR, Yamano M, Wanaka A, Tatehata T, Shiosaka S, and Tohyama M. Distribution of cholinergic neurons and fibers in the hypothalamus of the rat using choline acetyltransferase as a marker. Neuroscience 20: 923-934, 1987.
30. Rhaleb NE, Rouissi N, Nantel F, D'Orleans-Juste P, and Regoli D. DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17: 480-484, 1991.
31. Roland BL and Sawchenko PE. Local origins of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat. J Comp Neurol 332: 123-143, 1993.
32. Song K, Zhuo J, Allen AM, Paxinos G, and Mendelsohn FA. Angiotensin II receptor subtypes in rat brain and peripheral tissues. Cardiology 79, Suppl I: 45-54, 1991.
33. 1 receptors mediate excitatory inputs to rostral ventrolateral medulla pressor neurons from hypothalamus. Hypertension 34: 1301-1306, 1999.
34. Tsutsumi K and Saavedra JM. Quantitative autoradiography reveals different angiotensin II receptor subtypes in select rat brain nuclei. J Neurochem 56: 348-351, 1991.
35. Wei SG and Felder RB. Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity, Am J Physiol Heart Circ Physiol 282: H890-H895, 2002.
36. Zappia A, Hwang BH, and Wu JY. Increased density of glutamic acid decarboxylase-containing terminals in the medial preoptic nucleus and the area surrounding the paraventricular hypothalamic nucleus is associated with deoxycorticosterone acetate (DOCA)-salt hypertension. Anat Rec 227: 518-522, 1990.
37. Zaretskaia MV, Zaretsky DV, Shekhar A, and DiMicco JA. Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized rats. Brain Res 928: 113-125, 2002.
38. Zhang K, Li YF, and Patel KP. Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure. Am J Physiol Regul Integr Comp Physiol 282: R1006-R1015, 2002.
39. Zhang K and Patel KP. Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA. Am J Physiol Regul Integr Comp Physiol 275: R728-R734, 1998.
40. Zhang ZH, Francis J, Weiss RM, and Felder RB. The renin-angiotensin-aldosterone system excites hypothalamic paraventricular nucleus neurons in heart failure. Am J Physiol Heart Circ Physiol 283: H423-H433, 2002.