Role of hypoxemia in sleep apnea-induced sympathoexcitation

Journal of the Autonomic Nervous System

Volumn 56, Issue 3, 1996, Pages 184-190

  Smith, Michael L ^a,b   Niedermaier, Otfried N W ^a   Hardy, Seth M ^a   Decker, Michael J ^a   Strohl, Kingman P ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

Chemoreceptor; Microneurography; Obstructive sleep apnea; Sleep; Sympathetic nervous system

Indexed keywords

NITROGEN; OXYGEN;

ADULT; ARTICLE; CHEMORECEPTOR; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPOXEMIA; MALE; PRIORITY JOURNAL; SLEEP APNEA SYNDROME;

EID: 0030052594     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1838(95)00062-3     Document Type: Article

References (21)

1. Eckberg, D.L., Nerhed, C. and Wallin, B.G., Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man, J. Physiol., 365 (1985) 181-196.
2. Eyzaguirre, C. and Lewin, J., Chemoreceptor activity of the carotid body of the cat, J. Physiol., 159 (1961) 222-237.
3. Fitzgerald, R.S. and Dehghani, G.A., Neural responses of the cat carotid and aortic bodies to hypercapnia and hypoxia, J. Appl. Physiol., 52 (1982) 596-601.
4. Fukuda, Y., Sato, A., Suzuki, A. and Trzebski, A., Autonomic nerve and cardiovascular responses to changing blood oxygen and carbon dioxide levels in the rat, J. Auton. Nerv. Syst., 28 (1989) 61-74.
5. Gootman, P.M., Feldman, J.L. and Cohen, M.I., Pulmonary afferent influences on respiratory modulation of sympathetic discharge. In H.P. Koepchen, S.M. Hilton and A. Trzebski (Eds.) Central Interaction between respiratory and cardiovascular systems. Springer, Berlin, 1980, pp. 172-178.
6. Hedner, J., Ejnell, H., Sellgren, J., Hedner, T. and Wallin, G., Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension? J. Hypertens., 6 (1988) S529-S531 (Suppl. 4).
7. Hedner, J.A., Wilcox, I., Laks, L., Grunstein, R.R. and Sullivan, C.E., A specific and potent pressor effect of hypoxia in patients with sleep apnea, Am. Rev. Respir. Dis., 146 (1992) 1240-1245.
8. Hornyak, M., Cejnar, M., Elam, M., Matousek, M. and Wallin, B.G., Sympathetic muscle nerve activity during sleep in man, Brain, 114 (1991) 1281-1295.
9. Leuenberger, U., Gleeson, K., Wroblewski, K., Prophet, S., Zelis, R., Zwillich, C. and Sinoway, L., Norepinephrine clearance is increased during acute hypoxemia in humans, Am. J. Physiol., 261 (1991) H1659-H1664.
10. Matsumoto, S., Mokashi, A. and Lahiri, S., Cervical preganglionic sympathetic nerve activity and chemoreflexes in the cat, J. Appl. Physiol., 62 (1987) 1713-1720.
11. Morgan, B.J., Denahan, T. and Ebert, T.J., Neurocirculatory consequences of negative intrathoracic pressure vs. asphyxia during voluntary apnea, J. Appl. Physiol., 74 (1993) 2969-2975.
12. Rowell, L.B. and Seals, D.R., Sympathetic activity during graded central bypovolemia in hypoxemic humans, Am. J. Physiol. 259 (1990) H1197-H1206.
13. Smith, M.L., Carlson, M.D. and Thames, M.D., Naloxone does not prevent vasovagal syncope during simulated orthostasis in humans, J Auton. Nerv. Syst., 45 (1993) 1-9.
14. Smith, M.L., Decker, M.J. and Strohl, K.P., Peripheral and central chemoreflexes operate significantly below the threshold for activa tion in healthy humans, Physiologist. 35 (1992) 238.
15. Smith, M.L., Decker, M.J., Strohl, K.P. and Thames, M.D., Augmented peripheral chemoreflex gain in patients with obstructive sleep apnea syndrome (OSAS), Circulation. 86 (1992) 1-636
16. Smith, M.L., Ellenbogen, K.A., Eckberg, D.L. and Beightol, L.A., Human sympathetic neural responses to induced ventricular tachycardia, J. Am. Coll. Cardiol., 18 (1991) 1015-1024.
17. Somers, V.K., Dyken, M.E., Mark, A.L. and Abboud, F.M., Sympathetic-nerve activity during sleep in normal subjects, N. Engl. J. Med., 328 (1993) 303-307.
18. Somers, V.K., Mark, A.L. and Abboud, F.M., Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects, Hypertension. 11 (1988) 608-612.
19. Somers, V.K., Mark, A.L., Zavala, D.C. and Abboud, F.M., Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans, J. Appl. Physiol., 67 (1989) 2095-2100.
20. Somers, V.K., Mark, A.L., Zavala, D.C. and Abboud, F.M., Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans, J. Appl. Physiol., 67 (1989) 2101-2106.
21. Watanabe, T., Mano, T., Iwase, S., Sugiyama, Y., Okada, H., Takeuchi, S., Furui, H. and Kobayashi, F., Enhanced muscle sympathetic nerve activity during sleep apnea in the elderly, J. Auton. Nerv. Syst., 37 (1992) 223-227.