Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone

Hypertension

Volumn 46, Issue 2, 2005, Pages 341-348

  Gomes Da Silva, Ana Quênia ^a   Sousa Dos Santos, Robson Augusto ^a   Peliky Fontes, Marco Antônio ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Angiotensin; Angiotensin antagonist; Rats

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; A 779; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN[1-7]; CANDESARTAN; LOSARTAN; MUSCIMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTERIOR HYPOTHALAMUS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEART RATE; HYPERTENSION; MEAN ARTERIAL PRESSURE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; KIDNEY; MICROINJECTIONS; MUSCIMOL; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PEPTIDE FRAGMENTS; PYRIDINES; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; SYMPATHETIC NERVOUS SYSTEM;

EID: 23244452181     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000179216.04357.49     Document Type: Article

References (43)

1. Dampney RAL. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev. 1994;74:323-364.
2. Badoer E. Hypothalamic paraventricular nucleus and cardiovascular regulation. Clin Exp Pharmacol Physiol. 2001;28:95-99.
3. Martin DS, Haywood JR. Hemodynamic responses to paraventricular nucleus disinhibition with bicuculline in conscious rats. Am J Physiol. 1993;265:H1727-H1733.
4. Martin DS, Segura T, Haywood JK. Cardiovascular responses to bicuculline in the rat paraventricular nucleus. Hypertension. 1991;18:48-55.
5. Allen AM. Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone. Hypertension. 2002;39:275-280.
6. Veerasingham SJ, Raizada MK. Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br J Pharmacol. 2003;139:191-202.
7. Dampney RA, Fontes MA, Hirooka Y, Horiuchi J, Potts PD, Tagawa T. Role of angiotensin II receptors in the regulation of vasomotor neurons in the ventrolateral medulla. Clin Exp Pharmacol Physiol. 2002;29:467-472.
8. Santos RAS, Campagnole-Santos MJ, Andrade SP. Angiotensin-(1-7): an update. Regul Pept. 2000;91:45-62.
9. Santos RAS, Simões e Silva AC, Marie C, Silva DMR, Machado RP, Buhr I, Heringer-Walther S, Pinheiro SVB, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T. Angiotensin-(1-7) is an endogenous ligand for the G-protein-coupled receptor Mas. Proc Natl Acad Sci U S A. 2003;14:8258-8263.
10. Santos RAS, Campagnole-Santos MJ, Baracho NCV, Fontes MAP, Silva LCS, Neves LAA, Oliveira DR, Caligliorne SM, Rodrigues ARV, Gropen C Jr, Carvalho WS, Simões e Silva AC, Khosla MC. Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res Hull. 1994;35:293-298.
11. Averill DB, Diz DI. Angiotensin peptides and the baroreflex control of the sympathetic outflow: pathways and mechanisms of the medulla oblongata. Brain Res Bull. 1999;51:119-128.
12. Campagnole-Santos MJ, Dix DI, Santos RAS, Khosla MC, Brosnihan KB, Ferrario CM. Cardiovascular effects of angiotensin-(1-7) injected into the dorsal medulla of rats. Am J Physiol. 1989;257:H324-H329.
13. Barnes KL, Knowles WD, Ferrario CM. Angiotensin II and angiotensin-(1-7) excite neurons in the canine medulla in vitro. Brain Res Bull. 1990;24:275-280.
14. Silva LCS, Fontes MAP, Campagnole-Santos MJ, Khosla MC, Campos KR Jr, Guertzenstein PG, Santos RAS. Cardiovascular effects produced by microinjection of angiotcnsin-(1-7) on vasopressor and vasodepressor sites of the ventrolateral medulla. Brain Res. 1993;613:321-325.
15. Fontes MAP, Silva LCS, Campagnole-Santos MJ, Khosla MC, Guertzenstein PG, Santos RAS. Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors. Brain Res. 1994;665:175-180.
16. Fontes MAP, Baltatu O, Caligliorne SM, Ganten D, Bader M, Campagnole-Santos MJ, Santos RAS. Angiotensin peptides acting at the rostral ventrolateral medulla contribute to the hypertension of TGR(m-Rcn2)27 transgenic rat. Physiol Gen. 2000;2:137-142.
17. Ito S, Sved AF. Pharmacological profile of depressor response elicited by sarthran in rat ventrolateral medulla. Am J Physiol. 2000;279: H2961-H2966.
18. Felix D, Khosla MC, Barnes KL, Imboden H, Montani B, Ferrario CM. Neurophysiological responses to angiotensin-(1-7). Hypertension. 1991; 17:1111-1114.
19. Schiavone MT, Santos RAS, Brosnihan B, Khosla MC, Ferrario CM. Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide. Proc Natl Acad Sci U S A 1988;85:4095-4098.
20. Block CH, Santos RAS, Brosnihan KB, Ferrario CM. Immunocylochcmical localization of angiotensin-(1-7) in the rat forebrain. Peptides. 1989;9:1395-1401.
21. Krob HA, Visant SL, Ferrario CM, Friedman DP. Angiotensin-(1-7) immunoreactivity in the hypothalamus of the (mRen-2d)27 transgenic rat. Brain Res. 1998;798:36-45.
22. Chappell MC, Brosnihan KB, Diz DI, Ferrario CM. Identification of angiotensin-(1-7) in the rat brain. Evidence for differential processing of angiotensin peptides. J Biol Chem. 1989;264:16518-16523.
23. Ambuhl P, Felix D, Imboden H, Khosla MC, Ferrario CM. Effects of angiotensin analogues and angiotensin receptor antagonists on paraventricular neurons. Regul Pept. 1992;38:111-120.
24. Ambuhl P, Felix D, Khosla MC. [7-D-ALA]-Angiotensin-(1-7): selective antagonism of angiotensin-(1-7) in the rat paraventricular nucleus. Brain Res Bull. 1994;35:289-291.
25. Tagawa T, Horiuchi J, Potts PD, Dampney RAL. Sympathoinhibition after angiotensin receptor blockade in the rostral ventrolateral medulla is independent of glutamate and γ-aminobutyric acid receptors. J Anton Nerv Syst. 1999;77:21-30.
26. da Silva LG, de Menezes RC, dos Santos RA, Campagnole-Santos MJ, Fontes MA. Role of periaqueductul gray on the cardiovascular response evoked by disinhibition of the dorsomedial hypothalamus. Brain Res. 2003;984:206-214.
27. Paxinos G, Watson C. The Rat Brow in Stereotaxic Coordinates. New York. NY: Academic Press Inc. 1986.
28. Brown DA, Higgins AJ, March S, Smart TG. Actions of GABA on mammalian neurons, axons, and nerve terminals. In: DeFeudis FV, Mandel P. eds. Amino Acid Nenrotrunsniitters. New York. NY: Raven: 1981:321-326.
29. Chen QH, Toney GM. Responses to GABA-A receptor blockade in the hypothalamic PVN are attenuated by local AT1 receptor antagonism. Am J Physiol. 2003;285:R1231-R1239.
30. Chen QH, Toney GM. AT(1)-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation. Am J Physiol. 2001;281:R1844-R1853.
31. Zhu GQ, Gao L, Patel KP, Zucker IH, Wang W. Angiotensin 11 in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. J Appl Physiol. 2004;97:1746-1754.
32. Zhu GQ, Patel KP, Zucker I, Wang W. Microinjection of Ang II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats. Am J Physiol. 2002;282:H2039-H2045.
33. DiBona G. Neural control of the kidney: functionally specific renal sympathetic nerve fibers. Am J Physiol. 2000;279:R1517-R1524.
34. Hirooka Y, Potts PD, Dampney RAL. Role of angiotensin II receptor subtypes in mediating the sympathoexcitatory effects of exogenous and endogenous angiotensin peptides in the rostral ventrolateral medulla of the rabbit. Brain Res. 1997;772:107-114.
35. Ferrario CM, Chappel MC, Dean RH, Iyer SN. Novel angiotensin peptides regulate blood pressure, endothelial function, and natriuresis. J Am Soc Nephrol. 1998;9:1716-1722.
36. Heringer-Walther S, Batista EN, Walther T, Khosla MC, Santos RAS, Campagnole-Santos MJ. Baroreflex improvement in SHR after ACE inhibition involves angiotensin-(1-7). Hypertension. 2001;37:1309-1314.
37. Metzger R, Bader M, Ludwig T, Berberich C, Bunnemann B, Ganten D. Expression of the mouse and rat Mas proto-oncogene in the brain and peripheral tissues. FEBS Lett. 1995;357:27-32.
38. Welches WR, Santos RAS, Chappel MC, Brosnihan KB, Greene LJ, Ferrario CM. Evidence that prolyl endopeptidase participates in the processing of brain angiotensin. J Hypertens. 1991;9:631-638.
39. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, Oldfield BJ, Mendelsohn FAO, Chai SY. The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol. 2003;35:901-918.
40. Li DP, Chen SR, Pan HL. Angiotensin II stimulates projecting paraventricular neurons through presynaptic disinhibition. J Neurosci. 2003;23:5041-5049.
41. Gelhand CH, Zhu M, Lu D, Reagan LP, Fluharty SJ, Posner P, Raizada MK, Sumners C. Functional interactions between neuronal AT1 and AT2 receptors. Endocrinology. 1997;138:2195-2198.
42. Pinheiro SV, Simões e Silva AC, Sampaio WO, de Paula RD, Mendes EP, Bontempo ED, Pesquero JB, Walther T, Alenina N, Bader M, Bleich M, Santos RAS. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004;44:490-496.
43. Breitwieser GE. G-Protein-coupled receptor oligomerization: implications for G-protein activation and cell signaling. Circ Res. 2004;94:17-27.