SK-PC-B70M alleviates neurologic symptoms in G93A-SOD1 amyotrophic lateral sclerosis mice

Brain Research

Volumn 1368, Issue , 2011, Pages 299-307

  Seo, Ji Seon ^a   Baek, In Sun ^a   Leem, Yea Hyun ^a   Kim, Tae Kyung ^a   Cho, Yearin ^a   Lee, Soo Min ^b   Park, Yang Hae ^b   Han, Pyung Lim ^a  

^a Ewha Womans University   (South Korea)

^b SK Chemicals   (South Korea)

Author keywords

ALS; Antioxidant; Natural compound; Neuroprotection

Indexed keywords

4 HYDROXYNONENAL; CHOLINE ACETYLTRANSFERASE ANTIBODY; CRESYL VIOLET; DYE; ENZYME ANTIBODY; GLYCOSIDE; MALONALDEHYDE; OLEANOLIC ACID DERIVATIVE; SAPONIN DERIVATIVE; SK PC B70M; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; FEMALE; HISTOLOGY; LIPID PEROXIDATION; MALE; MORTALITY; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD VENTRAL HORN; SURVIVAL RATE; TRANSGENIC MOUSE;

ALDEHYDES; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTERIOR HORN CELLS; CELL SURVIVAL; CHOLINE O-ACETYLTRANSFERASE; DISEASE MODELS, ANIMAL; LIPID PEROXIDATION; MALONDIALDEHYDE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; SAPONINS; SPINAL CORD; SUPEROXIDE DISMUTASE;

MUS; MUS MUSCULUS; PULSATILLA KOREANA; RATTUS;

EID: 78651104123     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.10.048     Document Type: Article

References (43)

1. S.C. Barber, and P.J. Shaw Oxidative stress in ALS: key role in motor neuron injury and therapeutic target Free Radic. Biol. Med. 48 2010 629 641
2. G. Bensimon, L. Lacimbelz, and J.C. Delumeau A study of Riluzole in the treatment of advanced stage or elderly patients with amyptophoc lateral sclerosis J. Neuro. 249 2002 609 615
3. S. Boillee, K. Yamanaka, C.S. Lobsiger, N.G. Copeland, N.A. Jenkins, G. Kassiotis, G. Kollias, and D.W. Cleveland Onset and progression in inherited ALS determined by motor neurons and microglia Science 312 2006 1389 1392
4. S.E. Browne, L. Yang, J.P. DiMauro, S.W. Fuller, S.C. Licata, and M.F. Beal Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS Neurobiol. Dis. 22 2006 599 610
5. G.T. Carter, L.S. Krivickas, P. Weydt, M.D. Weiss, and R.G. Miller Drug therapy for amyotrophic lateral sclerosis: where are we now? Investig. Drugs J. 6 2003 147 153
6. I.H. Cho, J.Y. Im, D. Kim, K.S. Kim, J.K. Lee, and P.L. Han Protective effects of extracellular glutathione against Zn2 + -induced cell death in vitro and in vivo J. Neurosci. Res. 1 2003 736 743
7. D.W. Cleveland, and J.D. Rothstein From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS Nat. Rev. Neurosci. 2 2001 806 819
8. J.C. Corona, L.B. Tovar-y-Romo, and R. Tapia Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis Expert Opin. Ther. Targets 11 2007 1415 1428
9. K.J. De Vos, A.L. Chapman, M.E. Tennant, C. Manser, E.L. Tudor, K.F. Lau, J. Brownlees, S. Ackerley, P.J. Shaw, D.M. McLoughlin, C.E. Shaw, P.N. Leigh, C.C. Miller, and A.J. Grierson Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content Hum. Mol. Genet. 15 2007 2720 2728
10. L. Dupuis, A. Muller, V. Meininger, and J.P. Loeffler Molecular mechanisms of amyotrophic lateral sclerosis: recent contributions from studies in animal models Rev. Neurol (Paris). 160 2004 35 43
11. E. Esposito, M. Capasso, N. di Tomasso, C. Corona, F. Pellegrini, A. Uncini, P. Vitaglione, V. Fogliano, M. Piantelli, and S.L. Sensi Antioxidant strategies based on tomato-enriched food or pyruvate do not affect disease onset and survival in an animal model of amyotrophic lateral sclerosis Brain Res. 1168 2007 90 96
12. Ferraiuolo L., Heath P.R., Holden H., Kasher P., Kirby J., and Shaw P.J. Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS J. Neurosci. 27 2007 9201 9219
13. B. Frank, and S. Gupta A review of antioxidants and Alzheimer's disease Ann. Clin. Psychiatry 17 2005 269 286
14. M.E. Gurney, H. Pu, and A.Y. Chiu Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation Science 264 1994 1772 1775 (Pubitemid 24227760)
15. C.K. Han, W.R. Choi, and K.B. Oh Cognition-enhancing and neuroprotective effects of hederacolchiside-E from Pulsatilla koreana Planta Med. 73 2007 665 669
16. C.K. Han, Y.H. Park, D.Q. Jin, Y.K. Hwang, K.B. Oh, and J.S. Han SK-PC-B70M from Pulsatilla koreana improves scopolamine-induced impairments of memory consolidation and spatial working memory Brain Res. 1184 2007 254 259
17. J.Y. Im, D. Kim, S.G. Paik, and P.L. Han Cyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation Free Radic. Biol. Med. 41 2006 960 972
18. P. Kaufmann, J.L. Thompson, G. Levy, R. Buchsbaum, J. Shefner, L.S. Krivickas, J. Katz, Y. Rollins, R.J. Barohn, C.E. Jackson, E. Tiryaki, C. Lomen-Hoerth, C. Armon, R. Tandan, S.A. Rudnicki, K. Rezania, R. Sufit, A. Pestronk, S.P. Novella, T. Heiman-Patterson, E.J. Kasarskis, E.P. Pioro, J. Montes, R. Arbing, D. Vecchio, A. Barsdorf, H. Mitsumoto, and B. Levin Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III Ann. Neurol. 66 2009 235 244
19. H. Kim, H.Y. Kim, M.R. Choi, S. Hwang, K.H. Nam, H.C. Kim, J.S. Han, K.S. Kim, H.S. Yoon, and S.H. Kim Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice Neurosci. Lett. 468 2010 190 194
20. Y. Kosuge, K. Sekikawa-Nishida, H. Negi, K. Ishige, and Y. Ito Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice Neurosci. Lett. 24 2009 165 169
21. H. Kwiecinski, P. Janik, Z. Jamrozik, and A. Opuchlik The effect of selegiline and vitamin E in the treatment of ALS: an open randomized clinical trials Neurol. Neurochir. Pol. 35 Suppl 2001 101 106
22. L. Lacomblez, G. Bensimon, and P.N. Leigh Long-term safety of riluzole in amyotrophic lateral sclerosis: ALS Study Group I and II Amyotroph. Lateral Scler. Other Mot. Neuron Disord. 249 2002 23 29
23. B.H. LaMonte, K.E. Wallace, B.A. Holloway, S.S. Shelly, J. Ascaño, M. Tokito, T. Van Winkle, D.S. Howland, and E.L. Holzbaur Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration Neuron 30 2002 715 727
24. K.W. Lee, J.Y. Im, J.S. Song, S.H. Lee, H.J. Lee, H.Y. Ha, J.Y. Koh, B.J. Gwag, S.D. Yang, S.G. Paik, and P.L. Han Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein Neurobiol. Dis. 22 2006 10 24
25. K.W. Lee, J.B. Kim, J.S. Seo, T.K. Kim, J.Y. Im, I.S. Baek, K.S. Kim, J.K. Lee, and P.L. Han Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress J. Neurochem. 108 2009 165 175
26. E.G. McGeer, and P.L. McGeer Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis Biodrugs 19 2005 31 37
27. R.G. Miller, J.D. Mitchell, and M. Lyon Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) Amyotroph. Lateral Scler. Other Mot. Neuron Disord. 4 2003 191 206
28. H. Mitsumoto, D.A. Chad, and E.P. Pioro Amyotrophic lateral sclerosis 1998 Oxford Univ. press New York
29. J.A. Molina, F. de Bustos, and F.J. Jimenez-Jimenez Serum levels of coenzyme Q10 in patients with amyotrophic lateral sclerosis J. Neural Transm. 107 2000 1021 1026
30. D.W. Mulder Clinical limits of amyotrophic lateral sclerosis Adv. Neurol. 36 1982 15 22
31. M. Nagai, M. Aoki, I. Miyoshi, M. Kato, P. Pasinelli, N. Kasai, R.H. Brown Jr., and Y. Itoyama Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease J. Neurosci. 21 2001 9246 9254
32. P. Pasinelli, M.K. Houseweart, R.H. Brown Jr., and D.W. Cleveland Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis Proc. Natl Acad. Sci. USA 97 2000 13901 13906
33. E. Passage, J.C. Norreel, P. Noack-Fraissignes, V. Sanguedolce, J. Pizant, X. Thirion, A. Robaglia-Schlupp, J.F. Pellissier, and M. Fontés Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease Nat. Med. 10 2004 396 401
34. P. Piera, and H.B. Robert Molecular biology of amyotrophic lateral sclerosis: insights from genetics Nat. Neurosci. Rev. 7 2006 710 723
35. Radunović A., Delves H.T., Robberecht W., Tilkin P., Enayat Z.E., Shaw C.E., Stević Z., Apostolski S., Powell J.F., and Leigh P.N. Copper and Zinc levels in familial amyotrophic lateral sclerosis patients with Cu/Zn gene mutations Ann. Neurol. 42 1997 130 131
36. P.J. Shaw Molecular and cellular pathways of neurodegeneration in motor neurone disease J. Neurol. Neurosurg. Psychiatry 76 2005 1046 1057
37. P.J. Shaw, and P.G. Ince Glutamate, excitotoxicity and amyotrophic lateral sclerosis J. Neurol. 244 1997 3 14
38. J.S. Seo, E.Y. Jung, J.H. Kim, Y.S. Lyu, P.L. Han, and H.W. Kang A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease J. Ethnopharmacol. 130 2010 578 585
39. J.S. Seo, Y.H. Leem, K.W. Lee, S.W. Kim, J.K. Lee, and P.L. Han Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease J. Alzheimers Dis. 21 2010 263 276
40. J.S. Seo, T.K. Kim, Y.H. Leem, K.W. Lee, S.K. Park, I.S. Baek, S.K. Kim, G.J. Im, S.M. Lee, Y.H. Park, and P.L. Han SK-PC-B70M confers anti-oxidant activity and reduces Aβ levels in the brain of Tg2576 mice Brain Res. 1261 2009 100 108
41. M. Son, K. Puttaparthi, H. Kawamata, B. Rajendran, P.J. Boyer, G. Manfredi, and J.L. Elliott Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology Proc. Natl Acad. Sci. USA 104 2007 6072 6077
42. A. Vyth, J.G. Timmer, P.M. Bossuyt, E.S. Louwerse, and J.M. de Jong Survival in patients with amyotrophic lateral sclerosis, treated with an array of antioxidants J. Neurol. Sci. 139 suppl 1996 99 103
43. L.C. Wijesekera, and P.N. Leigh Amyotrophic lateral sclerosis Orphanet J. Rare Dis. 4 2009 32