Protective Effects of Extracellular Glutathione Against Zn 2+-Induced Cell Death In Vitro and In Vivo

Journal of Neuroscience Research

Volumn 74, Issue 5, 2003, Pages 736-743

  Cho Ik Hyun, I H ^a   Im, Joo Young ^a   Kim, Doyeun ^a   Kim, Kyoung Shim ^a   Lee, Ja Kyeong ^b   Han, Pyung Lim ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Inha University School of Medicine   (South Korea)

Author keywords

Astrocytes; Glutathione; Kainic acid; Neurons; Zn2+ toxicity

Indexed keywords

GLUTATHIONE; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN CELL; CELL CULTURE; CELL DEATH; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; GLIOSIS; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ASTROCYTES; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID AGONISTS; EXTRACELLULAR FLUID; GLUTATHIONE; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; KAINIC ACID; MICE; NEURONS; NEUROPROTECTIVE AGENTS; ZINC;

EID: 0345724974     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10794     Document Type: Article

References (43)

1. Andrews GK. 2001. Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals 14:223-237.
2. Burgalassi S, Chetoni P, Monti D, Saettone MF. 2001. Cytotoxicity of potential ocular permeation enhancers evaluated on rabbit and human corneal epithelial cell lines. Toxicol Lett 122:1-8.
3. Che Y, Yu Y-M, Han P-L, Lee J-K. 2001. Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure. Brain Res Mol Brain Res 94:157-165.
4. Chen CJ, Liao SL. 2003. Zinc toxicity on neonatal cortical neurons: involvement of glutathione chelation. J Neurochem 85:443-453.
5. Choi DW, Koh JY. 1998. Zinc and brai injury. Annu Rev Neurosci 21:347-375.
6. Choi DW, Maulucci-Gedde M, Kriegstein AR. 1987. Glutamate neurotoxicity in cortical cell culture. J Neurosci 7:357-368.
7. Conti F, DeBiasi S, Minelli A, Melone M. 1996. Expression of NR1 and NR2A/B subunits of the NMDA receptor in cortical astrocytes. Glia 17:254-258.
8. Cuajungco MP, Lees GJ. 1997. Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis 4:137-169.
9. Dineley KE, Scanlon JM, Kress GJ, Stout AK, Reynolds IJ. 2000. Astrocytes are more resistant than neurons to the cytotoxic effects of increased [Zn(2+)](i). Neurobiol Dis 7:310-320.
10. Dringen R. 2000. Metabolism and functions of glutathione in brain. Prog Neurobiol 618:181-189.
11. Dringen R, Gutterer JM, Hirrlinger J. 2000. Glutathione metabolism in brain; metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem 267:4912-4916.
12. Dugan LL, Bruno VM, Amagasu SM, Giffard RG. 1995. Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity. J Neurosci 15:4545-4555.
13. Fawcett JW, Asher RA. 1999. The glial scar and central nervous system repair. Brain Res Bull 49:377-391.
14. 2-induced neuronal oxidative stress. Mol Biol Rep 26:65-69.
15. Figueiredo-Pereira ME, Yakushin S, Cohen G. 1998. Disruption of the intracellular sulfhydryl homeostasis by cadmiun-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells. J Biol Chem 273:12703-12709.
16. Fitch MT, Doller C, Combs CK, Landreth GE, Silver J. 1999. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 19:8182-8198.
17. Franklin KB, Paxinos P. 1997. The mouse brain in stereotaxic coordinates. San Diego: Academic Press.
18. Frederickson CJ, Hernandez MD, Goik SA, Morton JD, McGinty JF. 1988. Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study. Brain Res 446:383-386.
19. Fuhr BJ, Rabenstein DL. 1973. Nuclear magnetic resonance studies of the solution chemistry of metal complexes. IX. The binding of cadmium, zinc, lead, and mercury by glutathione. J Am Chem Soc 95:6944-6950.
20. Grill E, Winnacker EL, Zenk MH. 1991. Phytochelatins. Methods Enzymol 205:333-341.
21. Hayashi Y, Isobe M, Mutoh N, Nakagawa CW, Kawabata M. 1991. Cadystins: small metal-binding peptides. Methods Enzymol 205:348-358.
22. Janssens N, Lesage AS. 2001. Glutamate receptor subunit expression in primary neuronal and secondary glial cultures. J Neurochem 77:1457-1474.
23. Kim D, Joe CO, Han P-L. 2003. Extracellular and intracellular glutathione protects astrocytes from Zn2+-induced cell death. Neuroreport 14:187-190.
24. Kim EY, Koh JY, Kim YH, Sohn S, Joe E, Gwag BJ. 1999a. Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures. Eur J Neurosci 11:327-334.
25. Kim YH, Kim EY, Gwag BJ, Sohn S, Koh JY. 1999b. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience 89:175-182.
26. Koh JY, Choi DW. 1987. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods 20:83-90.
27. Koh JY, Choi DW. 1994. Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors. Neuroscience 60:1049-1057.
28. Koh JY, Suh SW, Gwag BJ, He YY, Hsu CY, Choi DW. 1996. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272:1013-1016.
29. Liu D, Smith CL, Barone FC, Ellison JA, Lysko PG, Li K, Simpson IA. 1999. Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain. Brain Res Mol Brain Res 68:29-41.
30. Marotti T, Balog T, Munic V, Sobocanec S, Abramic M. 2000. The link between met-enkephalin-induced down-regulation of APN activity and the release of superoxide anion. Neuropeptides 34:121-128.
31. McNaught KS, Jenner P. 1999. Altered glial function causes neuronal death and increases neuronal susceptibility to 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced toxicity in astrocytic/ventral mesencephalic co-cultures. J Neurochem 73:2469-2476.
32. Noh KM, Kim YH, Koh JY. 1999. Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures. J Neurochem 72:1609-1616.
33. Noh KM, Koh JY. 2000. Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J Neurosci 20:RC111.
34. Piao CS, Che Y, Han P-L, Lee JK. 2002. Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemia. Brain Res Mol Brain Res 107:137-144.
35. Rizzardini M, Lupi M, Bernasconi S, Mangolini A, Cantoni L. 2003. Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid. J Neurol Sci 207:51-58.
36. Ryu R, Shin Y, Choi JW, Min W, Ryu H, Choi CR, Ko H. 2002. Depletion of intracellular glutathione mediates zinc-induced cell death in rat primary astrocytes. Exp Brain Res 143:257-263.
37. Sensi SL, Canzoniero LM, Yu SP, Ying HS, Koh JY, Kerchner GA, Choi DW. 1997. Measurement of intracellular free zinc in living cortical neurons: routes of entry. J Neurosci 17:9554-9564.
38. Sheline CT, Behrens MM, Choi DW. 2000. Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. J Neurosci 20:3139-3146.
39. Slivka A, Mytilineou C, Cohen G. 1987. Histochemical evaluation of glutathione in brain. Brain Res 409:275-284.
40. Son MH, Kang KW, Lee CH, Kim SG. 2001. Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase 1/2 (EKK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK). Complete inhibition of the potentiated toxicity by U0126 an EKK1/2 and p38 kinase inhibitor(1). Biochem Pharmacol 62:1379-1390.
41. Suh SW, Chen JW, Motamedi M, Bell B, Listiak K, Pons NF, Danscher G, Frederickson CJ. 2000. Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury. Brain Res 852:268-273.
42. Weiss JH, Sensi SL, Koh JY. 2000. Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci 21:395-401.
43. White AR, Cappai R. 2003. Neurotoxicity from glutathione depletion is dependent on extracellular trace copper. J Neurosci Res 71:889-897.