Thermogenesis challenges the adipostat hypothesis for body-weight control

Proceedings of the Nutrition Society

Volumn 68, Issue 4, 2009, Pages 401-407

  Cannon, Barbara ^a   Nedergaard, Jan ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Adipostat hypothesis; Brown adipose tissue; Thermogenesis; Uncouplers

Indexed keywords

UNCOUPLING PROTEIN 1;

BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONFERENCE PAPER; EXERCISE; FOOD INTAKE; HUMAN; HYPOTHESIS; NONHUMAN; OBESITY; THERMOGENESIS; WEIGHT CHANGE; WEIGHT CONTROL; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; CALORIC INTAKE; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

MUS;

ADIPOSE TISSUE, BROWN; ANIMALS; BODY WEIGHT; ENERGY INTAKE; HUMANS; MICE; OBESITY; THERMOGENESIS;

EID: 77949328118     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665109990255     Document Type: Conference Paper

References (30)

1. Kennedy GC (1953) The role of depot fat in the hypothalamic control of food intake in the rat. Proc Royal Soc Lond B Biol Sci 140, 578-592.
2. Dominguez SE, Menkel JL, Fairbrother A et al. (1993) The effect of 2,4-dinitrophenol on the metabolic rate of bobwhite quail. Toxicol Appl Pharmacol 123, 226-233.
3. Toyomizu M, Okamoto K, Tanaka M et al. (1992) Research note: effect of 2,4-dinitrophenol on growth and body composition of broilers. Poult Sci 71, 1096-1100.
4. Caldeira da Silva CC, Cerqueira FM, Barbosa LF et al. (2008) Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 7, 552-560.5. Cutting WC, Mehrtens HG & Tainter ML (1933) Actions and uses of dinitrophenol. Promising metabolic applications. J Am Med Assoc 101, 193.
5. Boveris A & Navarro A (2008) Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radic Biol Med 44, 224-229.
6. Golozoubova V, Gullberg H, Matthias A et al. (2004) Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all thyroid hormone receptors. Mol Endocrinol 18, 384-401.
7. Rippe C, Berger K, Boiers C et al. (2000) Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression. Am J Physiol Endocrinol Metab 279, E293-E300.
8. Nikonova L, Koza RA, Mendoza T et al. (2008) Mesodermspecific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J 22, 3925-3937.
9. Westerberg R, Månsson JE, Golozoubova V et al. (2006) ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. J Biol Chem 281, 4958-4968.
10. Lee S, Dobrzyn A, Dobrzyn P et al. (2004) Lack of stearoyl- CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J Lipid Res 45, 1674-1682.
11. Sampath H, Flowers MT, Liu X et al. (2009) Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high-fat diet-induced obesity. J Biol Chem 284, 19961-19973.
12. Erikson H, Krog J, Andersen KL et al. (1956) The critical temperature in naked man. Acta Physiol Scand 37, 35-39.
13. Nedergaard J, Golozoubova V, Matthias A et al. (2001) UCP1: the only protein able to mediate adaptive nonshivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta 1504, 82-106.
14. Golozoubova V, Hohtola E, Matthias A et al. (2001) Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J 15, 2048-2050.
15. Petrovic N, Shabalina IG, Timmons JA et al. (2008) Thermogenically competent non-adrenergic recruitment in brown predipocytes by a PPARg agonist. Am J Physiol Endocrinol Metab 295, E287-E296.
16. Sell H, Berger JP, Samson P et al. (2004) Peroxisome proliferator- activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice. Endocrinology 145, 3925-3934.
17. Trayhurn P, Thurlby PL & James W (1977) Thermogenic defect in pre-obese ob/ob mice. Nature 266, 60-62.
18. Himms-Hagen J (1979) Obesity may be due to a malfunctioning of brown fat. Can Med Assoc J 121, 1361-1364.
19. Rothwell NJ & Stock MJ (1979) A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35.
20. Enerbäck S, Jacobsson A, Simpson EM et al. (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94.
21. Liu X, Rossmeisl M, McClaine J et al. (2003) Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest 111, 399-407.
22. Feldmann HM, Golozoubova V, Cannon B et al. (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9, 203-209.
23. Nedergaard J, Bengtsson T & Cannon B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293, E444-E452.
24. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM et al. (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360, 1500-1508.
25. Virtanen KA, Lidell ME, Orava J et al. (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360, 1518-1525.
26. Saito M, Okamatsu-Ogura Y, Matsushita M et al. (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526-1531.
27. Zingaretti MC, Crosta F, Vitali A et al. (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J (Epublication ahead of print version; doi: 10.1096/fj.09-133546).
28. Esterbauer H, Oberkofler H, Liu Y et al. (1998) Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. J Lipid Res 39, 834-844.
29. Nagai N, Sakane N, Ueno LM et al. (2003) The - 3826 A!G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys. J Clin Endocrinol Metab 88, 5661-5667.
30. Sramkova D, Krejbichova S, Vcelak J et al. (2007) The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population. Exp Clin Endocrinol Diabetes 115, 303-307.