Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics

Molecular Pharmacology

Volumn 55, Issue 2, 1999, Pages 223-233

  Lytton, Simon D ^a   Helander, Anders ^b   Zhang Gouillon, Zhi Qi ^c   Stokkeland, Knut ^f   Bordone, Roberta ^d   Aricò, Sarino ^e   Albano, Emanuele ^d   French, Samuel W ^c   Ingelman Sundberg, Magnus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ST GÖRAN S HOSPITAL   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TURIN   (Italy)

^e MAURIZIANO HOSPITAL   (Italy)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CLOMETHIAZOLE; CYTOCHROME P450 INHIBITOR;

ADULT; AGED; ALCOHOLISM; ARTICLE; CHRONIC LIVER DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0032981322     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.2.223     Document Type: Article

References (45)

1. Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M and French SW (1996) Role of cytochrome P-4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 23:155-63.
2. Beaune P, Pessayre D, Dansette P, Mansuy D, Manns M (1994) Autoantibodies against cytochrome P-450: Role in human diseases. Adv Pharmacol 30:199-245.
3. Beaune PH, Lecoeur S, Bourdi M, Gauffre A, Belloc C, Dansette P and Mansuy D (1996) Anti-cytochrome P450 autoantibodies in drug-induced disease. Eur J Haematol Suppl 60:89-92.
4. Belloc C, Gauffre A, Andre C and Beaune PH (1997) Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis. Pharmacogenetics 7:181-186.
5. Bourdi M, Larrey D, Nataf J, Bernau J, Pessayre D, Iwasaki M, Guengerich FP and Beaune PH (1990) Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-4501A2. J Clin Invest 85:1967-1973.
6. Choudhuri K, Mieli-Vergani G and Vergani D (1997) Cytochrome P4502D6: understanding an autoantigen. Clin Exp Immunol 108:381-383.
7. Clot P, Albano E, Eliasson E, Tabone M, Aricò S, Israel Y, Moncada C and Ingelman- Sundberg M (1996) Cytochrome P4502E1 (CYP2E1) hydroxyethyl radical adducts as the major antigenic determinants for autoantibody formation among alcoholics. Gastroenterology 111:206-216.
8. Clot P, Bellomo G, Tabone M, Aricò S and Albano E (1995) Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis. Gastroenterology 108:201-207.
9. Dighiero G (1997) Natural autoantibodies, tolerance and autoimmunity. Ann NY Acad Sci 815:182-192.
10. Ekström G, von Bahr C and Ingelman Sundberg M (1989) Human liver microsomal ethanol-inducible cytochrome P450. Biochem Pharmacol 38:689-693.
11. Eliasson E and Kenna JG (1996) Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol Pharmacol 50:573-582.
12. George J and Shoenfeld Y (1996) Natural autoantibodies, in Autoantibodies (Peter JB and Shoenfeld Y eds) pp 534-539, Elsevier Science, New York.
13. Gillam EM, Guo Z and Guengerich FP (1994) Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties. Arch Biochem Biophys 312:59-66.
14. Greillier LFL and Dusheiko GM (1997) The role of hepatitis C virus in alcoholic liver disease. Alcohol Alcohol 32:103-111.
15. Guo Z, Gillam EM, Ohmori S, Tukey RH and Guengerich FP (1994) Expression of modified human cytochrome P450 1A1 in Escherichia coli: Effects of 5′ substitution, stabilization, purification, spectral characterization, and catalytic properties. Arch Biochem Biophys 312:436-446.
16. Halpert JR (1988) Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes. Arch Biochem Biophys 263:59-68.
17. Hasemann CA, Kurumbail RG, Boddupalli SS, Peterson JA and Deisenhofer AD (1995) Structure and function of cytochrome P450s: A comparative analysis of three crystal structures. Structure 2:41-62.
18. Hu Y, Mishin V, Johansson I, von Bahr C. Cross A, Ronis MJ, Badger TM and Ingelman-Sundberg M (1994) Clormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver. J Pharmacol Exp Ther 269:1286-1994.
19. Izumi N, Hasumura Y and Tacheuchi J (1983) Lymphocyte cytotoxicity for autologous human hepatocytes in alcoholic liver disease. Clin Exp Immunol 53:219-224.
20. Johansson I, Ekström G, Scholte D, Puzycki D, Jörnvall H and Ingelman-Sundberg M (1994) Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: Regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry 27:1925-1934.
21. Kostrubsky VE, Strom SC, Wood SG, Wrighton SA, Sinclair PR and Sinclair JF (1995) Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. Arch Biochem Biophys 322:516-520.
22. Kostrubsky VE, Szakacs JG, Jeffery EH, Wood SG, Bement WJ, Wrighton SA. Sinclair PR and Sinclair JF (1997) Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 143:315-323.
23. Krohn K, Uibo R, Aavik E, Peterson P and Savilahti K (1992) Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase. Lancet 339:770-773.
24. Laemmli UK (1970) Cleavage of structural properties during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
25. Lecoeur S, Andre C and Beaune Ph (1996) Tienilic acid-induced autoimmune hepatitis: Anti-liver and anti-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9. Mol Pharmacol 50: 326-333.
26. Leeder JS, Gaedigk A, Lu X and Cook VA (1996) Epitope mapping studies with human anti-cytochrome P450 3A antibodies. Mol Pharmacol 49:234-243.
27. Lingren S, Braun HB, Michel G, Nemeth A, Nilsson B, Thome-Kromer B and Eriksson S (1997) Absence of LKM-1 antibody reactivity in autoimmune and hepatitis C-related chronic liver disease in Sweden. Scand J Gastroenterol 32:175-178.
28. Loeper J, Descatoire V, Maurice M, Beaune P, Belghiti J, Houssin D, Bellet F, Feldmann G, Guengerich P and Pessayre D (1993) Cytochrome P450 in human hepatocyte plasma membrane: Recognition by several autoantibodies. Gastroenterology 104:203-216.
29. Loeper J, Descatoire V, Maurice M, Beaune P, Feldmann G, Larrey D and Pessayre D (1990) Presence of functional cytochrome P450 on isolated rat hepatocyte plasma membranes. Hepatology 11:850-858.
30. Louis CA, Wood SG, Kostrubsky V, Sinclair PR and Sinclair JF (1994) Synergic increases in rat hepatic cytochrome P450s by ethanol and isopentanol. J Pharmacol Exp Ther 269:838-845.
31. Manns MP, Griffin LC, Tan EM and Sullivan KF (1989) Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450dbl. J Clin Invest 83:1066-1072.
32. Paronetto F (1993) Immunologic reactions in alcoholic liver disease. Semin Liver Dis 13:183-195.
33. Riley RJ, Smith G, Wolf CR, Cook VA and Leeder JS (1993) Human anti-endoplasmic reticulum antibodies produced in aromatic anticonvulsant hypersensitivity reactions recognize rodent CYP3A proteins and a similarly regulated human P450 enzyme(s). Biochem Biophys Res Commun 191:32-40.
34. Robin MA, Le Roy M, Descatoire V and Pessayre D (1997) Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis. J Hepatol 26:23-30.
35. Robin M-A, Maratrat M, Le Roy M, Le Breton F-P, Bonierbale E, Dansette P, Ballet F, Mansuy D and Pessayre D (1996) Antigenic targets in tienilic acid hepatitis: Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. J Clin Invest 98:1471-1480
36. Ronis MJJ, Lindros KO and Ingelman-Sundberg M (1996) The cytochrome P4502E subfamily, in Cytochromes P450: Metabolic and Toxicological Aspects (C. Ioannides ed) pp 211-239, CRC Press Inc., Boca Raton.
37. Stibler H (1991) Carbohydrate-deficient transferrin in serum: A new marker of potentially harmful alcohol consumption reviewed. Clin Chem 37:2029-2037.
38. Strassburg CP and Manns MP (1995) Autoimmune hepatitis versus viral hepatitis C. Liver 15:225-232.
39. Takase S, Tsutsumi M, Kawahara H, Takada N and Takada A (1993) The alcohol-altered liver membrane antibody and hepatitis C virus infection in the progression of alcoholic liver disease. Hepatology 17:9-13.
40. Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC and Largman C (1985) Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5:224-232.
41. Tuma D and Klassen LW (1992) Immune response to acetaldehyde-protein adducts in alcoholic liver disease. Gastroenterology 103:1969-1973.
42. Uetrecht JP (1997) Current trends in drug-induced autoimmunity. Toxicology 119: 37-43.
43. Viitala K, Israel Y, Blake JE and Niemela O (1997) Serum IgA, IgG and IgM antibodies directed against acetaldehyde-derived epitopes: Relationship to liver disease severity and alcohol consumption. Hepatology 25:1418-1424.
44. Winqvist O, Gustafsson J, Rorsman F, Karlsson FA and Kämpe O (1993) Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease. J Clin Invest. 92:2377-2385.
45. Winqvist O, Karlsson FA and Kämpe O (1992) 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 339:1559-1562.