Computational methods for identifying a layered allosteric regulatory mechanism for ALS-causing mutations of Cu-Zn superoxide dismutase 1

Proteins: Structure, Function and Bioinformatics

Volumn 79, Issue 2, 2011, Pages 417-427

  Schuyler, Adam D ^a   Carlson, Heather A ^b   Feldman, Eva L ^c  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Amyotrophic lateral sclerosis (ALS); Correlated dynamics; Elastic network; Mutation ensemble; Network flow; Normal mode analysis (NMA)

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE;

ALLOSTERISM; AMYOTROPHIC LATERAL SCLEROSIS; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM;

ALLOSTERIC REGULATION; AMYOTROPHIC LATERAL SCLEROSIS; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, TERTIARY; SUPEROXIDE DISMUTASE;

EID: 78650771930     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22892     Document Type: Article

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