Aspartyl-(asparaginyl) β-hydroxylase, hypoxia-inducible factor-1α and Notch cross-talk in regulating neuronal motility

Oxidative Medicine and Cellular Longevity

Volumn 3, Issue 5, 2010, Pages 347-356

  Lawton, Margot ^a   Tong, Ming ^a,d   Gundogan, Fusun ^c,d   Wands, Jack R ^a,d   De La Monte, Suzanne M ^a,b,d  

^a Liver Research Center Brown University Medical School   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c WOMEN AND INFANTS HOSPITAL   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

Factor inhibiting HIF 1 ; Hydroxylation; Hypoxia inducible factor; Metastasis; Neuronal migration; Oxidative stress; Signal transduction

Indexed keywords

ASPARAGINYL; CELL MIGRATION; CELL MOTILITY; HYDROXYLASES; HYPOXIA INDUCIBLE FACTOR-1 ALPHA; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTORS; INSULIN-LIKE GROWTH FACTOR; METASTASIS; NEUROECTODERMAL TUMORS; NEURONAL CELL; NEURONAL MIGRATION; SHORT INTERFERING RNA; SIGNALING PATHWAYS; TRANSCRIPTION FACTOR EXPRESSION;

BACTERIOPHAGES; CROSSTALK; HYDROXYLATION; INSULIN; OXIDATIVE STRESS; PATHOLOGY; RNA; SIGNALING; TRANSCRIPTION FACTORS;

SIGNAL TRANSDUCTION;

ASPARTYL(ASPARAGINYL) BETA HYDROXYLASE; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; JAGGED1; NOTCH RECEPTOR; OXYGENASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROXYLATION; MOLECULAR INTERACTION; NERVE CELL; NEUROECTODERM TUMOR; OXIDATIVE STRESS; PROTEIN EXPRESSION;

CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; HYDROGEN PEROXIDE; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MIXED FUNCTION OXYGENASES; NEURONS; OXIDATIVE STRESS; RECEPTORS, NOTCH; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 78650722531     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.4161/oxim.3.5.13296     Document Type: Article

References (50)

1. Lavaissiere L.A., Nishiyama M, de la Monte S Stern AM, Wands JR, et al. Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma. J Clin Invest 1996; 98:1313-23.
2. Ince N, de la Monte SM, Wands JR. Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation. Cancer Res 2000; 60:1261-6.
3. Carter JJ, Tong M, Silbermann E, Lahousse SA, Ding FF, Longato L, et al. Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginylbeta- hydroxylase expression. Acta Neuropathol 2008; 116:303-15.
4. Lahousse SA, Carter JJ, Xu XJ, Wands JR, de la Monte SM. Differential growth factor regulation of aspartyl- (asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells. BMC Cell Biol 2006; 7:41.
5. de la Monte SM, Tamaki S, Cantarini MC, Ince N, Wiedmann M, Carter JJ, et al. Aspartyl-(asparaginyl)- beta-hydroxylase regulates hepatocellular carcinoma invasiveness. J Hepatol 2006; 44:971-83.
6. Monkovic DD, VanDusen WJ, Petroski CJ, Garsky VM, Sardana MK, Zavodszky P, et al. Invertebrate aspartyl/asparaginyl beta-hydroxylase: potential modification of endogenous epidermal growth factor-like modules. Biochem Biophys Res Commun 1992; 189:233-41.
7. Dinchuk JE, Henderson NL, Burn TC, Huber R, Ho SP, Link J, et al. Aspartyl beta-hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin. J Biol Chem 2000; 275:39543-54.
8. Dinchuk JE, Focht RJ, Kelley JA, Henderson NL, Zolotarjova NI, Wynn R, et al. Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J Biol Chem 2002; 277:12970-7.
9. Cotter D, Honavar M, Lovestone S, Raymond L, Kerwin R, Anderton B, et al. Disturbance of Notch-1 and Wnt signalling proteins in neuroglial balloon cells and abnormal large neurons in focal cortical dysplasia in human cortex. Acta Neuropathol (Berl) 1999; 98:465-72.
10. Christiansen JH, Coles EG, Wilkinson DG. Molecular control of neural crest formation, migration and differentiation. Curr Opin Cell Biol 2000; 12:719-24.
11. Cantarini MC, de la Monte SM, Pang M, Tong M, D'Errico A, Trevisani F, et al. Aspartyl-asparagyl beta hydroxylase overexpression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms. Hepatology 2006; 44:446-57.
12. Ryan HE, Lo J, Johnson RS. HIF-1alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998; 17:3005-15.
13. Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 2002; 8:62-7.
14. Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002; 16:1466-71.
15. Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002; 295:858-61.
16. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001; 292:464-8.
17. Sutter CH, Laughner E, Semenza GL. Hypoxiainducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 2000; 97:4748-53.
18. Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxiainducible factor 1alpha and insulin-like growth factor 2. Cancer Res 1999; 59:3915-8.
19. Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004; 5:343-54.
20. Zagzag D, Nomura M, Friedlander DR, Blanco CY, Gagner JP, Nomura N, et al. Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. J Cell Physiol 2003; 196:394-402.
21. Yang MH, Wu KJ. TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle 2008; 7:2090-6.
22. Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10:295-305.
23. Li W, Li Y, Guan S, Fan J, Cheng CF, Bright AM, et al. Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J 2007; 26:1221-33.
24. Pahlman S, Stockhausen MT, Fredlund E, Axelson H. Notch signaling in neuroblastoma. Semin Cancer Biol 2004; 14:365-73.
25. Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005; 9:617-28.
26. Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem 2007; 282:24027-38.
27. Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, et al. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci USA 2008; 105:3368-73.
28. De La Monte SM, Lahousse SA, Carter J, Wands JR. ATP luminescence-based motility-invasion assay. Biotechniques 2002; 33:98-100.
29. Treves S, Feriotto G, Moccagatta L, Gambari R, Zorzato F. Molecular cloning, expression, functional characterization, chromosomal localization and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane. J Biol Chem 2000; 275:39555-68.
30. Chen J, Imanaka N, Griffin JD. Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer 2010; 102:351-60.
31. Sahlgren C, Gustafsson MV, Jin S, Poellinger L, Lendahl U. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA 2008; 105:6392-7.
32. Sepe PS, Lahousse SA, Gemelli B, Chang H, Maeda T, Wands JR, et al. Role of the aspartyl-asparaginyl-betahydroxylase gene in neuroblastoma cell motility. Lab Invest 2002; 82:881-91.
33. Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, et al. Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential. Diabetes Metab Res Rev 2000; 16:434-41.
34. Yanagida T, Tsushima J, Kitamura Y, Yanagisawa D, Takata K, Shibaike T, et al. Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. Oxid Med Cell Longev 2009; 2:36-42.
35. Pristov JB, Spasojevic I, Mikovic Z, Mandic V, Cerovic N, Spasic M. Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide. Oxid Med Cell Longev 2009; 2:14-8.
36. de la Monte SM, Tong M, Carlson RI, Carter JJ, Longato L, Silbermann E, et al. Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. Alcohol 2009; 43:225-40.
37. Flugel D, Gorlach A, Michiels C, Kietzmann T. Glycogen synthase kinase 3 phosphorylates hypoxiainducible factor 1alpha and mediates its destabilization in a VHL-independent manner. Mol Cell Biol 2007; 27:3253-65.
38. Hooper C, Tavassoli M, Chapple JP, Uwanogho D, Goodyear R, Melino G, et al. TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones. J Neurochem 2006; 99:989-99.
39. Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003; 194:237-55.
40. Sivasankaran B, Degen M, Ghaffari A, Hegi ME, Hamou MF, Ionescu MC, et al. Tenascin-C is a novel RBPJkappa-induced target gene for Notch signaling in gliomas. Cancer Res 2009; 69:458-65.
41. Mikhailik A, Mazella J, Liang S, Tseng L. Notch liganddependent gene expression in human endometrial stromal cells. Biochem Biophys Res Commun 2009; 388:479-82.
42. Kopan R, Schroeter EH, Weintraub H, Nye JS. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 1996; 93:1683-8.
43. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998; 393:382-6.
44. The I, Murthy AE, Hannigan GE, Jacoby LB, Menon AG, Gusella JF, et al. Neurofibromatosis type 1 gene mutations in neuroblastoma. Nat Genet 1993; 3:62-6.
45. de la Monte SM, Ganju N, Wands JR. Microtiter immunocytochemical ELISA assay. Biotechniques 1999; 26:1073-6.
46. de la Monte SM, Neely TR, Cannon J, Wands JR. Oxidative stress and hypoxia-like injury cause Alzheimertype molecular abnormalities in central nervous system neurons. Cell Mol Life Sci 2000; 57:1471-81.
47. de la Monte SM, Ganju N, Feroz N, Luong T, Banerjee K, Cannon J, et al. Oxygen free radical injury is sufficient to cause some Alzheimer-type molecular abnormalities in human CNS neuronal cells. J Alzheimers Dis 2000; 2:261-81.
48. Gundogan F, Elwood G, Longato L, Tong M, Feijoo A, Carlson RI, et al. Impaired placentation in fetal alcohol syndrome. Placenta 2008; 29:148-57.
49. Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM. Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease. J Alzheimers Dis 2006; 9:13-33.
50. Cohen AC, Tong M, Wands JR, de la Monte SM. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcohol Clin Exp Res 2007; 31:1558-73.