Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-β-hydroxylase expression

Acta Neuropathologica

Volumn 116, Issue 3, 2008, Pages 303-315

  Carter, Jade J ^a   Tong, Ming ^a   Silbermann, Elizabeth ^a   Lahousse, Stephanie A ^a   Ding, Fei Fei ^a   Longato, Lisa ^a   Roper, Nitin ^a   Wands, Jack R ^a   de la Monte, Suzanne M ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Aspartyl (asparaginyl) hydroxylase; Caspase; Central nervous system; Fetal alcohol spectrum disorders; Glycogen synthase kinase 3 ; Insulin; Neuronal migration

Indexed keywords

ALCOHOL; ASPARTYLASPARAGINYL BETA HYDROXYLASE; CASPASE; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; OXYGENASE; SOMATOMEDIN C;

ARTICLE; CELL MIGRATION; CELL MOTILITY; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FETAL ALCOHOL SYNDROME; HUMAN; HUMAN CELL; NERVE CELL; NERVE CELL STIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ACTINS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL MOVEMENT; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHANOL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MIXED FUNCTION OXYGENASES; NEUROECTODERMAL TUMORS, PRIMITIVE; NEURONS; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 49049092565     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-008-0377-z     Document Type: Article

References (45)

1. Acquaah-Mensah GK, Kehrer JP, Leslie SW (2002) In utero ethanol suppresses cerebellar activator protein-1 and nuclear factor-kappa B transcriptional activation in a rat fetal alcohol syndrome model. J Pharmacol Exp Ther 301:277-283
2. Aronson M, Hagberg B, Gillberg C (1997) Attention deficits and autistic spectrum problems in children exposed to alcohol during gestation: A follow-up study. Dev Med Child Neurol 39:583-587
3. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (2002) Current protocols in molecular biology. Wiley, New York
4. Banerjee K, Mohr L, Wands JR, de la Monte SM (1998) Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells. Alcohol Clin Exp Res 22:2093-2101
5. Cantarini MC, de la Monte SM, Pang M, Tong M, D'Errico A, Trevisani F, Wands JR (2006) Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms. Hepatology 44:446-457
6. Carter EA, Wands JR (1988) Ethanol-induced inhibition of liver cell function: I. Effect of ethanol on hormone stimulated hepatocyte DNA synthesis and the role of ethanol metabolism. Alcohol Clin Exp Res 12:555-562
7. de la Monte SM, Chen GJ, Rivera E, Wands JR (2003) Neuronal thread protein regulation and interaction with microtubule-associated proteins in SH-Sy5y neuronal cells. Cell Mol Life Sci 60:2679-2691
8. de la Monte SM, Ganju N, Banerjee K, Brown NV, Luong T, Wands JR (2000) Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase. Alcohol Clin Exp Res 24:716-726
9. de la Monte SM, Ganju N, Wands JR (1999) Microtiter Immunocytochemical ELISA assay: A novel and highly sensitive method of quantifying immunoreactivity. Biotechniques 26:1073-1076
10. de la Monte SM, Lahousse SA, Carter J, Wands JR (2002) ATP luminescence-based motility-invasion assay. Biotechniques 33:98-100, 102, 104 passim
11. de la Monte SM, Neely TR, Cannon J, Wands JR (2001) Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons. Cell Mol Life Sci 58:1950-1960
12. de la Monte SM, Tamaki S, Cantarini MC, Ince N, Wiedmann M, Carter JJ, Lahousse SA, Califano S, Maeda T, Ueno T, D'Errico A, Trevisani F, Wands JR (2006) Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. J Hepatol 44:971-983
13. de la Monte SM, Wands JR (2001) Mitochondrial DNA damage and impaired mitochondrial function contribute to apoptosis of insulin-stimulated ethanol-exposed neuronal cells. Alcohol Clin Exp Res 25:898-906
14. de la Monte SM, Wands JR (2002) Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons. CMLS Cell Mol Life Sci 59:882-893
15. de la Monte SM, Xu XJ, Wands JR (2005) Ethanol inhibits insulin expression and actions in the developing brain. Cell Mol Life Sci 62:1131-1145
16. Dinchuk JE, Focht RJ, Kelley JA, Henderson NL, Zolotarjova NI, Wynn R, Neff NT, Link J, Huber RM, Burn TC, Rupar MJ, Cunningham MR, Selling BH, Ma J, Stern AA, Hollis GF, Stein RB, Friedman PA (2002) Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J Biol Chem 277:12970-12977
17. Goodlett CR, Horn KH, Zhou FC (2005) Alcohol teratogenesis: Mechanisms of damage and strategies for intervention. Exp Biol Med (Maywood) 230:394-406
18. Hausknecht KA, Acheson A, Farrar AM, Kieres AK, Shen RY, Richards JB, Sabol KE (2005) Prenatal alcohol exposure causes attention deficits in male rats. Behav Neurosci 119:302-310
19. Hu IC, Singh SP, Snyder AK (1995) Effects of ethanol on glucose transporter expression in cultured hippocampal neurons. Alcohol Clin Exp Res 19:1398-1402
20. Jia S, VanDusen WJ, Diehl RE, Kohl NE, Dixon RA, Elliston KO, Stern AM, Friedman PA (1992) cDNA cloning and expression of bovine aspartyl (asparaginyl) beta- hydroxylase. J Biol Chem 267:14322-14327
21. Karl PI, Fisher SE (1993) Ethanol alters hormone production in cultured human placental trophoblasts. Alcohol Clin Exp Res 17:816-821
22. Lahousse SA, Carter JJ, Xu XJ, Wands JR, de la Monte SM (2006) Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells. BMC Cell Biol 7:41
23. Lasky JL, Wu H (2005) Notch signaling, brain development, and human disease. Pediatr Res 57:104R-109R
24. Lavaissiere L, Jia S, Nishiyama M, de la Monte S, Stern AM, Wands JR, Friedman PA (1996) Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma. J Clin Invest 98:1313-1323
25. Li L, Mao J, Sun L, Liu W, Wu D (2002) Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 277:5977-5981
26. Li M, Linseman DA, Allen MP, Meintzer MK, Wang X, Laessig T, Wierman ME, Heidenreich KA (2001) Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J Neurosci 21:6544-6552
27. Liesi P (1997) Ethanol-exposed central neurons fail to migrate and undergo apoptosis. J Neurosci Res 48:439-448
28. Maier SE, West JR (2001) Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat. Alcohol 23:49-57
29. Minana R, Climent E, Barettino D, Segui JM, Renau-Piqueras J, Guerri C (2000) Alcohol exposure alters the expression pattern of neural cell adhesion molecules during brain development. J Neurochem 75:954-964
30. Ramachandran V, Perez A, Chen J, Senthil D, Schenker S, Henderson GI (2001) In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: A potential role for 4- hydroxynonenal. Alcohol Clin Exp Res 25:862-871
31. Riley EP, McGee CL (2005) Fetal alcohol spectrum disorders: An overview with emphasis on changes in brain and behavior. Exp Biol Med (Maywood) 230:357-365
32. Sepe PS, Lahousse SA, Gemelli B, Chang H, Maeda T, Wands JR, de la Monte SM (2002) Role of the aspartyl-asparaginyl-beta-hydroxylase gene in neuroblastoma cell motility. Lab Invest 82:881-891
33. Sheu JC, Hsu CP, Yang CC, Yang SD (1998) Acute inductive effects on oncogenic proline-directed protein kinase FA/GSK-3 alpha in NIH 3T3 cells by ethanol and cadmium. Proc Natl Sci Counc Repub China B 22:68-75
34. Singh SP, Gao Y, Kunapuli SP, Ravindra R (1999) Ethanol inhibits G-protein-mediated glucose uptake by C6 glioma cells. Neuroreport 10:595-599
35. Soscia SJ, Tong M, Xu XJ, Cohen AC, Chu J, Wands JR, de la Monte SM (2006) Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. Cell Mol Life Sci 63:2039-2056
36. Swanson DJ, King MA, Walker DW, Heaton MB (1995) Chronic prenatal ethanol exposure alters the normal ontogeny of choline acetyltransferase activity in the rat septohippocampal system. Alcohol Clin Exp Res 19:1252-1260
37. Tateno M, Ukai W, Ozawa H, Yamamoto M, Toki S, Ikeda H, Saito T (2004) Ethanol inhibition of neural stem cell differentiation is reduced by neurotrophic factors. Alcohol Clin Exp Res 28:134S-138S
38. The I, Murthy AE, Hannigan GE, Jacoby LB, Menon AG, Gusella JF, Bernards A (1993) Neurofibromatosis type 1 gene mutations in neuroblastoma. Nat Genet 3:2633-2642
39. van de Water B, Tijdens IB, Verbrugge A, Huigsloot M, Dihal AA, Stevens JL, Jaken S, Mulder GJ (2000) Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. J Biol Chem 275:25805-25813
40. Wang QP, VanDusen WJ, Petroski CJ, Garsky VM, Stern AM, Friedman PA (1991) Bovine liver aspartyl beta-hydroxylase. Purification and characterization. J Biol Chem 266:14004-14010
41. Xu J, Yeon JE, Chang H, Tison G, Chen GJ, Wands J, de la Monte S (2003) Ethanol impairs insulin-stimulated neuronal survival in the developing brain: Role of PTEN phosphatase. J Biol Chem 278:26929-26937
42. Yanni PA, Lindsley TA (2000) Ethanol inhibits development of dendrites and synapses in rat hippocampal pyramidal neuron cultures. Brain Res Dev Brain Res 120:233-243
43. Yoon K, Gaiano N (2005) Notch signaling in the mammalian central nervous system: Insights from mouse mutants. Nat Neurosci 8:709-715
44. Yuan H, Mao J, Li L, Wu D (1999) Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J Biol Chem 274:30419-30423
45. Zhang FX, Rubin R, Rooney TA (1998) Ethanol induces apoptosis in cerebellar granule neurons by inhibiting insulin-like growth factor 1 signaling. J Neurochem 71:196-204