Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis

Journal of Biological Chemistry

Volumn 279, Issue 10, 2004, Pages 8526-8529

  Hosfield, David J ^a   Zhang, Yanming ^a   Dougan, Douglas R ^a   Broun, Alexei ^a   Tari, Leslie W ^a   Swanson, Ronald V ^a   Finn, John ^b  

^a Takeda San Diego Inc   (United States)

^b Trilogy Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BONE; CATALYSIS; CONDENSATION; CONFORMATIONS; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYME INHIBITION; ENZYMES; NITROGEN; PHOSPHATES; TUMORS;

BONE RESORPTION; CARBOCATION;

BIOCHEMISTRY;

BISPHOSPHONIC ACID DERIVATIVE; ENZYME INHIBITOR; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; GERANYLTRANSFERASE; ISOPRENOID; NITROGEN ACID DERIVATIVE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME CONFORMATION; HYPERCALCEMIA; IONIZATION; LIGAND BINDING; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS; TARGET CELL;

ALKYL AND ARYL TRANSFERASES; DIPHOSPHONATES; ESCHERICHIA COLI; GERANYLTRANSTRANSFERASE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TERPENES;

EID: 1542275565     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300511200     Document Type: Article

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