Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein

Cancer Research

Volumn 61, Issue 9, 2001, Pages 3586-3590

  Chansky, H A ^a   Hu, M ^a   Hickstein, D D ^a   Yang, L ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; PROTEIN ERG; PROTEIN FLI1; PROTEIN TLS; RNA BINDING PROTEIN EWS; RNA POLYMERASE II; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CONTROLLED STUDY; EWING SARCOMA; LIPOSARCOMA; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RNA SPLICING; TRANSCRIPTION REGULATION;

3T3 CELLS; ADENOVIRUS E1A PROTEINS; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; COS CELLS; DNA-BINDING PROTEINS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; MICE; NFI TRANSCRIPTION FACTORS; ONCOGENE PROTEINS, FUSION; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEIN C-FLI-1; RIBONUCLEOPROTEINS; RNA POLYMERASE II; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEIN EWS; RNA-BINDING PROTEIN FUS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; Y-BOX-BINDING PROTEIN 1;

EID: 0035328667     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
2. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
3. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation
4. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing
5. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins
6. Gene regulation by Y-box proteins: Coupling control of transcription and translation
7. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
8. Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene
9. EWS-Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing
10. The transcriptional regulatory protein, YB-1, promotes single-stranded regions in the DRA promoter
11. The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS
12. Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development
13. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
14. Biology of EWS/FLI and related fusion genes in Ewing's sarcoma and primitive neuroectodermal tumor
15. Coupling RNA polymerase II transcription with pre-mRNA processing
16. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II
17. Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma
18. Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI- 1 fusion gene
19. Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity
20. Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines