Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A2 from Bothrops jararacussu

Toxicon

Volumn 57, Issue 1, 2011, Pages 100-108

  de Alvarenga, E S ^a   Silva, S A ^a   Barosa, Luiz Claudio Almeida ^a   Demuner, A J ^a   Parreira, A G ^d   Ribeiro, R I M A ^d   Marcussi, S ^e   Ferreira, J M S ^d   Resende, R R ^d   Granjeiro, P A ^d   Silva, J A ^d   Soares, A M ^b   Marangoni, S ^c   Da Silva, S L ^d  

^a FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO JOÃO DEL REI   (Brazil)

^e FEDERAL UNIVERSITY OF LAVRAS   (Brazil)

Author keywords

Bothrops jararacussu; Chemometrics; DFT; PLA2; Sesquiterpene lactone

Indexed keywords

COMPOUND LAC01; COMPOUND LAC02; COMPOUND LAC03; COMPOUND LAC04; COMPOUND LAC05; COMPOUND LAC06; COMPOUND LAC07; COMPOUND LAC08; PHOSPHOLIPASE A2; SESQUITERPENE LACTONE DERIVATIVE; SNAKE VENOM; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; ENZYME INHIBITION; ENZYME KINETICS; HYDROPHOBICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SNAKE; STRUCTURE ACTIVITY RELATION;

BOTHROPS JARARACUSSU;

EID: 78650678396     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.10.010     Document Type: Article

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