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Volumn 36, Issue 10, 2001, Pages 809-828

Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A2 inhibition: Syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines

(10) Binisti, Carine a Assogba, Léon a Touboul, Estéra a Mounier, Carine b Huet, Jack a Ombetta, Jean Edouard a Dong, Chang Zhi a Redeuilh, Catherine a Heymans, Françoise a Godfroid, Jean Jacques a

a Laboratoire de Pharmacochimie (France)

b INSTITUT PASTEUR (France)

Author keywords

Phospholipase A2 inhibitor; Piperazine; Structure activity relationships

Indexed keywords

1 (4 AMINOBENZENESULFONYL) 2 TRIDECYL 4 TRIPHENYLMETHYLPIPERAZINE; 1 (4 AMINOBENZENESULFONYL) 2 TRIDECYLPIPERAZINE; 1 (4 ETHYLCARBAMOYLBENZENESULFONYL) 2 TRIDECYLPIPERAZINE; 1 (4 METHOXYBENZENESULFONYL) 2 (8' TRIDECEN 1' YL)PIPERAZINE; 1 (4 N BENZOYLAMINOBENZENESULFONYL) 2 TRIDECYLPIPERAZINE; 1 (4 TOLYLSULFONYL) 2 OCTYL 4 METHYLPIPERAZINE; 1 (4 TOLYLSULFONYL) 3 TRIDECYLPIPERAZINE; 1 TRIPHENYLMETHYL 3 TRIDECYLPIPERAZINE; 1,4 DIBENZYL 2 HYDROXYMETHYLPIPERAZINE; 2 (8' TRIDECEN 1' YL)PYRAZINE; AMIDE; CARBON; PHOSPHOLIPASE A2; PIPERAZINE DERIVATIVE; SULFANILAMIDE; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CATTLE; CHEMICAL INTERACTION; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; LIPOPHILICITY; RABBIT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BLOOD PLATELETS; CALCIUM; CATALYTIC DOMAIN; CATTLE; CHELATING AGENTS; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; PANCREAS; PHOSPHOLIPASES A; PIPERAZINES; PLATELET ACTIVATING FACTOR; RABBITS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035492205 PISSN: 02235234 EISSN: None Source Type: Journal
DOI: 10.1016/S0223-5234(01)01274-0 Document Type: Article

Times cited : (21)

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