Ability of a synthetic coumestan to antagonize Bothrops snake venom activities

Toxicon

Volumn 55, Issue 2-3, 2010, Pages 488-496

  Melo, Paulo A ^a   Pinheiro, Diogo A ^a   Ricardo, Hilmar Dias ^a   Fernandes, Fabrício F A ^a   Tomaz, Marcelo A ^a   El Kik, Camila Z ^a   Strauch, Marcelo A ^a   da Fonseca, Tatiane F ^a   Sifuentes, Daniel N ^c   Calil Elias, Sabrina ^b   Buarque, Camilla D ^a   Brito, Flávia V ^a   Costa, Paulo R R ^a   Da Silva, Alcides J M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Administracao Farmaceutica   (Brazil)

^c UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Bothrops snake venoms; Myotoxicity and cardiotoxicity; Synthetic coumestans; Wedelolactone

Indexed keywords

8 METHOXY 3,9 DIHYDROXYCOUMESTAN DISODIUM; COUMESTROL DERIVATIVE; CREATINE KINASE; LQB 08; LQB 10; LQB 12; LQB 93; SNAKE VENOM; UNCLASSIFIED DRUG; WEDELOLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; ENZYME RELEASE; EXTENSOR DIGITORUM LONGUS MUSCLE; HEART PROTECTION; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; MALE; MOUSE; MUSCLE DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN BLEEDING; SNAKE;

ANIMALS; BOTHROPS; COUMARINS; COUMESTROL; CREATINE KINASE; CROTALID VENOMS; EDEMA; HEART; HEMORRHAGE; MICE; MUSCLE, SKELETAL; MYOCARDIUM; PEPTIDE HYDROLASES; PHOSPHOLIPASES; RATS;

BOTHROPS; BOTHROPS JARARACA; BOTHROPS JARARACUSSU; ECLIPTA PROSTRATA; RATTUS;

EID: 72749089141     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.09.021     Document Type: Article

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