Molecular modeling and inhibition of phospholipase A2 by polyhydroxy phenolic compounds

European Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2009, Pages 312-321

  da Silva, S L ^a   Calgarotto, A K ^b   Maso, V ^b   Damico, D C S ^b   Baldasso, P ^b   Veber, C L ^c   Villar, J A F P ^c   Oliveira, A R M ^c   Comar Jr , M ^a   Oliveira, K M T ^a   Marangoni, S ^b  

^a FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

DFT; Enzymatic kinetics; Molecular modeling; Phenolic compounds; PLA2

Indexed keywords

2,4,6 TRIHYDROXYACETOPHENONE; 2,6 DIHYDROXYACETOPHENONE; ACETOPHENONE DERIVATIVE; ALPHA TOCOPHEROL; ARISTOLOCHIC ACID; MEMBRANE PHOSPHOLIPID; PHENOL DERIVATIVE; PHLOROGLUCINOL; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; RESACETOPHENONE; RESORCINOL; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVITY; ENZYME INHIBITOR INTERACTION; FOOT EDEMA; FOOT PAD; INHIBITION KINETICS; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; QUANTUM CHEMISTRY;

ANIMALS; CROTALID VENOMS; DRUG DESIGN; EDEMA; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; PHENOLS; PHOSPHOLIPASES A2;

EID: 57949102171     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.043     Document Type: Article

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