Genistein stimulates duodenal HCO3- secretion through PI3K pathway in mice

European Journal of Pharmacology

Volumn 651, Issue 1-3, 2011, Pages 159-167

  Tuo, Biguang ^a   Wen, Guorong ^a   Song, Penghong ^b   Xu, Jingyu ^a   Liu, Xuemei ^a   Seidler, Ursula ^c   Dong, Hui ^a,d  

^a ZUNYI MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Bicarbonate secretion; CFTR; Duodenum; Genistein; Phosphatidylinositol 3 kinase

Indexed keywords

BICARBONATE; CALCIUM; CYCLIC AMP; CYCLIC GMP; ESTROGEN RECEPTOR; GENISTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL TISSUE; ARTICLE; BICARBONATE SECRETION; CONTROLLED STUDY; DUODENUM MUCOSA; DUODENUM SECRETION; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; BICARBONATES; CALCIUM; CYCLIC AMP; CYCLIC GMP; DUODENUM; ELECTRIC CONDUCTIVITY; ENZYME INHIBITORS; GENISTEIN; INTRACELLULAR SPACE; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION;

EID: 78650678165     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.070     Document Type: Article

References (49)

1. T. Akiyama, and H. Ogawara Use and specificity of genistein as an inhibitor of protein tyrosine kinases Methods Enzymol 201 1991 362 370
2. L. Al-Nakkash, S. Hu, M. Li, and T.C. Hwang A common mechanism for cystic fibrosis transmembrane conductance regulator protein activation by genistein and benzimidazolone analogs J. Pharmacol. Exp. Ther. 296 2000 464 472
3. L. Al-Nakkash, M.F. Springsteel, M.J. Kurth, and M.H. Nantz Activation of CFTR by UCCF-029 and genistein Bioorg. Med. Chem. Lett. 18 2008 3874 3877
4. C. Andersson, Z. Servetnyk, and G.M. Roomans Activation of CFTR by genistein in human airway epithelial cell lines Biochem. Biophys. Res. Commun. 308 2003 518 522
5. M. Atteritano, S. Mazzaferro, A. Frisina, M.L. Cannata, A. Bitto, R. D'Anna, F. Squadrito, I. Macri, N. Frisina, and M. Buemi Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopoenic postmenopausal women Osteoporos. Int. 20 2009 1947 1954
6. - secretion in mouse jejunum Am. J. Physiol. Cell Physiol. 287 2004 C1636 C1645
7. M.R. Banks, and M.J.G. Farthing Fluid and electrolyte transport in the small intestine Curr. Opin. Gastroenterol. 18 2002 176 181
8. S.J. Bhathena, and M.T. Velasquez Beneficial role of phytoestrogens in obesity and diabetes Am. J. Clin. Nutr. 76 2002 1191 1201
9. N.A. Bradbury Intracellular CFTR: localization and function Physiol. Rev. 79 1999 S175 S191
10. - secretion via phosphodiesterase modulation in the mouse jejunum Am. J. Physiol. Cell Physiol. 297 2009 C688 C698
11. C. Duffy, K. Perez, and A. Partridge Implications of phytoestrogen intake for breast cancer CA Cancer J. Clin. 57 2007 260 277
12. B.F. El-Rayes, S. Ali, I.F. Ali, P.A. Philip, J. Abbruzzese, and F.H. Sarkar Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kB Cancer Res. 66 2006 10553 10559
13. G. Flemström, and J.I. Isenberg Gastroduodenal mucosal alkaline secretion and mucosal production News Physiol. Sci. 16 2001 23 28
14. - channels via a tyrosine kinase and protein phosphatase-independent mechanism Am. J. Physiol. Cell Physiol. 273 1997 C747 C753
15. - secretion in the murine trachea and colon Am. J. Physiol. Cell Physiol. 279 2000 C383 C392
16. E. Grossini, C. Molinari, D.A.S.G. Mary, F. Uberti, P.P. Caimmi, N. Surico, and G. Vacca Intracoronary genistein acutely increases coronary blood flow in anesthetized pigs through β-adrenergic mediated nitric oxide release and estrogenic receptors Endocrinology 149 2008 2678 2687
17. W.B. Guggino, and B.A. Stanton New insights into cystic fibrosis: molecular switches that regulate CFTR Nature Rev. Mol. Cell. Biol. 7 2006 426 436
18. +-conductance in HEK-293 cells Cell. Physiol. Biochem. 13 2003 223 228
19. - secretion Am. J. Physiol. Gastrointest. Liver Physiol. 272 1997 G872 G878
20. D.S. Hutchinson, and T. Bengtsson alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway Endocrinology 146 2005 901 912
21. - channels by the tyrosine kinase inhibitor genistein Am. J. Physiol. Cell Physiol. 268 1995 C886 C893
22. J.I. Isenberg, J.A. Selling, D.L. Hogan, and M.A. Koss Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer N. Engl. J. Med. 316 1987 374 379
23. L. Jian Soy, isoflavones, and prostate cancer Mol. Nutr. Food Res. 53 2009 217 226
24. P.C. Konturek, S.J. Konturek, and E.G. Hahn Duodenal alkaline secretion: its mechanisms and role in mucosal protection against gastric acid Dig. Liver Dis. 36 2004 505 512
25. G.G.J.M. Kuiper, Lemme, n J.G., B. Carlsson, J.C. Corton, S.H. Safe, P.T. van der Saag, B. van der Burg, and I Gustafsson, J-A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β Endocrinology 139 1998 4252 4263
26. R.W. Lehrich, S.G. Aller, P. Webster, C.R. Marino, and J.N. Forrest Jr. Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, squalus acanthias: acute regulation of CFTR trafficking in an intact epithelium J. Clin. Invest. 101 1998 737 745
27. G.P.H. Leung, and P.Y.D. Wong Activation of cystic fibrosis transmembrane conductance regulator in rat epididymal epithelium by genistein Biol. Reprod. 62 2000 143 149
28. Y. Li, and F.H. Sarkar Inhibition of nuclear factor kB activation in PC3 cells by genistein is mediated via Akt signaling pathway Clin. Cancer Res. 8 2002 2369 2377
29. A. Lichtenstein Soy protein, isoflavones and cardiovascular disease risk J. Nutr. 128 1998 1589 1592
30. - cotransporter in renal epithelial A6 cells by flavonoids: genistein, daidzein, and apigenin Biochem. Biophys. Res. Commun. 254 1999 368 371
31. G. Powis, R. Bonjouklian, M.M. Berggren, A. Gallegos, R. Abraham, C. Ashendel, L. Zalkow, W.F. Matter, J. Dodge, and G. Grindey Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase Cancer Res. 54 1994 2419 2423
32. J.R. Riordan Assembly of functional CFTR chloride channels Annu. Rev. Physiol. 67 2005 701 718
33. 2-adrenergic receptors regulate cystic fibrosis transmembrane conductance regulator activity via a new pathway involving the mitogen-activated protein kinases extracellular signal-regulated kinases Mol. Pharmacol. 67 2005 648 654
34. G.M. Roomans Pharmacological treatment of the ion transport defect in cystic fibrosis Expert Opin. Investig. Drugs 10 2001 1 19
35. A. Schmidt, L.K. Hughes, Z. Cai, F. Mendes, H. Li, D.N. Sheppard, and M.D. Amaral Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator Br. J. Pharmacol. 153 2008 1311 1323
36. - secretion in T84 cell monolayers Am. J. Physiol. Gastrointest. Liver Physiol. 269 1995 G874 G882
37. - secretion J. Physiol. 505 1997 411 423
38. D.N. Sheppard, and M.J. Welsh Structure and function of the CFTR chloride channel Physiol. Rev. 79 1999 S23 S45
39. T. Simoncini, A. Hafezi-Moghadam, D.P. Brazil, K. Ley, W.W. Chin, and J.K. Liao Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase Nature 407 2000 538 541
40. T. Simoncini, E. Rabkin, and J.K. Liao Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells Arterioscler. Thromb. Vasc. Biol. 23 2003 198 203
41. A. Smith, C. Contreras, K.H. Ko, J. Chow, X. Dong, B. Tuo, H. Zhang, D. Chen, and H. Dong Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion Endocrinology 149 2008 4554 4566
42. T. Tamada, M. Nara, H. Kanatsuka, M. Nagaoka, R. Koshida, G. Tamura, and T. Hattori A potentiating effect of endogenous NO in the physiologic secretion from airway submucosal glands Am. J. Respir. Cell Mol. Biol. 37 2007 357 365
43. 4 receptors in mice Am. J. Physiol. Gastrointest. Liver Physiol. 286 2004 G444 G451
44. 2-mediated murine duodenal bicarbonate secretion Am. J. Physiol. Gastrointest. Liver Physiol. 293 2007 G279 G287
45. - conductance through the cystic fibrosis transmembrane conductance regulator anion channel by genistein and forskolin in murine duodenum Br. J. Pharmacol. 158 2009 1313 1321
46. B. Tuo, G. Wen, Y. Zhang, X. Liu, X. Wang, X. Liu, and H. Dong Involvement of phosphatidylinositol 3-Kinase in cAMP- and cGMP-induced duodenal epithelial CFTR activation in mice Am. J. Physiol. Gastrointest. Cell. Physiol. 293 2009 G279 G287
47. C.J. Vlahos, W.F. Matter, K.Y. Hui, and R.F. Brown A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4- one (LY294002) J. Biol. Chem. 269 1994 5241 5248
48. F. Weinreich, P.G. Wood, J.R. Riordan, and G. Nagel Direct action of genistein on CFTR Pflügers. Arch. 434 1997 484 491
49. X. Yang, S. Yang, C. McKimmey, B. Liu, S. Edgerton, W. Bales, L. Archer, and A.D. Thor Genistein induces enhanced growth promotion in ER positive/erbB-2 overexpressing breast cancers by ER-erbB-2 crosstalk and p27/kip1 downregulation Carcinogenesis 31 2010 695 702