메뉴 건너뛰기




Volumn 31, Issue 4, 2010, Pages 695-702

Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TAMOXIFEN; CDKN1B PROTEIN, HUMAN; ERBB2 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; SIGNAL PEPTIDE;

EID: 77249116901     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq007     Document Type: Article
Times cited : (33)

References (46)
  • 1
    • 0028216956 scopus 로고
    • Soy intake and cancer risk: a review of the in vitro and in vivo data
    • Messina, M.J. et al. (1994) Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer, 21, 113-131.
    • (1994) Nutr. Cancer , vol.21 , pp. 113-131
    • Messina, M.J.1
  • 2
    • 0034086069 scopus 로고    scopus 로고
    • Protection against breast cancer with genistein: a component of soy
    • discussion 1708S-1709S
    • Lamartiniere, C.A. (2000) Protection against breast cancer with genistein: a component of soy. Am. J. Clin. Nutr., 71, 1705S-1707S; discussion 1708S-1709S.
    • (2000) Am. J. Clin. Nutr. , vol.71
    • Lamartiniere, C.A.1
  • 3
    • 0036712514 scopus 로고    scopus 로고
    • Genistein action in the prepubertal mammary gland in a chemoprevention model
    • Cotroneo, M.S. et al. (2002) Genistein action in the prepubertal mammary gland in a chemoprevention model. Carcinogenesis, 23, 1467-1474.
    • (2002) Carcinogenesis , vol.23 , pp. 1467-1474
    • Cotroneo, M.S.1
  • 4
    • 0038520079 scopus 로고    scopus 로고
    • Hormonal and dietary modulation of mammary carcinogenesis in mouse mammary tumor virus-c-erbB-2 transgenic mice
    • Yang, X. et al. (2003) Hormonal and dietary modulation of mammary carcinogenesis in mouse mammary tumor virus-c-erbB-2 transgenic mice. Cancer Res., 63, 2425-2433.
    • (2003) Cancer Res. , vol.63 , pp. 2425-2433
    • Yang, X.1
  • 5
    • 0035394121 scopus 로고    scopus 로고
    • Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner
    • Allred, C.D. et al. (2001) Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res., 61, 5045-5050.
    • (2001) Cancer Res , vol.61 , pp. 5045-5050
    • Allred, C.D.1
  • 6
    • 0036569703 scopus 로고    scopus 로고
    • Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice
    • Ju, Y.H. et al. (2002) Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res., 62, 2474-2477.
    • (2002) Cancer Res , vol.62 , pp. 2474-2477
    • Ju, Y.H.1
  • 7
    • 13444252334 scopus 로고    scopus 로고
    • Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention
    • Liu, B. et al. (2005) Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res., 65, 879-886.
    • (2005) Cancer Res , vol.65 , pp. 879-886
    • Liu, B.1
  • 8
    • 0037423637 scopus 로고    scopus 로고
    • Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta
    • Margeat, E. et al. (2003) Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta. J. Mol. Biol., 326, 77-92.
    • (2003) J. Mol. Biol. , vol.326 , pp. 77-92
    • Margeat, E.1
  • 9
    • 0033036785 scopus 로고    scopus 로고
    • The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function
    • Miodini, P. et al. (1999) The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br. J. Cancer, 80, 1150-1155.
    • (1999) Br. J. Cancer , vol.80 , pp. 1150-1155
    • Miodini, P.1
  • 10
    • 0033587157 scopus 로고    scopus 로고
    • Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein
    • Li, Y. et al. (1999) Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene, 18, 3166-3172.
    • (1999) Oncogene , vol.18 , pp. 3166-3172
    • Li, Y.1
  • 11
    • 0023664272 scopus 로고
    • Genistein, a specific inhibitor of tyrosine-specific protein kinases
    • Akiyama, T. et al. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262, 5592-5595.
    • (1987) J. Biol. Chem. , vol.262 , pp. 5592-5595
    • Akiyama, T.1
  • 12
    • 0348230978 scopus 로고    scopus 로고
    • Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors
    • Lu, C. et al. (2003) Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors. J. Natl Cancer Inst., 95, 1825-1833.
    • (2003) J. Natl Cancer Inst. , vol.95 , pp. 1825-1833
    • Lu, C.1
  • 13
    • 0028944947 scopus 로고
    • Antioxidant and antipromotional effects of the soybean isoflavone genistein
    • Wei, H. et al. (1995) Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med., 208, 124-130.
    • (1995) Proc. Soc. Exp. Biol. Med. , vol.208 , pp. 124-130
    • Wei, H.1
  • 14
    • 0024431747 scopus 로고
    • Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II
    • Markovits, J. et al. (1989) Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res., 49, 5111-5117.
    • (1989) Cancer Res , vol.49 , pp. 5111-5117
    • Markovits, J.1
  • 15
    • 0032213459 scopus 로고    scopus 로고
    • Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells
    • Constantinou, A.I. et al. (1998) Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells. Eur. J. Cancer, 34, 1927-1934.
    • (1998) Eur. J. Cancer , vol.34 , pp. 1927-1934
    • Constantinou, A.I.1
  • 16
    • 0021132874 scopus 로고
    • Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer
    • Clark, G.M. et al. (1984) Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer. J. Clin. Oncol., 2, 1102-1109.
    • (1984) J. Clin. Oncol. , vol.2 , pp. 1102-1109
    • Clark, G.M.1
  • 17
    • 12144262323 scopus 로고    scopus 로고
    • The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer
    • McDonnell, D.P. (2005) The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer. Clin. Cancer Res., 11, 871s-877s.
    • (2005) Clin. Cancer Res. , vol.11
    • McDonnell, D.P.1
  • 18
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie, T. et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA, 98, 10869-10874.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1
  • 19
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie, T. et al. (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl Acad. Sci. USA, 100, 8418-8423.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8418-8423
    • Sorlie, T.1
  • 20
    • 0028670125 scopus 로고
    • The biology of erbB-2/neu/HER-2 and its role in cancer
    • Hynes, N.E. et al. (1994) The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim. Biophys. Acta, 1198, 165-184.
    • (1994) Biochim. Biophys. Acta , vol.1198 , pp. 165-184
    • Hynes, N.E.1
  • 21
    • 0026545620 scopus 로고
    • The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast
    • Liu, E. et al. (1992) The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast. Oncogene, 7, 1027-1032.
    • (1992) Oncogene , vol.7 , pp. 1027-1032
    • Liu, E.1
  • 22
    • 0034666345 scopus 로고    scopus 로고
    • Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer
    • Thor, A.D. et al. (2000) Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer. J. Clin. Oncol., 18, 3230-3239.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3230-3239
    • Thor, A.D.1
  • 23
    • 0027074588 scopus 로고
    • Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu
    • Benz, C.C. et al. (1993) Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu. Breast Cancer Res. Treat., 24, 85-95.
    • (1993) Breast Cancer Res. Treat. , vol.24 , pp. 85-95
    • Benz, C.C.1
  • 24
    • 0032864723 scopus 로고    scopus 로고
    • Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line
    • Alhasan, S.A. et al. (1999) Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line. Nutr. Cancer, 34, 12-19.
    • (1999) Nutr. Cancer , vol.34 , pp. 12-19
    • Alhasan, S.A.1
  • 25
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou, J. et al. (2004) Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl Cancer Inst., 96, 926-935.
    • (2004) J. Natl Cancer Inst. , vol.96 , pp. 926-935
    • Shou, J.1
  • 26
    • 17844398046 scopus 로고    scopus 로고
    • Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
    • Gutierrez, M.C. et al. (2005) Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J. Clin. Oncol., 23, 2469-2476.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2469-2476
    • Gutierrez, M.C.1
  • 27
    • 0030880014 scopus 로고    scopus 로고
    • Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells
    • Wang, C. et al. (1997) Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr. Cancer, 28, 236-247.
    • (1997) Nutr. Cancer , vol.28 , pp. 236-247
    • Wang, C.1
  • 28
    • 0033194698 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein
    • Li, Y. et al. (1999) Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein. Int. J. Oncol., 15, 525-533.
    • (1999) Int. J. Oncol. , vol.15 , pp. 525-533
    • Li, Y.1
  • 29
    • 0029830451 scopus 로고    scopus 로고
    • Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms
    • Yu, D. et al. (1996) Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms. Oncogene, 13, 1359-1365.
    • (1996) Oncogene , vol.13 , pp. 1359-1365
    • Yu, D.1
  • 30
    • 0035132464 scopus 로고    scopus 로고
    • Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin-and etoposide-induced apoptosis
    • Yang, X.H. et al. (2001) Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin-and etoposide-induced apoptosis. Cancer Res., 61, 348-354.
    • (2001) Cancer Res , vol.61 , pp. 348-354
    • Yang, X.H.1
  • 31
    • 34250869019 scopus 로고    scopus 로고
    • MDA-MB-435 cells are derived from M14 melanoma cells-a loss for breast cancer, but a boon for melanoma research
    • Rae, J.M. et al. (2007) MDA-MB-435 cells are derived from M14 melanoma cells-a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res. Treat., 104, 13-19.
    • (2007) Breast Cancer Res. Treat. , vol.104 , pp. 13-19
    • Rae, J.M.1
  • 32
    • 67650456890 scopus 로고    scopus 로고
    • MDA-MB-435 and M14 cell lines: identical but not M14 melanoma?
    • Chambers, A.F. (2009) MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? Cancer Res., 69, 5292-5293.
    • (2009) Cancer Res , vol.69 , pp. 5292-5293
    • Chambers, A.F.1
  • 33
    • 0026075305 scopus 로고
    • Use and specificity of genistein as inhibitor of protein-tyrosine kinases
    • Akiyama, T. et al. (1991) Use and specificity of genistein as inhibitor of protein-tyrosine kinases. Meth. Enzymol., 201, 362-370.
    • (1991) Meth. Enzymol. , vol.201 , pp. 362-370
    • Akiyama, T.1
  • 34
    • 0037151034 scopus 로고    scopus 로고
    • Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells A role for HER2 AND PKC-delta
    • Keshamouni, V.G. et al. (2002) Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta. J. Biol. Chem., 277, 22558-22565.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22558-22565
    • Keshamouni, V.G.1
  • 35
    • 8544284095 scopus 로고    scopus 로고
    • Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer
    • Surmacz, E. et al. (2004) Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer. J. Exp. Clin. Cancer Res., 23, 385-394.
    • (2004) J. Exp. Clin. Cancer Res. , vol.23 , pp. 385-394
    • Surmacz, E.1
  • 36
    • 0028886694 scopus 로고
    • Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
    • Kato, S. et al. (1995) Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science, 270, 1491-1494.
    • (1995) Science , vol.270 , pp. 1491-1494
    • Kato, S.1
  • 37
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    • Campbell, R.A. et al. (2001) Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J. Biol. Chem., 276, 9817-9824.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9817-9824
    • Campbell, R.A.1
  • 38
    • 28744431757 scopus 로고    scopus 로고
    • Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: implicated role of growth factor signaling and estrogen receptor coregulators
    • Schiff, R. et al. (2005) Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: implicated role of growth factor signaling and estrogen receptor coregulators. Cancer Chemother. Pharmacol., 56 (suppl. 1), 10-20.
    • (2005) Cancer Chemother. Pharmacol. , vol.56 , Issue.SUPPL. 1 , pp. 10-20
    • Schiff, R.1
  • 39
    • 0142244118 scopus 로고    scopus 로고
    • p27 as a target for cancer therapeutics
    • Blain, S.W. et al. (2003) p27 as a target for cancer therapeutics. Cancer Cell, 3, 111-115.
    • (2003) Cancer Cell , vol.3 , pp. 111-115
    • Blain, S.W.1
  • 40
    • 0036799377 scopus 로고    scopus 로고
    • PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
    • Shin, I. et al. (2002) PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat. Med., 8, 1145-1152.
    • (2002) Nat. Med. , vol.8 , pp. 1145-1152
    • Shin, I.1
  • 41
    • 18644370396 scopus 로고    scopus 로고
    • Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    • Viglietto, G. et al. (2002) Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat. Med., 8, 1136-1144.
    • (2002) Nat. Med. , vol.8 , pp. 1136-1144
    • Viglietto, G.1
  • 42
    • 0035419867 scopus 로고    scopus 로고
    • ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways
    • Lenferink, A.E. et al. (2001) ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res., 61, 6583-6591.
    • (2001) Cancer Res , vol.61 , pp. 6583-6591
    • Lenferink, A.E.1
  • 43
    • 0027194978 scopus 로고
    • Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation
    • Peterson, G. et al. (1993) Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate, 22, 335-345.
    • (1993) Prostate , vol.22 , pp. 335-345
    • Peterson, G.1
  • 44
    • 0035158466 scopus 로고    scopus 로고
    • Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice
    • Ju, Y.H. et al. (2001) Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J. Nutr., 131, 2957-2962.
    • (2001) J. Nutr. , vol.131 , pp. 2957-2962
    • Ju, Y.H.1
  • 45
    • 0035160104 scopus 로고    scopus 로고
    • Soy for breast cancer survivors: a critical review of the literature
    • Messina, M.J. et al. (2001) Soy for breast cancer survivors: a critical review of the literature. J. Nutr., 131, 3095S-3108S.
    • (2001) J. Nutr. , vol.131
    • Messina, M.J.1
  • 46
    • 33751289195 scopus 로고    scopus 로고
    • Effect of c-neu/ErbB2 expression levels on estrogen receptor alpha-dependent proliferation in mammary epithelial cells: implications for breast cancer biology
    • Shyamala, G. et al. (2006) Effect of c-neu/ErbB2 expression levels on estrogen receptor alpha-dependent proliferation in mammary epithelial cells: implications for breast cancer biology. Cancer Res., 66, 10391-10398.
    • (2006) Cancer Res , vol.66 , pp. 10391-10398
    • Shyamala, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.