Activation of CFTR by UCCF-029 and genistein

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 3874-3877

  Al Nakkash, Layla ^a   Springsteel, Mark F ^b   Kurth, Mark J ^c   Nantz, Michael H ^d  

^a MIDWESTERN UNIVERSITY   (United States)

^b Sierra College   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

CFTR; Genistein; Pharmacological activators; UCCF 029

Indexed keywords

ALPHA NAPHTHOFLAVONE; FORSKOLIN; GENISTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UC CF 029; 2 PYRIDIN 7,6 BENZOFLAVONE; 2-PYRIDIN-7,6-BENZOFLAVONE; ADENOSINE TRIPHOSPHATE; BENZOFLAVONE DERIVATIVE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; CHEMICAL MODEL; CHEMISTRY; CYSTIC FIBROSIS; DOSE RESPONSE; DRUG DESIGN; GENETIC TRANSFECTION; HYDROLYSIS; METABOLISM; MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOFLAVONES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FORSKOLIN; GENISTEIN; HYDROLYSIS; MICE; MODELS, CHEMICAL; NIH 3T3 CELLS; PROTEIN KINASE INHIBITORS; TRANSFECTION;

EID: 47149096521     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.051     Document Type: Article

References (19)

1. Riordan J.R., Rommens J.M., Kerem B.-S., Alon N., Rozmahel R., Grzelczak Z., Zielenski J., Lok S., Plavsik N., Chou J.-L., Drumm M.L., Iannuzzi M.C., Collins F.S., and Tsui L.-C. Science 245 (1989) 1066
2. Welsh M.J., and Smith A.E. Cell 73 (1993) 1251
3. Dalemans W., Barbury P., Champigny G., Jallat S., Dott K., Dreyer D., Crystal R.G., Pavirani A., Lecocq J.P., and Lazdunski M. Nature 354 (1991) 503
4. Haws C.M., Nepomuceno I.B., Krouse M.E., Wakelee H., Law T., Xia Y., Nguyen H., and Wine J.J. Am. J. Physiol. 270 (1996) C1544
5. Al-Nakkash L., and Hwang T.-C. Pflugers Arch. 437 (1999) 553
6. Al-Nakkash L., Shenghui H., Li M., and Hwang T.-C. J. Pharmacol. Exp. Ther. 296 (2001) 464
7. Berger A.L., Randak C.O., Ostedgaard L.S., Karp P.H., Vermeer D.W., and Welsh M.J. J. Biol. Chem. 280 (2005) 5221
8. Noel S., Faveau C., Norez C., Rogier C., Mettey Y., and Becq F. J. Pharmacol. Exp. Ther. 319 (2006) 349
9. Suen Y.F., Robins L., Yang B., Verkman A.S., Nantz M.H., and Kurth M. Bioorg. Med. Chem. Lett. 16 (2006) 537
10. Yoo C.L., Yu G.J., Yang B., Robins L., Verkman A.S., and Kurth M. Bioorg. Med. Chem. Lett. 18 (2008) 2610
11. Galietta L.J.V., Springsteel M.F., Eda M., Niedzinski E.J., By K., Haddadin M.J., Kurth M.J., Nantz M.H., and Verkman A.S. J. Biol. Chem. 276 (2001) 19723
12. Caci E., Folli C., Zegarra-Moran O., Ma T., Springsteel M.F., Sammelson R.E., Nantz M.H., Kurth M.J., Verkman A.S., and Galietta L.J.V. Am. J. Physiol. 285 (2003) L180
13. He Z., Raman S., Guo Y., and Reenstra W.W. Am. J. Physiol. 275 (1998) C958
14. Illek B., Fischer H., and Machen T.E. Am. J. Physiol. 270 (1996) C265
15. Hwang T.-C., Wang F., Yang I.C.-H., and Reenstra W.W. Am. J. Physiol. 273 (1997) C988
16. Zeltwanger S., Wang F., Wang G.-T., Gillis K., and Hwang T.-C. J. Gen. Physiol. 113 (1999) 541
17. Becq F., Mettey Y., Gray M.A., Galietta L.J.V., Dormer R.L., Merten M., Metaye T., Chappe V., Marvingt-Mounir C., Zegarra-Moran O., Tarran R., Bulteau L., Derand R., Kammouni W., Figarella C., Verrier B., Gola M., and Vierfond J.-M. J. Biol. Chem. 274 (1999) 27415
18. Illek B., Fischer H., Santos G.F., Widdicombe J.H., Machen T.E., and Reenstra W.W. Am. J. Physiol. 268 (1995) C886
19. Gunderson K.L., and Kopito R.R. Cell 82 (1995) 231