CFTR mediates cAMP- and Ca2+-activated duodenal epithelial HCO3/- secretion

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 4 35-4, 1997, Pages

  Hogan, Daniel L ^a,b,c   Crombie, Diane L ^a   Isenberg, Jon I ^b   Svendsen, Per ^a   Schaffalitzky De Muckadell, Ove B ^a   Ainsworth, Mark A ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UCSD MEDICAL CENTER   (United States)

Author keywords

acid base transport; bicarbonate; conductance; cystic fibrosis transmembrane conductance regulator; murine

Indexed keywords

BICARBONATE; CALCIUM ION; CARBACHOL; CYCLIC AMP; FORSKOLIN; SODIUM CHLORIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ACID BASE BALANCE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DUODENUM MUCOSA; DUODENUM SECRETION; FEMALE; GENOTYPE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030977383     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.4.g872     Document Type: Article

References (41)

1. Anderson, M. P., D. P. Rich, R. J. Gregory, A. E. Smith, and M. J. Welsh. Generation of cAMP-activated chloride currents by expression of CFTR. Science 251: 679-682, 1991.
2. Anderson, M. P., D. N. Sheppard, H. A. Berger, and M. J. Welsh. Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L1-L4, 1992.
3. Anderson, M. P., and M. J. Welsh. Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia. Proc. Natl. Acad. Sci. USA 88: 6003-6007, 1991.
4. - exchange and anion conductance in rat duodenal apical membrane vesicles. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20): G661-G667, 1989.
5. - conductance sensitive to external pH in the apical membrane of rat duodenal enterocytes. J. Physiol. (Lond.) 456: 519-528, 1992.
6. Clarke, L. L., B. R. Grubb, S. E. Gabriel, O. Smithies, B. H. Koller, and R. C. Boucher. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science 257: 1125-1128, 1992.
7. Clarke, L. L., B. R. Grubb, J. R. Yankaskas, C. U. Cotton, A. McKenzie, and R. C. Boucher. Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proc. Natl. Acad. Sci. USA 91: 479-483, 1994.
8. + absorption in a cystic fibrosis model. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G259-G267, 1996.
9. Cohn, J. A. Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells. Gastroenterology 105: 1857-1864, 1993.
10. Cuthbert, A. W., L. J. MacVinish, M. E. Hickman, R. Ratcliff, and W. H. Colledge. Ion-transporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis. Pflügers Arch. 428: 508-515, 1994.
11. - exchange in rat duodenal brush border membrane vesicles by cAMP. Pflugers Arch. 414: 701-705, 1989.
12. Fitz, J. G. Regulation of membrane chloride channels in rat bile ductular epithelial cells. J. Clin. Invest. 91: 319-328, 1993.
13. Flemstrom, G. Gastric and duodenal mucosal bicarbonate secretion. In: Physiology of the Gastrointestinal Tract (2nd ed.), edited by L. R. Johnson, J. Christensen, M. J. Jackson, E. D. Jacobson, and J. H. Walsh. New York: Raven, 1987, p. 1011-1030.
14. - transport: characteristics and proposed role in acidity regulation and mucosal protection. Am. J. Physiol. 242 (Gastrointest. Liver Physiol. 5): G183-G193, 1982.
15. - transport in vitro: effects of hormones and local transmitters. Am. J. Physiol. 242 (Gastrointest. Liver Physiol. 5): G100-G110, 1982.
16. - transport by duodenal epithelia. In: Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, edited by A. Allen, G. Flemstrom, A. Garner, W. Silen, and L. A. Turnberg. New York: Raven, 1984, p. 153-158.
17. Gray, M. A., A. Harris, L. Coleman, J. R. Greenwell, and B. E. Argent. Two types of chloride channels on duct cells cultured from human fetal pancreas. Am. J. Physiol. 257 (Cell Physiol. 26): C240-C251, 1989.
18. Grubb, B. R. Ion transport across the jejunum in normal and cystic fibrosis mice. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G505-G513, 1995.
19. - transport by luminal acid in the frog in vitro. Am. J. Physiol. 246 (Gastrointest. Liver Physiol. 9): G235-G242, 1984.
20. Hogan, D. L., and J. I. Isenberg. Gastroduodenal bicarbonate production. Adv. Intern. Med. 33: 385-408, 1988.
21. Hogan, D. L., B. Yao, J. H. Steinbach, and J. I. Isenberg. The enteric nervous system modulates mammalian duodenal mucosal bicarbonate secretion. Gastroenterology 105: 410-417, 1993.
22. Marino, C. R., L. M. Matovcik, F. S. Gorelick, and J. A. Cohn. Localization of the cystic fibrosis transmembrane conductance regulator in the pancreas. J. Clin. Invest. 88: 712-716, 1991.
23. Poulsen, J. H., H. Fischer, B. Illek, and T. E. Machen. Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc. Natl. Acad. Sci. USA 91: 5340-5344, 1994.
24. Quinton, P. M. Cystic fibrosis: a disease in electrolyte transport. FASEB J. 4: 2709-2717, 1990.
25. Ratcliff, R., M. J. Evans, A. W. Cuthbert, J. L. MacVinish, D. Foster, J. R. Anderson, and W. H. Colledge. Production of a severe cystic fibrosis mutation in mice by gene targeting. Nat. Genet. 4: 35-41, 1993.
26. Riordan, J. R. Identification of the cystic fibrosis gene: cloning and characterization of complimentary DNA. Science 245: 1066-1073, 1989.
27. Rommens, J. M. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245: 1059-1065, 1989.
28. Simson, J. N. L., A. Merhav, and W. Silen. Alkaline secretion by amphibian duodenum. I. General characteristics. Am. J. Physiol. 240 (Gastrointest. Liver Physiol. 3): G401-G408, 1981.
29. - fluxes. Am. J. Physiol. 240 (Gastrointest. Liver Physiol. 3): G472-G479, 1981.
30. Simson, J. N. L., A. Merhav, and W. Silen. Alkaline secretion by amphibian duodenum. III. Effect of DBcAMP, theophylline, and prostaglandins. Am. J. Physiol. 241 (Gastrointest. Liver Physiol. 4): G528-G536, 1981.
31. Smith, S. N., D. M. Steel, P. G. Middleton, F. M. Munkonge, D. M. Geddes, N. J. Caplen, D. J. Porteous, J. R. Dorin, and E. W. F. W. Alton. Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans. Am. J. Physiol. 268 (Cell Physiol. 37): C297-C307, 1995.
32. Snouwaert, J. N., K. K. Brigman, A. M. Latour, N. N. Malouf, R. C. Boucher, O. Smithies, and B. H. Holler. An animal model for cystic fibrosis made by gene targeting. Science 257: 1083-1088, 1992.
33. Strong, T. V., K. Boehm, and F. S. Collins. Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization. J. Clin. Invest. 93: 347-354, 1994.
34. - channel in CHO cells stably expressing the cystic fibrosis gene. Nature 352: 628-631, 1991.
35. Tabcharani, J. A., T. J. Jensen, J. R. Riordan, and J. W. Hanrahan. Bicarbonate permeability of the outwardly rectifying anion channel. J. Membr. Biol. 12: 109-122, 1989.
36. Trezise, A. E. O., and M. Buchwald. In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator. Nature 353: 434-437, 1991.
37. Welsh, M. J. Abnormal regulation of ion channels in cystic fibrosis epithelia. FASEB J. 4: 2718-2725, 1990.
38. 2, and cyclic adenosine monophosphate. Gastroenterology 104: 732-740, 1993.
39. Yao, B. G., D. L. Hogan, M. A. Ainsworth, and J. I. Isenberg. Importance of acid/base transporters in bicarbonate secretion by rabbit proximal duodenum (Abstract). Gastroenterology 106: A214, 1994.
40. Yao, B. G., D. L. Hogan, M. A. Koss, and J. I. Isenberg. Inhibition of anion channels abolishes duodenal mucosal bicarbonate secretion (Abstract). Gastroenterology 104: A292, 1993.
41. + exchanger gene family: structure and function studies. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G1-G11, 1995.