Differential activation of the HCO 3 - conductance through the cystic fibrosis transmembrane conductance regulator anion channel by genistein and forskolin in murine duodenum

British Journal of Pharmacology

Volumn 158, Issue 5, 2009, Pages 1313-1321

  Tuo, Biguang ^a   Wen, Guorong ^a   Seidler, Ursula ^b  

^a ZUNYI MEDICAL UNIVERSITY   (China)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Bicarbonate secretion; CFTR; Duodenum

Indexed keywords

ADENYLATE CYCLASE; ANION CHANNEL; BICARBONATE; CHLORIDE ION; FORSKOLIN; GENISTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG TRANSPORT; DUODENUM MUCOSA; IN VITRO STUDY; MEMBRANE CONDUCTANCE; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; SHORT CIRCUIT CURRENT;

ANIMALS; ANIONS; BICARBONATES; CHLORIDES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DUODENUM; FORSKOLIN; GENISTEIN; INTESTINAL MUCOSA; ION TRANSPORT; MICE; MICE, KNOCKOUT; MUTATION;

EID: 70849135988     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00398.x     Document Type: Article

References (37)

1. Al-Nakkash L, Hu S, Li M, Hwang TC (2001). A common mechanism for cystic fibrosis transmembrane conductance regulator protein activation by genistein and benzimidazole analogs. J Pharmacol Exp Ther 296: 464-472. (Pubitemid 32112474)
2. Andersson C, Servetnyk Z, Roomans GM (2003). Activation of CFTR by genistein in human airway epithelial cell lines. Biochem Biophys Res Commun 308: 518-522. (Pubitemid 36945523)
3. Baker MJ, Hamilton KL (2004). Genistein stimulates electrogenic Cl-secretion in mouse jejunum. Am J Physiol Cell Physiol 287: C1636-C1645.
4. Banks MR, Farthing MJG (2002). Fluid and electrolyte transport in the small intestine. Curr Opin Gastroenterol 18: 176-181. (Pubitemid 34261249)
5. Barnes S, Petersen TG (1995). Biochemical targets of the isoflavone genistein In tumor cell lines. Proc Soc Exp Biol Med 208: 103-108.
6. Bradbury NA (1999). Intracellular CFTR: localization and function. Physiol Rev 79: S175-S191.
7. - transport in mutations associated with cystic fibrosis. Nature 410: 94-97.
8. Flemström G, Isenberg JI (2001). Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 16: 23-28. (Pubitemid 33574453)
9. Galietta LJ, Moran O (2004). Identification of CFTR activators and inhibitors: chance or design? Curr Opin Pharmacol 4: 497-503.
10. - secretion in the murine trachea and colon. Am J Physiol Cell Physiol 279: C383-C392.
11. Gray MA, Plant S, Argent BE (1993). cAMP-regulated whole cell chloride currents in pancreatic duct cells. Am J Physiol 264: C591-C602. (Pubitemid 23103919)
12. Grubb B, Boucher R (1999). Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiol Rev 79: S193-S214. (Pubitemid 29058915)
13. Guggino WB, Stanton BA (2006). New insights into cystic fibrosis: molecular switches that regulate CFTR. Nature Rev Mol Cell Biol 7: 426-436.
14. - secretion. Am J Physiol 272: G872-G878.
15. Hogan DL, Crombie DL, Isenberg JI, Svendsen P, Schaffalitzky de Muckadell OB, Ainsworth MA (1997b). Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice. Gastroenterology 113: 533-541. (Pubitemid 27351780)
16. - channel by the tyrosine kinase inhibitor genistein. Am J Physiol 268: C886-C893.
17. Illek B, Zhang L, Lewis NC, Moss RB, Dong JY, Fischer H (1999). Defective function of the cystic fibrosis-causing missence mutation G551D is recovered by genistein. Am J Physiol Cell Physiol 277: C833-C839. (Pubitemid 29525922)
18. Leung GPH, Wong PYD (2000). Activation of cystic fibrosis transmembrane conductance regulator in rat epididymal epithelium by genistein. Biol Reprod 62: 143-149.
19. Linsdell P, Tabcharanl JA, Rommens JM, Hou YX, Chang XB, Tsui LC et al (1997). Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions. J Gen Physiol 110: 355-364. (Pubitemid 27431174)
20. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ et al. (2002). Thiazolidinone CFTR inhibitor identified by highthroughput screening blocks cholera toxin-induced intestinal fluid secretion. / Clin Invest 110: 1651-1658. (Pubitemid 35424243)
21. Poulsen JH, Fischer H, Illek B, Machen TE (1994). Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci USA 91: 5340-5344. (Pubitemid 24174322)
22. Quinton PM (1990). Cystic fibrosis: a disease in electrolyte transport. FASEB J 4: 2709-2717. (Pubitemid 20226258)
23. Quinton PM (1999). Physiological basis of cystic fibrosis: a historical perspective. Physiol Rev 79 (Suppl. 1): S3-S22. (Pubitemid 29058907)
24. Quinton PM (2008). Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis. Lancet 372 (9636): 415-417.
25. - conductance.J Pancreas 2 (Suppl. 4): 212-218.
26. Reddy MM, Quinton PM (2003). Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells. Nature 423: 756-760.
27. Riordan JR (2005). Assembly of functional CFTR chloride channels. Annu Rev Physiol 67: 701-718.
28. Riordan JR, Rommens JM, Kerem B-S, Alon N, Rozmahel R, Grzelczak Z et al. (1989). Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073. (Pubitemid 19231814)
29. Schmidt A, Hughes LK, Cal Z, Mendes F, Li H, Sheppard DN et at. (2008). Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator. Br J Pharmacol 153: 1311-1323.
30. - secretion. J Physiol (Lond) 505: 411-423.
31. - selectivity by external Cl. J Biol Chem 279: 21857-21865.
32. Sheppard DN, Welsh MJ (1999). Structure and function of the CFTR chloride channel. Physiol Rev 79: S23-S45. (Pubitemid 29058908)
33. Tuo BG, Isenberg JI (2003). Effect of 5-hydroxytryptamine on duodenal mucosal bicarbonate secretion in mice. Gastroenterology 125: 805-814. (Pubitemid 37070698)
34. - secretion. Gastroenterology 130: 349-358.
35. Tuo BG, Wen GR, Seidler U (2007). Phosphatidylinositol-3 kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 293: G279-G287.
36. Weinreich F, Wood PG, Riordan JR, Naget G (1997). Direction action of genistein on CFTR. Pfluger Archs-Eur J Physiol 434: 484-491.
37. Willumsen NJ, Boucher RC (1992). Intracellular pH and its relationship to regulation of ion transport in normal and cystic fibrosis human nasal eplthelia. J Physiol (Lond) 455: 247-269.