Engineering polymer blend microparticles: An investigation into the influence of polymer blend distribution and interaction

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 1-2, 2011, Pages 30-36

  Alhnan, Mohamed A ^a   Basit, Abdul W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Colonic delivery; Composite microparticles; Electrostatic complex; Enteric polymers; Enteric release; Microspheres; Polymethacrylates; Polymethacrylic acid

Indexed keywords

BLEND MICROPARTICLE; ETHYL CELLULOSE; EUDRAGIT; EUDRAGIT RS; NANOPARTICLE; POLYMER; PREDNISOLONE; UNCLASSIFIED DRUG;

ARTICLE; DISSOLUTION; DRUG RELEASE; EMULSION; EVAPORATION; GASTROINTESTINAL TRACT; GLASS TRANSITION TEMPERATURE; MISCIBILITY; MOLECULAR INTERACTION; PH; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THERMAL ANALYSIS;

ACRYLIC RESINS; CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; DRUG CARRIERS; DRUG COMPOUNDING; GASTROINTESTINAL TRACT; HYDROGEN-ION CONCENTRATION; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PHASE TRANSITION; POLYMERS; POLYMETHACRYLIC ACIDS; PREDNISOLONE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 78650676598     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.10.003     Document Type: Article

References (37)

1. A. Akhgari, G.H. Afrasiabi, F. Sadeghi, and M. Azimaie Statistical optimization of indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug delivery Int. J. Pharm. 305 2005 22 30
2. A. Akhgari, F. Sadeghi, and H.A. Garekani Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets Int. J. Pharm. 320 2006 137 142
3. M.A. Alhnan, D. Cosi, S. Murdan, and A.W. Basit Inhibiting the gastric burst release of drugs from enteric microparticles: the influence of drug molecular mass and solubility J. Pharm. Sci. 99 2010 4576 4583
4. K. Amighi, J. Timmermans, J. Puigdevall, E. Baltes, and A.J. Moes Peroral sustained-release film-coated pellets as a means to overcome physicochemical and biological drug-related problems. I. In vitro development and evaluation Drug Dev. Ind. Pharm. 24 1998 509 515 (Pubitemid 28273117)
5. C. Berkland, K. Kim, and D.W. Pack PLG microsphere size controls drug release rate through several competing factors Pharm. Res. 20 2003 1055 1062
6. S. Chandran, K.S. Sanjay, and L.F. Asghar Microspheres with pH modulated release: design and characterization of formulation variables for colonic delivery J. Microencapsul. 2008 1 11
7. T.Y. Fan, S.L. Wei, W.W. Yan, D.B. Chen, and J. Li An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets J. Control. Release 77 2001 245 251
8. M. Hori, H. Onishi, and Y. Machida Evaluation of Eudragit-coated chitosan microparticles as an oral immune delivery system Int. J. Pharm. 297 2005 223 234
9. V.C. Ibekwe, H.M. Fadda, E.L. McConnell, M.K. Khela, D.F. Evans, and A.W. Basit Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems Pharm. Res. 25 2008 1828 1835
10. R. Kendall, M.A. Alhnan, S. Nilkumhang, S. Murdan, and A.W. Basit Fabrication and in vivo evaluation of highly pH-responsive acrylic microparticles for targeted gastrointestinal delivery Eur. J. Pharm. Sci. 37 2009 284 290
11. M. Kilicarslan, and T. Baykara Effects of the permeability characteristics of different polymethacrylates on the pharmaceutical characteristics of verapamil hyhdrochloride-loaded microspheres J. Microencapsul. 21 2004 175 189
12. Y. Krishnamachari, P. Madan, and S. Lin Development of pH- and time-dependent oral microparticles to optimize budesonide delivery to ileum and colon Int. J. Pharm. 338 2007 238 247
13. A. Lamprecht, U.F. Schafer, and C. Lehr Characterization of microcapsules by confocal laser scanning microscopy: structure, capsule wall composition and encapsulation rate Eur. J. Pharm. Biopharm. 49 2000 1 9
14. A. Lamprecht, U.F. Schafer, and C.M. Lehr Visualization and quantification of polymer distribution in microcapsules by confocal laser scanning microscopy (CLSM) Int. J. Pharm. 196 2000 223 226
15. A. Lamprecht, H. Yamamoto, H. Takeuchi, and Y. Kawashima Microsphere design for the colonic delivery of 5-fluorouracil J. Control. Release 90 2003 313 322
16. A. Lamprecht, H. Yamamoto, H. Takeuchi, and Y. Kawashima Design of pH-sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus Eur. J. Pharm. Biopharm. 58 2004 37 43
17. A. Lamprecht, H. Yamamoto, H. Takeuchi, and Y. Kawashima Observations in simultaneous microencapsulation of 5-fluorouracil and leucovorin for combined pH-dependent release Eur. J. Pharm. Biopharm. 59 2005 367 371
18. A. Lamprecht, H. Yamamoto, N. Ubrich, H. Takeuchi, P. Maincent, and Y. Kawashima FK506 microparticles mitigate experimental colitis with minor renal calcineurin suppression Pharm. Res. 22 2005 193 199
19. F. Lecomte, J. Siepmann, M. Walther, R.J. MacRae, and R. Bodmeier Polymer blends used for the coating of multiparticulates: comparison of aqueous and organic coating techniques Pharm. Res. 21 2004 882 890 (Pubitemid 39011315)
20. K. Lehmman In Wasser dispergierbare, hydrophile Acrylharze mit abgesufter Permeabilitat fur diffusionsgesteuerte Wirkstoffabgabe aus Arzneifformen Acta Pharm. Technol. 32 1986 146 152
21. M.L. Lorenzo-Lamosa, M. Cuna, J.L. Vila-Jato, D. Torres, and M.J. Alonso Development of a microencapsulated form of cefuroxime axetil using pH-sensitive acrylic polymers J. Microencapsul. 14 1997 607 616
22. M.L. Lorenzo-Lamosa, C. Remunan-Lopez, J.L. Vila-Jato, and M.J. Alonso Design of microencapsulated chitosan microspheres for colonic drug delivery J. Control. Release 52 1998 109 118
23. E. McConnell, F. Liu, and A.W. Basit Colonic treatments and targets: issues and opportunities J. Drug Target. 17 2009 335 363
24. E.L. McConnell, M.D. Short, and A.W. Basit An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man J. Control. Release 130 2008 154 160
25. Y. Meissner, N. Ubrich, G.F. El, P. Maincent, and A. Lamprecht Low molecular weight heparin loaded pH-sensitive microparticles Int. J. Pharm. 335 2007 147 153
26. A.R. Menjoge, and M.G. Kulkarni Mechanistic investigations of phase behavior in Eudragit E blends Int. J. Pharm. 343 2007 106 121
27. D.L. Munday Film coated pellets containing verapamil hydrochloride: enhanced dissolution into neutral medium Drug Dev. Ind. Pharm. 29 2003 575 583
28. S. Nilkumhang, M.A. Alhnan, E.L. McConnell, and A.W. Basit Drug distribution in enteric microparticles Int. J. Pharm. 379 2009 1 8
29. S. Nilkumhang, and A.W. Basit The robustness and flexibility of an emulsion solvent evaporation method to prepare pH-responsive microparticles Int. J. Pharm. 377 2009 135 141
30. D.M. Omari, A. Sallam, A. bd-Elbary, and M. El-Samaligy Lactic acid-induced modifications in films of Eudragit RL and RS aqueous dispersions Int. J. Pharm. 274 2004 85 96
31. A. Paharia, A.K. Yadav, G. Rai, S.K. Jain, S.S. Pancholi, and G.P. Agrawal Eudragit-coated pectin microspheres of 5-fluorouracil for colon targeting AAPS PharmSciTech 8 2007 12
32. R.P. Raffin, D.S. Jornada, M.I. Re, A.R. Pohlmann, and S.S. Guterres Sodium pantoprazole-loaded enteric microparticles prepared by spray drying: effect of the scale of production and process validation Int. J. Pharm. 324 2006 10 18
33. Z. Rahman, K. Kohli, R.K. Khar, M. Ali, N.A. Charoo, and A.A. Shamsher Characterization of 5-fluorouracil microspheres for colonic delivery AAPS PharmSciTech 7 2006 E47
34. F. Siepmann, J. Siepmann, M. Walther, R.J. MacRae, and R. Bodmeier Blends of aqueous polymer dispersions used for pellet coating: importance of the particle size J. Control. Release 105 2005 226 239
35. J. Varez-Fuentes, M. Fernandez-Arevalo, M.L. Gonzalez-Rodriguez, M. Cirri, and P. Mura Development of enteric-coated timed-release matrix tablets for colon targeting J. Drug Target. 12 2004 607 612
36. N. Yuksel, E. Dinc, F. Onur, and T. Baykara Influence of swelling degree on release of nicardipine hydrochloride from acrylic microspheres prepared by solvent evaporation method Pharm. Dev. Technol. 3 1998 115 121
37. W. Zheng, and J.W. McGinity Influence of Eudragit NE 30 D blended with Eudragit L 30 D-55 on the release of phenylpropanolamine hydrochloride from coated pellets Drug Dev. Ind. Pharm. 29 2003 357 366