Fabrication and in vivo evaluation of highly pH-responsive acrylic microparticles for targeted gastrointestinal delivery

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 3-4, 2009, Pages 284-290

  Kendall, Richard A ^a   Alhnan, Mohamed A ^a   Nilkumhang, Suchada ^a   Murdan, Sudaxshina ^a   Basit, Abdul W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Arlacel 83; Colonic delivery; Delayed release; Emulsion solvent evaporation; Enteric polymers; Eudragit; Microspheres; Small intestine

Indexed keywords

EUDRAGIT; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROL GROUP; CONTROLLED STUDY; DELAYED DRUG RELEASE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; IN VIVO STUDY; INTESTINE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PH; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACRYLATES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; GASTROINTESTINAL TRACT; HYDROGEN-ION CONCENTRATION; MALE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; PREDNISOLONE; RATS; RATS, WISTAR; SOLUBILITY; SUSPENSIONS; VISCOSITY; X-RAY DIFFRACTION;

EID: 67349281689     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.02.015     Document Type: Article

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