Statistical optimization of indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug delivery

International Journal of Pharmaceutics

Volumn 305, Issue 1-2, 2005, Pages 22-30

  Akhgari, A ^a,c   Garekani, H Afrasiabi ^a   Sadeghi, F ^a   Azimaie, M ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c Culture and Research   (Iran)

Author keywords

Colonic delivery; Eudragit; Factorial design; Indomethacin; Statistical optimization

Indexed keywords

EUDRAGIT; INDOMETACIN; POLYMETHACRYLIC ACID;

ACIDITY; ARTICLE; COLON; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FLUIDIZED BED; ILEUM; MATERIAL COATING; PH; PRIORITY JOURNAL; SMALL INTESTINE; STATISTICAL ANALYSIS; STOMACH PH;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; COLON; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; GASTROINTESTINAL TRANSIT; HYDROGEN-ION CONCENTRATION; INDOMETHACIN; INTESTINAL ABSORPTION; MODELS, STATISTICAL; POLYMETHACRYLIC ACIDS; SOLUBILITY;

EID: 27644477124     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.08.025     Document Type: Article

References (15)

1. A. Bodea, and S.E. Leucuta Optimization of propranolol hydrochloride sustained release pellets using a factorial design Int. J. Pharm. 154 1997 49 57
2. M.K. Chourasia, and S.K. Jain Pharmaceutical approaches to colon targeted drug delivery systems J. Pharm. Pharm. Sci. 6 2003 33 66
3. D.F. Evans, G. Pye, R. Bramley, A.G. Clark, T.J. Dyson, and J.D. Hardcastle Measurement of gastrointestinal pH profiles in normal ambulant human subjects Gut 29 1988 1035 1041
4. S.M. Fischer Prostaglandins and cancer Front. Biosci. 2 1997 d482 d500
5. O. Gallo, A. Franchi, L. Magnelli, I. Sardi, A. Vannacci, V. Boddi, V. Chiarugi, and E. Masini Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis Neoplasia 3 2001 53 61
6. M.C. Gohel, and A.F. Amin Formulation optimization of controlled release diclofenac sodium microspheres using factorial design J. Control. Release 51 1998 115 122
7. V.K. Gupta, T.E. Beckert, and J.C. Price A novel pH- and time-based multi-unit potential colonic drug delivery system. I. Development Int. J. Pharm. 213 2001 83 91
8. C.C. Kao, S.C. Chen, and M.T. Sheu Lag time method to delay drug release to various sites in the gastrointestinal tract J. Control. Release 44 1997 263 270
9. M.Z.I. Khan, Z. Prebeg, and N. Kurjakovic A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation of drug release using Eudragit L100-55 and Eudragit S100 combinations J. Control. Release 58 1999 215 222
10. A. Kramar, S. Turk, and F. Vrecer Statistical optimisation of diclofenac sustained release pellets coated with polymethacrylic films Int. J. Pharm. 256 2003 43 52
11. C.S. Leopold Coated dosage forms for colon-specific drug delivery PSTT 2 1999 197 204
12. M. Marvola, P. Nykanen, S. Rautio, N. Isonen, and A.M. Autere Enteric polymers as binders and coating materials in multiple-unit site-specific drug delivery systems Eur. J. Pharm. Sci. 7 1999 259 267
13. M. Rodriguez, J.L. Vila-Jato, and D. Torres Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region J. Control. Release 55 1998 67 77
14. T. Sam, and M.H. Rubinstein Oral sustained release drug delivery: pellets or tablets Pharm. Int. 6 1985 265 266
15. P.J. Watts, and L. Illum Colonic drug delivery Drug Dev. Ind. Pharm. 23 1997 893 913